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Latest Research on Drug Carrier
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Latest Research on Drug Carrier

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 5190

Special Issue Editors

Dr. Chunsheng Xiao

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Guest Editor
Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
Interests: polymeric carrier; drug delivery; protein delivery; polymer therapeutics; controlled drug release
Dr. Peng Zhang

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Assistant Guest Editor
Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
Interests: polymeric carrier; drug delivery; protein delivery; gene delivery; controlled drug release
Dr. Yu Zhang

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Assistant Guest Editor
Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
Interests: polymeric carrier; drug delivery; protein delivery; polymer therapeutics; controlled drug release
Dr. Pan He

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Assistant Guest Editor
School of Materials Science and Engineering, Changchun University of Science and Technology, Changchun, China
Interests: polymeric carrier; drug delivery; protein delivery; polymer therapeutics; controlled drug release
Dr. Mingqian Li

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Assistant Guest Editor
Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, China
Interests: Immunotherapy; transplantation immunology; cell therapy; gene therapy; translational medicine

Special Issue Information

Dear Colleagues,

Drug carriers including polymeric nanocarriers, lipid-based nanocarriers, inorganic nanocarriers and composite nanocarriers have been widely used to improve the effectiveness, selectivity and safety of various drugs. Benefiting from the great advances of biology, medicine, chemistry, materials science and nanotechnology, a growing number of drug carriers have been translated from bench to bedside. However, improvements in biodegradability, biocompatibility, immunogenicity, targeting ability, stimuli-responsiveness, and delivery efficiency of drug carriers remain needed to further facilitate the translation of nanomedicines and meet the new requirements of clinical applications.

This Special Issue aims to cover the recent outstanding advances in design and preparation of novel drug carriers with the ideal physicochemical and biological properties to improve the therapeutic outcomes of various therapeutic agents including chemotherapeutics, immunostimulatory molecules, nucleic acids, antibodies, tumor antigens and therapeutic proteins. It is our pleasure to invite you to contribute a manuscript to this Special Issue. Research articles, reviews, and short communications are all welcome.

Dr. Chunsheng Xiao
Guest Editor

Dr. Peng Zhang
Dr. Yu Zhang
Dr. Pan He
Dr. Mingqian Li
Assistant Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymeric nanocarriers
  • lipid-based nanocarriers
  • inorganic nanocarriers
  • composite nanocarriers
  • drug delivery
  • gene delivery
  • protein delivery
  • immunotherapy

Published Papers (1 paper)

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Research

26 pages, 54260 KiB  
Article
Optimization of the Conditions of Solid Lipid Nanoparticles (SLN) Synthesis
by Ewelina Musielak, Agnieszka Feliczak-Guzik and Izabela Nowak
Molecules 2022, 27(7), 2202; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27072202 - 28 Mar 2022
Cited by 24 | Viewed by 4781
Abstract
Solid lipid nanoparticles (SLNs) have been synthesized as potential drug delivery systems. They are classified as solid lipid nanocarriers that can successfully carry both hydrophilic and hydrophobic drugs. SLNs are based on a biocompatible lipid matrix that is enzymatically degraded into natural components [...] Read more.
Solid lipid nanoparticles (SLNs) have been synthesized as potential drug delivery systems. They are classified as solid lipid nanocarriers that can successfully carry both hydrophilic and hydrophobic drugs. SLNs are based on a biocompatible lipid matrix that is enzymatically degraded into natural components found in the human body. Solid lipid nanoparticles are suitable for the incorporation of hydrophobic active ingredients such as curcumin. The study included the optimization of lipid nanoparticle composition, incorporation of the active compound (curcumin), a stability evaluation of the obtained nanocarriers and characterization of their lipid matrix. Through process optimization, a dispersion of solid lipid nanoparticles (solid lipid:surfactant—2:1.25 weight ratio) predisposed to the incorporation of curcumin was developed. The encapsulation efficiency of the active ingredient was determined to be 99.80%. In stability studies, it was found that the most suitable conditions for conducting high-pressure homogenization are 300 bar pressure, three cycles and a closed-loop system. This yields the required values of the physicochemical parameters (a particle size within a 200–450 nm range; a polydispersity index of <30%; and a zeta potential of about |±30 mV|). In this work, closed-loop high-pressure homogenization was used for the first time and compared to the currently preferred open-loop method. Full article
(This article belongs to the Special Issue Latest Research on Drug Carrier)
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