Special Issue "Synthesis and Bioanalysis of Steroids and Steroid Biosynthesis Inhibitors"
Deadline for manuscript submissions: 15 June 2021.
Interests: medicinal chemistry; steroids; natural products; antifungals; epigenetic targets; cation channels
Steroids are a versatile and structurally diverse class of molecules widespread in nature. They are known as cell-building material and as signaling molecules. In recent years, our understanding of the role of steroids and steroid biosynthesis enzymes has significantly evolved. Recent studies have shown that steroids have diverse and hitherto unknown physiological functions. They are involved in the pathomechanisms of diseases or play a role in the inflammatory process in humans. Furthermore, the main target of antifungal therapy is the ergosterol biosynthesis or directly ergosterol, and related mechanisms have been found in other pathogenic organisms such as protozoa. Thus, the function of the steroids, the enzymes involved in their biosynthesis, as well as inhibitors of these enzymes as drug candidates are of great interest. Hence, the demand for authentic steroid standards for their use in bioassays and for analytical approaches cannot be met by simply extraction of steroids from natural sources. Consequently, new methods for isolation and total and partial synthesis of steroids are highly demanded.
This Special Issue is devoted to recent developments in biochemistry, chemistry, and qualitative and quantitative analysis of steroids from different origins to get a better insight into the molecular mechanisms of physiological functions and metabolism of steroids.
This also includes the development of steroid biosynthesis inhibitors as molecular tools for studying pathomechanisms, as novel drugs fighting against upcoming antifungal drug resistance, or as first-in-class drug candidates targeting distinct enzymes in cholesterol biosynthesis, whose enormous therapeutic potential has been highlighted in the past few years.
Prof. Dr. Franz Bracher
Dr. Christoph Müller
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Enzyme inhibitors (chemistry and pharmacology)
- Steroid analysis in diverse samples (tissues, plant material, screening systems)
- Biological activities and metabolism
- Steroid biosynthesis
- Synthesis of steroids and analogues
- Steroid isolation from diverse sources (mammals, plants, microorganisms)
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Unearthing the sterolome yields suicide antimetabolites of therapeutic significance
Authors: W. David Nes
Affiliation: Texas Tech University, USA
Abstract: Not Ready