Special Issue "Alkaloids: Novel Therapeutic Perspectives"
Deadline for manuscript submissions: closed (31 October 2014).
Interests: metabolite profiling of natural matrices; evaluation of bioactive agents from natural sources; polyphenols
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Finding novel bioactive compounds of natural origin has been a major concern for pharmaceuticals research. Among those natural products, alkaloids area among the oldest drugs in medicine and are promising, novel drug candidates. Alkaloids are characterized by the presence of a basic nitrogen (usually in a heterocycle); they exhibit highly complex structures that are believed to function as herbivorism deterrents in plants. Hence, they show strong physiological activities in animals, which may translate into important therapeutic actions in humans, under adequate dosages. In recent years, the number of new alkaloids isolated, identified, and studied for their medicinal potential has increased. These alkaloids largely originate from unexpected organisms, such as marine sponges, algae, etc. Moreover, the characterization of many novel therapy targets urges the reappraisal of old alkaloids. This Special Issue is devoted to the recent knowledge concerning the potential of alkaloids as therapeutic options for human diseases, their targets, and mechanisms of action.
Prof. Dr. Patricia Valentao
Prof. Dr. Mariana Sottomayor
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access semimonthly journal published by MDPI.
- Pyridine group: piperine, coniine, trigonelline, arecaidine, guvacine, pilocarpine, cytisine, nicotine, sparteine, pelletierine.
- Pyrrolidine group: hygrine, cuscohygrine, nicotine.
- Tropane group: atropine, cocaine, ecgonine, scopolamine, catuabine.
- Quinoline group: quinine, quinidine, dihydroquinine, dihydroquinidine, strychnine, brucine, veratrine, cevadine.
- Isoquinoline group: the opium alkaloids (morphine, codeine, thebaine, isopapa-dimethoxy-aniline, papaverine, narcotine, sanguinarine, narceine, hydrastine, berberine).
- Phenethylamine group: mescaline, ephedrine, dopamine, amphetamine
- Indole group: tryptamines (DMT, N-methyltryptamine, psilocybin, serotonin), ergolines: the ergot alkaloids (ergine, ergotamine, lysergic acid, etc.), beta-carbolines (harmine, harmaline, yohimbine, reserpine, emetine), rauwolfia alkaloids (reserpine).
- Purine group: xanthines (caffeine, theobromine, theophylline).
- Terpenoid group: aconite alkaloids (aconitine).
- Steroids: solanine, samandaris, i.e., quaternary ammonium compounds (muscarine, choline, neurine).
- organic chemistry, natural product chemistry, medicinal chemistry, analytical chemistry, etc.