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Antimicrobial Peptides as Natural Substances for Food and Biomedical Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 2834

Special Issue Editor


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Guest Editor
Department of Food Science & Center of Nanoscience and Nanotechnology, Universidade Federal do Rio Grande do Sul, Porto Alegre 91501-970, Brazil
Interests: antimicrobial peptides; natural compounds; bioactive peptides; antitumoral peptides; food safety; medical microbiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The term “antimicrobial peptides” can be applied to define a diverse class of naturally occurring molecules that are virtually produced by all living organisms. Some antimicrobial peptides can present a broad spectrum of activity and circumvent bacterial drug resistance. Microorganisms often produce antimicrobial peptides to protect their environmental niche, while insects and plants use antimicrobial peptides as defense against potential pathogenic microorganisms. In higher eukaryotes, antimicrobial peptides are also part of the innate immune response, called host defense peptides. Due to their appeal as natural substances, there is a growing interest in research on and applications of antimicrobial peptides in the food, pharmaceutical, and biomedical fields. Some antimicrobial peptides have been successfully employed in the food industry, and many others have been investigated as food biopreservatives. Although there are no approved clinical uses for natural antimicrobial peptides, increasing evidence of their effectiveness in vivo points to their huge potential as medicines to combat infections. The main objectives of the Special Issue on “Antimicrobial Peptides as Natural Substances for Food and Biomedical Applications” is to provide an open forum for researchers to share their investigation and findings in this exciting field and, thanks to the open access platform, increase their visibility and chances to interact with industries and production systems. Contributions to this issue, both in the form of original research and review articles, may cover all aspects of antimicrobial peptides. Multidisciplinary studies offering innovative methodologies or perceptions are particularly welcome. 

Prof. Dr. Adriano Brandelli
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • Antimicrobial peptides
  • Natural antimicrobials
  • Food microbiology
  • Bacteriocins
  • Infectious diseases
  • Clinically relevant microorganisms
  • Antimicrobial resistance
  • Defensins

Published Papers (1 paper)

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Review

17 pages, 1800 KiB  
Review
Lights and Shadows on the Therapeutic Use of Antimicrobial Peptides
by Denise Bellotti and Maurizio Remelli
Molecules 2022, 27(14), 4584; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27144584 - 18 Jul 2022
Cited by 21 | Viewed by 2443
Abstract
The emergence of antimicrobial-resistant infections is still a major concern for public health worldwide. The number of pathogenic microorganisms capable of resisting common therapeutic treatments are constantly increasing, highlighting the need of innovative and more effective drugs. This phenomenon is strictly connected to [...] Read more.
The emergence of antimicrobial-resistant infections is still a major concern for public health worldwide. The number of pathogenic microorganisms capable of resisting common therapeutic treatments are constantly increasing, highlighting the need of innovative and more effective drugs. This phenomenon is strictly connected to the rapid metabolism of microorganisms: due to the huge number of mutations that can occur in a relatively short time, a colony can “adapt” to the pharmacological treatment with the evolution of new resistant species. However, the shortage of available antimicrobial drugs in clinical use is also caused by the high costs involved in developing and marketing new drugs without an adequate guarantee of an economic return; therefore, the pharmaceutical companies have reduced their investments in this area. The use of antimicrobial peptides (AMPs) represents a promising strategy for the design of new therapeutic agents. AMPs act as immune defense mediators of the host organism and show a poor ability to induce antimicrobial resistance, coupled with other advantages such as a broad spectrum of activity, not excessive synthetic costs and low toxicity of both the peptide itself and its own metabolites. It is also important to underline that many antimicrobial peptides, due to their inclination to attack cell membranes, have additional biological activities, such as, for example, as anti-cancer drugs. Unfortunately, they usually undergo rapid degradation by proteolytic enzymes and are characterized by poor bioavailability, preventing their extensive clinical use and landing on the pharmaceutical market. This review is focused on the strength and weak points of antimicrobial peptides as therapeutic agents. We give an overview on the AMPs already employed in clinical practice, which are examples of successful strategies aimed at overcoming the main drawbacks of peptide-based drugs. The review deepens the most promising strategies to design modified antimicrobial peptides with higher proteolytic stability with the purpose of giving a comprehensive summary of the commonly employed approaches to evaluate and optimize the peptide potentialities. Full article
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