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Synthesis of Benzo-Fused Heterocycles

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 1920

Special Issue Editor


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Guest Editor
Department of Chemistry and Industrial Chemistry, Università di Genova, Via Dodecaneso 31, I-16146 Genova, Italy
Interests: benzannulations; heterocycles; fused heteroaromatics; cyclizations

Special Issue Information

Dear Colleagues,

Heterocyclic compounds represent an ever-expanding research field, not only for their chemical aspects, but also for the very broad applicative possibilities, mainly in pharmaceutical, agrochemical, optoelectronic areas.

Among the plethora of more or less complex systems that are recognizable within the structure of natural and synthetic compounds showing biological activities (antimalarial, antifungal, antibacterial, antiasthmatic, antihypertensive, anti-inflammatory, etc.), indoles, quinolines, coumarins, and benzodiazepines are particularly frequent, so are to be considered as privileged structures.

This Special Issue intends to focus on synthetic approaches to benzo-fused heterocycles, classically built starting from benzene derivatives, or more recently by benzannulation reactions, through ionic or pericyclic processes, possibly coadjuvated by metals, light, or organocatalysts, to ameliorate efficiency and selectivity.

Prof. Dr. Cinzia Tavani
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heterocyclic compounds
  • reaction mechanism
  • annulation
  • pericyclic reactions
  • organic synthesis
  • green chemistry
  • natural products
  • pharmaceuticals
  • bioactive compounds

Published Papers (1 paper)

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Research

11 pages, 3743 KiB  
Article
Aerial Oxygen-Driven Selenocyclization of O-Vinylanilides Mediated by Coupled Fe3+/Fe2+ and I2/I Redox Cycles
by Hao-Yuan Zhang, Tong-Tong Zeng, Zhen-Biao Xie, Ying-Ying Dong, Cha Ma, Shan-Shan Gong and Qi Sun
Molecules 2022, 27(21), 7386; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27217386 - 31 Oct 2022
Cited by 2 | Viewed by 1275
Abstract
In the past decade, selenocyclization has been extensively exploited for the preparation of a wide range of selenylated heterocycles with versatile activities. Previously, selenium electrophile-based and FeCl3-promoted methods were employed for the synthesis of selenylated benzoxazines. However, these methods are limited [...] Read more.
In the past decade, selenocyclization has been extensively exploited for the preparation of a wide range of selenylated heterocycles with versatile activities. Previously, selenium electrophile-based and FeCl3-promoted methods were employed for the synthesis of selenylated benzoxazines. However, these methods are limited by starting material availability and low atomic economy, respectively. Inspired by the recent catalytic selenocyclization approaches based on distinctive pathways, we rationally constructed an efficient and greener double-redox catalytic system for the access to diverse selenylated benzoxazines. The coupling of I2/I and Fe3+/Fe2+ catalytic redox cycles enables aerial O2 to act as the driving force to promote the selenocyclization. Control and test redox experiments confirmed the roles of each component in the catalytic system, and a PhSeI-based pathway is proposed for the selenocyclization process. Full article
(This article belongs to the Special Issue Synthesis of Benzo-Fused Heterocycles)
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