Synthesis of Biologically Active Biaryls and Heterobiaryls
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".
Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 374
Special Issue Editor
Interests: multicomponent reactions for low environmental impact synthesis; organoselenium chemistry; stereoselective synthesis of heterocyclic compounds; Diels-Alder reactions for the synthesis of (hetero)biaryls and stilbenes; green synthetic methodology in organic chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Biaryls and heterobiaryls are molecular systems recognized as “privileged structures”, i.e., molecules with a framework that makes ligands suitable for different biological receptors. These structural reasons are present in more than 75% of the drugs on the market today or in phase III trials and used in different therapeutic areas as hypocholesterolemic, antitumoral, antihypertensive, anti-inflammatory, analgesic, antidiabetic, antifungal, antimicrobial, and antiviral agents. Moreover, different biaryls and heterobiaryls are a key feature in natural products such as Vancomycin, Pterocaryanin C, Dictyobiphenyls, Gossypol, Honokiol, Ancistrobreveines A-D, Streptonigrin, Alocasin A, and Vingramine. Given the importance of these scaffolds, several synthetic approaches have been developed so far, mainly involving transition metal-catalyzed cross-coupling and C–H arylation reactions. However, metal-free approaches to biaryls and heterobiaryls such as arylation reaction involving radical intermediates, oxidative cross-coupling reaction, photoarylation processes, benzannulation and Diels–Alder reactions have also been reported.
Communications, full papers, and reviews on this topic are really appreciated and welcome.
Prof. Dr. Andrea Temperini
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Biaryls
- Heterobiaryls
- Natural products
- Pharmaceutical
- Bioactive compounds
- Organic synthesis
- C–C coupling
- Cycloaddition
- Annulation
