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Special Issue "Bioactive Compounds for Cosmeceuticals against Skin Diseases"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Dr. María De La Luz Cádiz-Gurrea
E-Mail Website
Guest Editor
Department of Analytical Chemistry of the Univeristy of Granada (Spain) and GRAQ, LAVQ/REQUIMTE, ISEP, Porto (Portugal)
Interests: bioactive compounds; bioactive ingredients; analytical techniques; mass spectrometry; nutraceuticals; cosmeceuticals; metabolomic studies; byproduct revalorization; oxidative stress; inflammation; aging; skin diseases; rare diseases
Prof. Dr. Antonio Segura-Carretero
E-Mail Website
Guest Editor
Department of Analytical Chemistry of the Univeristy of Granada and Center of Research and Development of Functional Foods (CIDAF), Granada, Spain.
Interests: functional food; bioactive compounds; analytical techniques; mass spectrometry; nutraceuticals; metabolomic studies; by-products revalorization.
Special Issues and Collections in MDPI journals
Prof. Dr. David Arráez-Román
E-Mail Website1 Website2
Guest Editor
1. Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avda Fuentenueva s/n, 18071 Granada, Spain
2. Research and Development of Functional Food Centre (CIDAF), Health Science Technological Park (PTS) Granada, Avda. del Conocimiento s/n, EdificioBioregión, 18007 Granada, Spain
Interests: bioactive phenolic compounds; metabolomics; analytical techniques; extraction processes; plant and food analysis; bioavailability
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Nowadays, a hot topic in the cosmetic industry is ‘cosmeceuticals’. This term represents the fastest growing area of natural personal care which intends to enhance skin health through ingredients that provide additional health properties or benefits. In fact, they can be considered as cosmetics but contain bioactive compounds that exert different effects on skin function. Generally, the bioactive compounds which are used in this field, such as vitamins or phenolic compounds, are obtained from natural sources, and although the effects of bioactive compounds in individual cosmeceuticals may be small, their magnitude can be increased, synergistically, by combining materials, especially those with different mechanisms of action. For these reasons, the main aim of the Special Issue on “Bioactive Compounds for Cosmeceuticals against Skin Diseases” is to be an open forum where researchers may share their investigations and findings in this promising field and, thanks to the open access platform, increase their visibility and the chances to interact with industries and their production systems. Contributions to this issue, both in the form of original research or review articles, may cover all aspects of bioactive compounds for cosmeceuticals; studies with multidisciplinary input, offering new methodologies or targets, are particularly welcome.

Dr. María De La Luz Cádiz-Gurrea
Prof. Dr. Antonio Segura-Carretero
Prof. Dr. David Arráez-Román
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cosmeceuticals
  • Bioactive compounds
  • Skin diseases
  • Natural sources
  • Prevention
  • Skin health

Published Papers (3 papers)

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Research

Article
Santamarine Shows Anti-Photoaging Properties via Inhibition of MAPK/AP-1 and Stimulation of TGF-β/Smad Signaling in UVA-Irradiated HDFs
Molecules 2021, 26(12), 3585; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26123585 - 11 Jun 2021
Viewed by 277
Abstract
Chronic UVA exposure results in elevated reactive oxygen species in skin which leads to photoaging characterized as upregulated matrix metalloproteinase (MMP)-1 and loss of collagen. Therefore, natural antioxidants are hailed as promising agents to be utilized against photoaging. In the current study, reynosin [...] Read more.
Chronic UVA exposure results in elevated reactive oxygen species in skin which leads to photoaging characterized as upregulated matrix metalloproteinase (MMP)-1 and loss of collagen. Therefore, natural antioxidants are hailed as promising agents to be utilized against photoaging. In the current study, reynosin and santamarine, two known sesquiterpene lactones isolated from Artemisia scoparia, were analyzed for their anti-photoaging properties in UVA-irradiated human dermal fibroblasts (HDFs). Results showed that UVA irradiation (8 J/cm2) upregulated the MMP-1 secretion and expression, and suppressed collagen production, which were significantly reverted by santamarine treatment (10 µM). Although both reynosin and santamarine exhibited ROS scavenging abilities, reynosin failed to significantly diminish UVA-stimulated MMP-1 release. UVA-irradiated HDFs showed increased collagen production when treated with santamarine. As a mechanism to suppress MMP-1, santamarine significantly suppressed the UVA-induced phosphorylation of p38 and JNK and nuclear translocation of p-c-Fos and p-c-Jun. Santamarine promoted collagen I production via relieving the UVA-induced suppression on TGF-β and its downstream activator Smad2/3 complex. Antioxidant properties of santamarine were also shown to arise from stimulating Nrf2-dependent expression of antioxidant enzymes SOD-1 and HO-1 in UVA-irradiated HDFs. In conclusion, santamarine was found to be a promising natural antioxidant with anti-photoaging properties against UVA-induced damages in HDFs. Full article
(This article belongs to the Special Issue Bioactive Compounds for Cosmeceuticals against Skin Diseases)
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Article
Ribes nigrum Leaf Extract Preferentially Inhibits IFN-γ-Mediated Inflammation in HaCaT Keratinocytes
Molecules 2021, 26(10), 3044; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26103044 - 20 May 2021
Viewed by 425
Abstract
Ribes nigrum L. (blackcurrant) leaf extracts, due to high levels of flavonols and anthocyanins, have been shown to exhibit beneficial effects in inflammatory diseases. However, whereas their traditional use has been investigated and validated in several models of inflammation and oxidative stress, the [...] Read more.
Ribes nigrum L. (blackcurrant) leaf extracts, due to high levels of flavonols and anthocyanins, have been shown to exhibit beneficial effects in inflammatory diseases. However, whereas their traditional use has been investigated and validated in several models of inflammation and oxidative stress, the possible impact on skin disorders is still largely unknown. The purpose of this work was to elucidate the effects of R. nigrum leaf extract (RNLE) on keratinocyte-derived inflammatory mediators, elicited by a Th1 or Th2 cytokine milieu. HaCaT cells were challenged with TNF-α, either alone or in combination with the costimulatory cytokines IFN-γ or IL-4, and the release of proinflammatory cytokines and mediators (IL-8, IL-6, s-ICAM-1, and TSLP) was evaluated. The results showed that RNLE preferentially interferes with IFN-γ signaling, demonstrating only negligible activity on TNF-α or IL-4. This effect was attributed to flavonols, which might also account for the ability of RNLE to impair TNF-α/IL-4-induced TSLP release in a cAMP-independent manner. These results suggest that RNLE could have an antiallergic effect mediated in keratinocytes via mechanisms beyond histamine involvement. In conclusion, the discovery of RNLE preferential activity against IFN-γ-mediated inflammation suggests potential selectivity against Th1 type response and the possible use in Th1 inflammatory diseases. Full article
(This article belongs to the Special Issue Bioactive Compounds for Cosmeceuticals against Skin Diseases)
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Article
Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure
Molecules 2021, 26(4), 1063; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26041063 - 18 Feb 2021
Viewed by 594
Abstract
The skin is constantly exposed to external and internal factors that disturb its function. In this work, two nanosystems-levan nanoparticles and a surfactin-stabilized nanoemulsion were preserved (tested for microbial growth) and characterized (size, polydispersity, Zeta potential, and stability). The nanosystems were introduced in [...] Read more.
The skin is constantly exposed to external and internal factors that disturb its function. In this work, two nanosystems-levan nanoparticles and a surfactin-stabilized nanoemulsion were preserved (tested for microbial growth) and characterized (size, polydispersity, Zeta potential, and stability). The nanosystems were introduced in the model formulations-cream, tonic, and gel, and confirmed by TEM. The analysis showed that nanoemulsion has a spherical morphology and size 220–300 nm, while levan nanoparticles had irregular shapes independently of the use of matrix and with particle size (130–260 nm). Additionally, we examined the antiradical effect of levan nanoparticles and nanoemulsion in the prototype of formulations by scavenging DPPH (2,2-diphenyl-1-picrylhydrazyl; EPR spectroscopy). The model cream with both nanosystems and the whole range of products with nanosystems were evaluated in vivo for hydration, elasticity, smoothness, wrinkles and vascular lesions, discoloration, respectively. The cream improved skin condition in all tested parameters in at least 50% of volunteers. The use of more comprehensive care, additionally consisting of a tonic and gel, reduced the previously existing skin discoloration to 10.42 ± 0.58%. The presented prototype formulations are promising in improving skin conditions. Full article
(This article belongs to the Special Issue Bioactive Compounds for Cosmeceuticals against Skin Diseases)
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