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Molecules
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Biomaterials in China
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Biomaterials in China

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Materials Chemistry".

Deadline for manuscript submissions: closed (15 August 2021) | Viewed by 9592

Special Issue Editors

Dr. Mingqiang Li

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Guest Editor
Professor, Laboratory of Biomaterials and Translational Medicine, Sun Yat-sen University, Guangzhou 510630, China
Interests: biomaterials; controlled-release; microphysiological system; microfluidics
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Jianxun Ding

grade E-Mail Website
Guest Editor
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China
Interests: polymer chemistry; self-assembly; nanoparticle; hydrogel; scaffold; biomaterial; controlled drug delivery; immunotherapy; regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Yunlu Dai

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Guest Editor
Faculty of Health Sciences, University of Macau, Macao 999078, China
Interests: nanomaterials for gene and drug delivery, immunotherapy and biological imaging
Dr. Hon Fai Chan

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Guest Editor
Institute for Tissue Engineering and Regenerative Medicine, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
Interests: tissue engineering; stem cells; biomaterials; microfluidics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomaterials are defined as materials that are engineered as an alone form or a complex system for diagnostic or therapeutic purpose by regulating the interactions with components of living systems. The research goal of biomaterials is aimed at providing a diagnostic or therapeutic modality for clinical practice. Their applications include disease diagnosis and therapy, gene vector design, implantable devices, studying the biology of the host response, immunology and toxicology, nanoscale self-assemblies, and tissue engineering.

The biomaterial scientists in China have been spearheading efforts at the forefront of biomaterials, emphasizing therapies of medical technology and regenerative medicine in the clinical disciplines, as well as diagnostic systems that reply on innovative contrast and sensing agents. Motivated by the observation of increasing interest and emerging innovative research output from Chinese laboratories, this Special Issue aims at showcasing the latest advances in this highly interdisciplinary field. This Special Issue of Molecules aims to collect and disseminate state-of-the-art articles and advancements from the biomaterial community in China. Original research papers and comprehensive review articles are welcome.

Prof. Dr. Mingqiang Li
Prof. Dr. Jianxun Ding
Prof. Dr. Yunlu Dai
Prof. Dr. Hon Fai Chan

Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterial synthesis, processing, and characterization
  • advanced bioresponsive biomaterials
  • biomaterials for disease diagnostics
  • biomaterials for drug, gene, and protein delivery
  • biomaterials for tissue engineering
  • biomaterials for implantable device
  • clinical translation of biomaterials

Published Papers (3 papers)

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Research

21 pages, 5121 KiB  
Article
Impact of Different Biochars on Microbial Community Structure in the Rhizospheric Soil of Rice Grown in Albic Soil
by Dawei Yin, Hongyu Li, Haize Wang, Xiaohong Guo, Zhihui Wang, Yandong Lv, Guohua Ding, Liang Jin and Yu Lan
Molecules 2021, 26(16), 4783; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26164783 - 07 Aug 2021
Cited by 26 | Viewed by 2448
Abstract
The purpose of this study was to clarify the effects of biochar on the diversity of bacteria and fungi in the rice root zone and to reveal the changes in soil microbial community structure in the root zone after biochar application to provide [...] Read more.
The purpose of this study was to clarify the effects of biochar on the diversity of bacteria and fungi in the rice root zone and to reveal the changes in soil microbial community structure in the root zone after biochar application to provide a scientific basis for the improvement of albic soil. Rice and corn stalk biochar were mixed with albic soil in a pot experiment. Soil samples were collected at the rice maturity stage, soil nutrients were determined, and genomic DNA was extracted. The library was established using polymerase chain reaction (PCR) amplification. The abundance, diversity index, and community structure of the soil bacterial 16SrRNA gene V3 + V4 region and the fungal internal transcribed spacer-1 (ITS1) region were analyzed using Illumina second-generation high-throughput sequencing technology on the MiSeq platform with related bioinformatics. The results revealed that the biochar increased the soil nutrient content of albic soil. The bacteria ACE indexes of treatments of rice straw biochar (SD) and corn straw biochar (SY) were increased by 3.10% and 2.06%, respectively, and the fungi ACE and Chao indices of SD were increased by 7.86% and 14.16%, respectively, compared to conventional control treatment with no biochar (SBCK). The numbers of bacterial and fungal operational taxonomic units (OUT) in SD and SY were increased, respectively, compared to that of SBCK. The relationship between soil bacteria and fungi in the biochar-treated groups was stronger than that in the SBCK. The bacterial and fungal populations were correlated with soil nutrients, which suggested that the impacts of biochar on the soil bacteria and fungi community were indirectly driven by alternation of soil nutrient characteristics. The addition of two types of biochar altered the soil microbial community structure and the effect of rice straw biochar treatment on SD was more pronounced. This study aimed to provide a reference and basic understanding for albic soil improvement by biochar, with good application prospects. Full article
(This article belongs to the Special Issue Biomaterials in China)
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19 pages, 45049 KiB  
Article
Size- and Surface- Dual Engineered Small Polyplexes for Efficiently Targeting Delivery of siRNA
by Shuang Liu, Shaohui Deng, Xiaoxia Li and Du Cheng
Molecules 2021, 26(11), 3238; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26113238 - 27 May 2021
Cited by 7 | Viewed by 2480
Abstract
Though siRNA-based therapy has achieved great progress, efficient siRNA delivery remains a challenge. Here, we synthesized a copolymer PAsp(-N=C-PEG)-PCys-PAsp(DETA) consisting of a poly(aspartate) block grafted with comb-like PEG side chains via a pH-sensitive imine bond (PAsp(-N=C-PEG) block), a poly(l-cysteine) block with [...] Read more.
Though siRNA-based therapy has achieved great progress, efficient siRNA delivery remains a challenge. Here, we synthesized a copolymer PAsp(-N=C-PEG)-PCys-PAsp(DETA) consisting of a poly(aspartate) block grafted with comb-like PEG side chains via a pH-sensitive imine bond (PAsp(-N=C-PEG) block), a poly(l-cysteine) block with a thiol group (PCys block), and a cationic poly(aspartate) block grafted with diethylenetriamine (PAsp(DETA) block). The cationic polymers efficiently complexed siRNA into polyplexes, showing a sandwich-like structure with a PAsp(-N=C-PEG) out-layer, a crosslinked PCys interlayer, and a complexing core of siRNA and PAsp(DETA). Low pH-triggered breakage of pH-sensitive imine bonds caused PEG shedding. The disulfide bond-crosslinking and pH-triggered PEG shedding synergistically decreased the polyplexes’ size from 75 nm to 26 nm. To neutralize excessive positive charges and introduce the targeting ligand, the polyplexes without a PEG layer were coated with an anionic copolymer modified with the targeting ligand lauric acid. The resulting polyplexes exhibited high transfection efficiency and lysosomal escape capacity. This study provides a promising strategy to engineer the size and surface of polyplexes, allowing long blood circulation and targeted delivery of siRNA. Full article
(This article belongs to the Special Issue Biomaterials in China)
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18 pages, 5077 KiB  
Article
Key Factor Study for Generic Long-Acting PLGA Microspheres Based on a Reverse Engineering of Vivitrol®
by Yabing Hua, Zengming Wang, Dan Wang, Xiaoming Lin, Boshi Liu, Hui Zhang, Jing Gao and Aiping Zheng
Molecules 2021, 26(5), 1247; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26051247 - 25 Feb 2021
Cited by 17 | Viewed by 3599
Abstract
The FDA (U.S. Food and Drug Administration) has approved only a negligible number of poly(lactide-co-glycolide) (PLGA)-based microsphere formulations, indicating the difficulty in developing a PLGA microsphere. A thorough understanding of microsphere formulations is essential to meet the challenge of developing innovative or generic [...] Read more.
The FDA (U.S. Food and Drug Administration) has approved only a negligible number of poly(lactide-co-glycolide) (PLGA)-based microsphere formulations, indicating the difficulty in developing a PLGA microsphere. A thorough understanding of microsphere formulations is essential to meet the challenge of developing innovative or generic microspheres. In this study, the key factors, especially the key process factors of the marketed PLGA microspheres, were revealed for the first time via a reverse engineering study on Vivitrol® and verified by the development of a generic naltrexone-loaded microsphere (GNM). Qualitative and quantitative similarity with Vivitrol®, in terms of inactive ingredients, was accomplished by the determination of PLGA. Physicochemical characterization of Vivitrol® helped to identify the critical process parameters in each manufacturing step. After being prepared according to the process parameters revealed by reverse engineering, the GNM demonstrated similarity to Vivitrol® in terms of quality attributes and in vitro release (f2 = 65.3). The research on the development of bioequivalent microspheres based on the similar technology of Vivitrol® will benefit the development of other generic or innovative microspheres. Full article
(This article belongs to the Special Issue Biomaterials in China)
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