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Development and Applications of Bioresorbable Materials

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Materials Chemistry".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 4917

Special Issue Editors


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Guest Editor
The Engineering-Meets-Medicine Laboratory, Stony Brook University, Stony Brook, NY, USA
Interests: smart-biomaterials and nano-biomaterials; biodegradable or bioresorbable materials; regenerative medicine for cardiovascular and orthopedic applications; innovative drug delivery device and platform; aging and neurodegenerative diseases like Alzheimer’s
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
The Engineering-Meets-Medicine Laboratory, Stony Brook University, Stony Brook, NY 11794, USA
Interests: biodegradable metals; surface coatings and functionalizations; immunomodulation; bioresorbable implants
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bioresorbable materials are a special class of materials that can fully degrade and dissolve in the body after fulfilling the designed functions. There are two main kinds of bioresorbable materials: bioresorbable polymers and bioresorbable metals, which are also known as biodegradable metals. Bioresorbable polymers have a long history and many of them have been approved for use by the U.S. Food and Drug Administration (FDA), e.g., poly-L-lactide (PLLA), poly(D,L-lactide) (PDLLA), poly(glycolic acid) (PGA) and their copolymers. Bioresorbable metals have been developed quickly with the preceded mechanical properties and durability. Magnesium (Mg), iron (Fe), and zinc (Zn) have so far been the three main bioresorbable metals. Bioresorbable medical devices made from these bioresorbable materials are designed to be temporarily implanted in the human body and would therefore avoid a second removal surgery, as is required for classic medical devices. This provides a unique opportunity to engineer different molecules and electrical and sensing components into implantable biodegradable systems. This Special Issue aims to present the latest works in the development and various applications of absorbable materials, to explore the most important findings, to explore more clinical applications, and to provide perspectives on the future direction of this field.

Dr. Donghui (Don) Zhu
Dr. Yingchao Su
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioresorbable polymers
  • bioresorbable metals
  • surface modifications
  • degradation
  • regenerative engineering
  • drug delivery
  • bioresorbable electronics

Published Papers (2 papers)

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Research

17 pages, 21061 KiB  
Article
Biodegradable and Biocompatible Silatrane Polymers
by Vladislav V. Istratov, Valerii A. Vasnev and Galy D. Markova
Molecules 2021, 26(7), 1893; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26071893 - 26 Mar 2021
Cited by 8 | Viewed by 2130
Abstract
In this study, new biodegradable and biocompatible amphiphilic polymers were obtained by modifying the peripheral hydroxyl groups of branched polyethers and polyesters with organosilicon substituents. The structures of the synthesized polymers were confirmed by NMR and GPC. Organosilicon moieties of the polymers were [...] Read more.
In this study, new biodegradable and biocompatible amphiphilic polymers were obtained by modifying the peripheral hydroxyl groups of branched polyethers and polyesters with organosilicon substituents. The structures of the synthesized polymers were confirmed by NMR and GPC. Organosilicon moieties of the polymers were formed by silatranes and trimethylsilyl blocks and displayed hydrophilic and hydrophobic properties, respectively. The effect of the ratio of hydrophilic to hydrophobic organosilicon structures on the surface activity and biological activity of macromolecules was studied, together with the effect on these activities of the macromolecules’ molecular weight and chemical structure. In particular, the critical micelle concentrations were determined, the effect of the structure of the polymers on their wetting with aqueous solutions on glass and parafilm was described, and the aggregation stability of emulsions was studied. Finally, the effect of the polymer structures on their antifungal activity and seed germination stimulation was examined. Full article
(This article belongs to the Special Issue Development and Applications of Bioresorbable Materials)
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18 pages, 2263 KiB  
Article
Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Amphiphilic Copolymers for Long-Acting Injectables: Synthesis, Non-Acylating Performance and In Vivo Degradation
by Silvio Curia, Feifei Ng, Marie-Emérentienne Cagnon, Victor Nicoulin and Adolfo Lopez-Noriega
Molecules 2021, 26(5), 1438; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26051438 - 06 Mar 2021
Cited by 2 | Viewed by 2364
Abstract
This article presents the evaluation of diblock and triblock poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) amphiphilic copolymers (PEG-PTMCs) as excipients for the formulation of long-acting injectables (LAIs). Copolymers were successfully synthesised through bulk ring-opening polymerisation. The concomitant formation of PTMC homopolymer could not be [...] Read more.
This article presents the evaluation of diblock and triblock poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) amphiphilic copolymers (PEG-PTMCs) as excipients for the formulation of long-acting injectables (LAIs). Copolymers were successfully synthesised through bulk ring-opening polymerisation. The concomitant formation of PTMC homopolymer could not be avoided irrespective of the catalyst amount, but the by-product could easily be removed by gel chromatography. Pure PEG-PTMCs undergo faster erosion in vivo than their corresponding homopolymer. Furthermore, these copolymers show outstanding stability compared to their polyester analogues when formulated with amine-containing reactive drugs, which makes them particularly suitable as LAIs for the sustained release of drugs susceptible to acylation. Full article
(This article belongs to the Special Issue Development and Applications of Bioresorbable Materials)
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