Special Issue "Chemical Biology of Antimicrobial Resistance"
Deadline for manuscript submissions: closed (31 August 2019).
Interests: glycosyltransferase; glysosidase; CAZy enzymes; enzymology; biocatalysts; carbohydrate chemistry; antimicrobial resistance; two component system; enzyme inhibitors; fluorinated carbohydrate; deubiquitinase inhibitor
A recent review of antimicrobial resistance (AMR), known as the O’Neill report, predicts deaths attributable to AMR will reach 10 million per year by 2050. Many hundreds of deaths have been caused by ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species). These pathogens have further evolved to multidrug-resistant (MDR), Klebsiella pneumoniae carbapenemase (KPC)-producing bacteria, Pseudomonas aeruginosa; methicillin-resistant Staphylococcus aureus (MRSA); and vancomycin-resistant Enterococci (VRE), for which currently no treatment options exist. Thus, there is an urgent need to develop new therapeutics against these deadly MDR pathogens using novel mechanisms of action. This Special Issue compiles research in the field of chemical biology to tackle this global problem that may lead to unprecedented catastrophes. The scope of these efforts includes molecular probes to study the mechanisms of antimicrobial resistance and antibiotic action, novel diagnostic methods and antibiotic molecules with new modes of action, and novel antibiotic strategies and targets. Manuscripts containing original research in the broad area of chemical biology are invited. I expect that this Special Issue will provide a valuable and unique insight into the urgent issue of antimicrobial resistance.
Dr. Seung Seo Lee
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Antimicrobial resistance
- Resistance mechanism
- New mode of action
- Antibiotic target
- Structure–activity relationship
- Molecular probe