Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.7
4.6
Journals
Molecules
Special Issues
Dendrimers for Biomedical Applications
molecules-logo
Submit to Molecules Review for Molecules Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Dendrimers for Biomedical Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Molecular Structure".

Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 8477

Special Issue Editors

Dr. José Vidal-Gancedo

E-Mail Website
Guest Editor
CSIC–Instituto de Ciencia de Materiales de Barcelona (ICMAB), Cerdanyola del Valles, Spain
Interests: organic radicals; electron paramagnetic resonance; radical dendrimers; spin-labeled gold nanoparticles; MRI; DNP
Special Issues, Collections and Topics in MDPI journals
Dr. Vega Lloveras

E-Mail Website
Guest Editor
CSIC–Instituto de Ciencia de Materiales de Barcelona (ICMAB), Cerdanyola del Valles, Spain
Interests: organic radicals; radical dendrimers; spin-labeled gold nanoparticles; electron paramagnetic resonance spectroscopy; magnetic resonance imaging (MRI); dynamic nuclear polarization (DNP); molecular switches
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The control over the structure design of dendrimers—their size, shape, branching length, and their surface functional groups—make these systems ideal for biomedical applications. The active agents may be encapsulated inside of the dendrimer, chemically attached or physically adsorbed onto the dendrimer surface, with the option of tailoring the carrier to the specific needs of the active material and its particular applications.

Twenty-seven years after the discovery of dendrimers by Fritz Vögtle, Svenson and Tomalia published the famous review “Dendrimers in Biomedical Applications—Reflections on the field”. Since then, the applications of dendrimers in biology and medicine have only grown. To traditional fields of application such as drug delivery, gene transfection or imaging agents, have been added new applications such as anti-atrophics, analgesics, anti-inflammatories, or in cancer therapy, odontology, among others.

The aim of the Special Issue on “Dendrimers for Biomedical Applications” is to be an open forum where researchers may share their investigations and findings in this promising field and, thanks to the open access platform, increase their visibility and chances to interact with industries and the production systems. Contributions to this issue, both in the form of original research or review articles, may cover all aspects of dendrimers for biomedical applications; studies with new methodologies or insights, are particularly welcome.

Dr. José Vidal-Gancedo
Dr. Vega Lloveras
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Dendrimers in biomedicine
  • Drug delivery
  • Gene transfection
  • Gene delivery
  • Imaging agents
  • Contrast agents for MRI
  • Biosensors

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Other

14 pages, 2615 KiB  
Article
Chelating Silicone Dendrons: Trying to Impact Organisms by Disrupting Ions at Interfaces
by Miguel Melendez-Zamudio, Kevina Chavda and Michael A. Brook
Molecules 2022, 27(6), 1869; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27061869 - 14 Mar 2022
Cited by 6 | Viewed by 1802
Abstract
The viability of pathogens at interfaces can be disrupted by the presence of (cationic) charge and chelating groups. We report on the synthesis of silicone dendrimers and linear polymers based on a motif of hexadentate ligands with the ability to capture and deliver [...] Read more.
The viability of pathogens at interfaces can be disrupted by the presence of (cationic) charge and chelating groups. We report on the synthesis of silicone dendrimers and linear polymers based on a motif of hexadentate ligands with the ability to capture and deliver metal ions. Mono-, di- or trialkoxysilanes are converted in G1 to analogous vinylsilicones and then, iteratively using the Piers-Rubinsztajn reaction and hydrosilylation, each vinyl group is transformed into a trivinyl cluster at G2. The thiol-ene reaction with cysteamine or 3-mercaptopropionic acid and the trivinyl cluster leads to hexadentate ligands 3 × N–S or 3 × HOOC–S. The compounds were shown to effectively capture a variety of metals ions. Copper ion chelation was pursued in more detail, because of its toxicity. On average, metal ions form chelates with 2.4 of the three ligands in a cluster. Upon chelation, viscous oils are converted to (very) soft elastomers. Most of the ions could be stripped from the elastomers using aqueous EDTA solutions, demonstrating the ability of the silicones to both sequester and deliver ions. However, complete ion removal is not observed; at equilibrium, the silicones remain ionically crosslinked. Full article
(This article belongs to the Special Issue Dendrimers for Biomedical Applications)
►▼ Show Figures

Graphical abstract

18 pages, 4012 KiB  
Article
Antimicrobial Peptide Dendrimers and Quorum-Sensing Inhibitors in Formulating Next-Generation Anti-Infection Cell Therapy Dressings for Burns
by Paris Jafari, Alexandre Luscher, Thissa Siriwardena, Murielle Michetti, Yok-Ai Que, Laurence G. Rahme, Jean-Louis Reymond, Wassim Raffoul, Christian Van Delden, Lee Ann Applegate and Thilo Köhler
Molecules 2021, 26(13), 3839; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26133839 - 24 Jun 2021
Cited by 4 | Viewed by 4502
Abstract
Multidrug resistance infections are the main cause of failure in the pro-regenerative cell-mediated therapy of burn wounds. The collagen-based matrices for delivery of cells could be potential substrates to support bacterial growth and subsequent lysis of the collagen leading to a cell therapy [...] Read more.
Multidrug resistance infections are the main cause of failure in the pro-regenerative cell-mediated therapy of burn wounds. The collagen-based matrices for delivery of cells could be potential substrates to support bacterial growth and subsequent lysis of the collagen leading to a cell therapy loss. In this article, we report the development of a new generation of cell therapy formulations with the capacity to resist infections through the bactericidal effect of antimicrobial peptide dendrimers and the anti-virulence effect of anti-quorum sensing MvfR (PqsR) system compounds, which are incorporated into their formulation. Anti-quorum sensing compounds limit the pathogenicity and antibiotic tolerance of pathogenic bacteria involved in the burn wound infections, by inhibiting their virulence pathways. For the first time, we report a biological cell therapy dressing incorporating live progenitor cells, antimicrobial peptide dendrimers, and anti-MvfR compounds, which exhibit bactericidal and anti-virulence properties without compromising the viability of the progenitor cells. Full article
(This article belongs to the Special Issue Dendrimers for Biomedical Applications)
►▼ Show Figures

Graphical abstract

Other

Jump to: Research

8 pages, 911 KiB  
Brief Report
Immunogenicity of Foot-and-Mouth Disease Virus Dendrimer Peptides: Need for a T-Cell Epitope and Ability to Elicit Heterotypic Responses
by Rodrigo Cañas-Arranz, Patricia de León, Sira Defaus, Elisa Torres, Mar Forner, María J. Bustos, David Andreu, Esther Blanco and Francisco Sobrino
Molecules 2021, 26(16), 4714; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26164714 - 04 Aug 2021
Cited by 2 | Viewed by 1523
Abstract
An approach based on a dendrimer display of B- and T-cell epitopes relevant for antibody induction has been shown to be effective as a foot-and-mouth disease (FMD) vaccine. B2T dendrimers combining two copies of the major FMD virus (FMDV) type O [...] Read more.
An approach based on a dendrimer display of B- and T-cell epitopes relevant for antibody induction has been shown to be effective as a foot-and-mouth disease (FMD) vaccine. B2T dendrimers combining two copies of the major FMD virus (FMDV) type O B-cell epitope (capsid proteinVP1 (140–158)) covalently linked to a heterotypic T-cell epitope from non-structural protein 3A (21–35), henceforth B2T-3A, has previously been shown to elicit high neutralizing antibody (nAb) titers and IFN-γ-producing cells in both mice and pigs. Here, we provide evidence that the B- and T-cell epitopes need to be tethered to a single molecular platform for successful T-cell help, leading to efficient nAb induction in mice. In addition, mice immunized with a non-covalent mixture of B2T-3A dendrimers containing the B-cell epitopes of FMDV types O and C induced similarly high nAb levels against both serotypes, opening the way for a multivalent vaccine platform against a variety of serologically different FMDVs. These findings are relevant for the design of vaccine strategies based on B- and T-cell epitope combinations. Full article
(This article belongs to the Special Issue Dendrimers for Biomedical Applications)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop