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3D Printing Technique for the Manufacturing of Drug Delivery Systems

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A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 8953

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Special Issue Editors

Prof. Dr. Ildikó Bácskay

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Guest Editor

Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei körút 98, 4032 Debrecen, Hungary
Interests: assessment of biocompatibility; drug delivery system formulation; application of macromolecules; characterization of dosage forms; in vitro dissolution studies; SEDDS
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Dr. Petra Arany

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Guest Editor

Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary
Interests: 3D printing; polymers

Special Issue Information

Dear Colleagues,

In modern pharmaceutical technology, many novel dug delivery systems are being developed. Connected to these formulations, the role of new manufacturing methods is nonquestionable. 3D printing is a new approach in personalized medication, and it is still searching for its own function in the pharmaceutical industry and in the medical therapy. The possibility of producing individualized implants and oral drug formulations holds potential for a variety of different medical purposes.

The aim of this Special Issue is to go deep into the challenges in 3D printing technologies, presenting new drug carriers for medical and pharmaceutical applications. As Guest Editors, we cordially invite you to contribute a research paper or review on any aspect related to this topic.

Ptof. Dr. Ildikó Bácskay
Dr. Petra Arany
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

3D printing
Drug delivery systems
Personalized medication

Published Papers (3 papers)

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Research

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31 pages, 2913 KiB

Open AccessArticle

In Vitro Tests of FDM 3D-Printed Diclofenac Sodium-Containing Implants

by Petra Arany, Ildikó Papp, Marianna Zichar, Máté Csontos, János Elek, Géza Regdon, Jr., István Budai, Mónika Béres, Rudolf Gesztelyi, Pálma Fehér, Zoltán Ujhelyi, Gábor Vasvári, Ádám Haimhoffer, Ferenc Fenyvesi, Judit Váradi, Vecsernyés Miklós and Ildikó Bácskay

Molecules 2020, 25(24), 5889; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules25245889 - 13 Dec 2020

Cited by 12 | Viewed by 3001

Abstract

One of the most promising emerging innovations in personalized medication is based on 3D printing technology. For use as authorized medications, 3D-printed products require different in vitro tests, including dissolution and biocompatibility investigations. Our objective was to manufacture implantable drug delivery systems using fused deposition modeling, and in vitro tests were performed for the assessment of these products. Polylactic acid, antibacterial polylactic acid, polyethylene terephthalate glycol, and poly(methyl methacrylate) filaments were selected, and samples with 16, 19, or 22 mm diameters and 0%, 5%, 10%, or 15% infill percentages were produced. The dissolution test was performed by a USP dissolution apparatus 1. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide dye (MTT)-based prolonged cytotoxicity test was performed on Caco-2 cells to certify the cytocompatibility properties. The implantable drug delivery systems were characterized by thermogravimetric and heatflow assay, contact angle measurement, scanning electron microscopy, microcomputed tomography, and Raman spectroscopy. Based on our results, it can be stated that the samples are considered nontoxic. The dissolution profiles are influenced by the material properties of the polymers, the diameter, and the infill percentage. Our results confirm the potential of fused deposition modeling (FDM) 3D printing for the manufacturing of different implantable drug delivery systems in personalized medicine and may be applied during surgical interventions. Full article

(This article belongs to the Special Issue 3D Printing Technique for the Manufacturing of Drug Delivery Systems)

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13 pages, 2278 KiB

Open AccessArticle

3D-Printed Gastroretentive Sustained Release Drug Delivery System by Applying Design of Experiment Approach

by Hyeon Myeong Jeong, Kwon-Yeon Weon, Beom Soo Shin and Soyoung Shin

Molecules 2020, 25(10), 2330; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules25102330 - 16 May 2020

Cited by 18 | Viewed by 3964

Abstract

This study aimed to develop a novel oral drug delivery system for gastroretentive sustained drug release by using a capsular device. A capsular device that can control drug release rates from the inner immediate release (IR) tablet while floating in the gastric fluid was fabricated and printed by a fused deposition modeling 3D printer. A commercial IR tablet of baclofen was inserted into the capsular device. The structure of the capsular device was optimized by applying a design of experiment approach to achieve sustained release of a drug while maintaining sufficient buoyancy. The 2-level factorial design was used to identify the optimal sustained release with three control factors: size, number, and height of drug-releasing holes of the capsular device. The drug delivery system was buoyant for more than 24 h and the average time to reach 80% dissolution (T₈₀) was 1.7–6.7 h by varying the control factors. The effects of the different control factors on the response factor, T₈₀, were predicted by using the equation of best fit. Finally, drug delivery systems with predetermined release rates were prepared with a mean prediction error ≤ 15.3%. This approach holds great promise to develop various controlled release drug delivery systems. Full article

(This article belongs to the Special Issue 3D Printing Technique for the Manufacturing of Drug Delivery Systems)

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Review

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23 pages, 4537 KiB

Open AccessReview

Emerging Multiscale Biofabrication Approaches for Bacteriotherapy

by Roberta Rovelli, Beatrice Cecchini, Lorenzo Zavagna, Bahareh Azimi, Claudio Ricci, Semih Esin, Mario Milazzo, Giovanna Batoni and Serena Danti

Molecules 2024, 29(2), 533; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules29020533 - 22 Jan 2024

Viewed by 1312

Abstract

Bacteriotherapy is emerging as a strategic and effective approach to treat infections by providing putatively harmless bacteria (i.e., probiotics) as antagonists to pathogens. Proper delivery of probiotics or their metabolites (i.e., post-biotics) can facilitate their availing of biomaterial encapsulation via innovative manufacturing technologies. This review paper aims to provide the most recent biomaterial-assisted strategies proposed to treat infections or dysbiosis using bacteriotherapy. We revised the encapsulation processes across multiscale biomaterial approaches, which could be ideal for targeting different tissues and suit diverse therapeutic opportunities. Hydrogels, and specifically polysaccharides, are the focus of this review, as they have been reported to better sustain the vitality of the live cells incorporated. Specifically, the approaches used for fabricating hydrogel-based devices with increasing dimensionality (D)—namely, 0D (i.e., particles), 1D (i.e., fibers), 2D (i.e., fiber meshes), and 3D (i.e., scaffolds)—endowed with probiotics, were detailed by describing their advantages and challenges, along with a future overlook in the field. Electrospinning, electrospray, and 3D bioprinting were investigated as new biofabrication methods for probiotic encapsulation within multidimensional matrices. Finally, examples of biomaterial-based systems for cell and possibly post-biotic release were reported. Full article

(This article belongs to the Special Issue 3D Printing Technique for the Manufacturing of Drug Delivery Systems)

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