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Special Issue "Bioactive Flavonoids and Xanthones: From Bench to Industry. Pharmaceutical, Cosmetic and Industrial Applications"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: 30 April 2022.

Special Issue Editors

Prof. Dr. Honorina Cidade
E-Mail Website
Guest Editor
1. Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal
2. CIIMAR—Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Novo Edifício do Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal
Interests: medicinal chemistry; organic synthesis; natural products; antitumor; flavonoids; antifouling
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Marta Correia-da-Silva
E-Mail Website1 Website2
Guest Editor
1. Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências, Químicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal
2. CIIMAR | Interdisciplinary Centre of Marine and Environmental Research, University of Porto. Novo Edifício do Terminal de Cruzeiros do Porto de Leixões. Avenida General Norton de Matos, s/n, 4450-208 Matosinhos, Portugal
Interests: medicinal chemistry; synthesis of sulfated and glycosylated small-molecule mimetics of heparin; discovery of biological activities for persulfated versus partially sulfated small molecules; antifouling studies of partially sulfated small molecules; antithrombotic studies of persulfated small molecules; structure–activity and structure–property relationship studies of bioactive small molecules
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Isabel Martins de Almeida
E-Mail Website1 Website2
Guest Editor
UCIBIO/REQUIMTE, MedTech-Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira nº 228, 4050-313 Porto, Portugal
Interests: antioxidants; natural products; sunscreens and anti-aging cosmetics; phototoxicity; photostability and photoprotection; mechanical and sensory characterization of topical formulations; patient centric design of topical products; health literacy in cosmetology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Flavonoids and xanthones are versatile scaffolds commonly found in nature, which have long been recognized for their wide range of biological and pharmacological activities, such as antimicrobial, anti-inflammatory, antitumor, antioxidant, antiaging, anti-browning and antifouling activities, which has led to their great interest as candidates for drug discovery, as well as other industrial applications. In the form of extracts and as pure compounds, flavonoids and xanthones have long been used in dermatological and cosmetic products. Considering the well-known biological potential of these classes of natural products, several studies have proposed their use as food additives due to their ability to preserve foods, to provide colour and flavour and to make dietary supplements, among other important industrial applications. This Special Issue aims to provide both updates and new perspectives on natural flavonoids and xanthones and their synthetic analogues for drug discovery, as well as candidates for other industrial applications. Original articles and short communications, as well as reviews of studies on this topic, are welcome.

Prof. Dr. Honorina Cidade
Prof. Dr. Marta Correia-da-Silva
Prof. Dr. Isabel Martins de Almeida
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Flavonoids
  • Xanthones
  • Biological activity
  • Natural Products
  • Synthesis
  • Industrial applications
  • Cosmetic applications
  • Food industry applications

Published Papers (2 papers)

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Research

Article
BP-M345, a New Diarylpentanoid with Promising Antimitotic Activity
Molecules 2021, 26(23), 7139; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26237139 - 25 Nov 2021
Viewed by 407
Abstract
Previously, we reported the in vitro growth inhibitory effect of diarylpentanoid BP-M345 on human cancer cells. Nevertheless, at that time, the cellular mechanism through which BP-M345 exerts its growth inhibitory effect remained to be explored. In the present work, we report its mechanism [...] Read more.
Previously, we reported the in vitro growth inhibitory effect of diarylpentanoid BP-M345 on human cancer cells. Nevertheless, at that time, the cellular mechanism through which BP-M345 exerts its growth inhibitory effect remained to be explored. In the present work, we report its mechanism of action on cancer cells. The compound exhibits a potent tumor growth inhibitory activity with high selectivity index. Mechanistically, it induces perturbation of the spindles through microtubule instability. As a consequence, treated cells exhibit irreversible defects in chromosome congression during mitosis, which induce a prolonged spindle assembly checkpoint-dependent mitotic arrest, followed by massive apoptosis, as revealed by live cell imaging. Collectively, the results indicate that the diarylpentanoid BP-M345 exerts its antiproliferative activity by inhibiting mitosis through microtubule perturbation and causing cancer cell death, thereby highlighting its potential as antitumor agent. Full article
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Article
Trends in the Use of Botanicals in Anti-Aging Cosmetics
Molecules 2021, 26(12), 3584; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26123584 - 11 Jun 2021
Cited by 4 | Viewed by 1783
Abstract
Botanical ingredients have been used for thousands of years in skincare for their convenience as well as the diversity and abundance in compounds with biological activity. Among these, polyphenols and especially flavonoids have gained increasing prominence due to their antioxidant and anti-inflammatory properties. [...] Read more.
Botanical ingredients have been used for thousands of years in skincare for their convenience as well as the diversity and abundance in compounds with biological activity. Among these, polyphenols and especially flavonoids have gained increasing prominence due to their antioxidant and anti-inflammatory properties. In this study, the most used botanical preparations in anti-aging products marketed in 2011 were determined. The analysis was repeated in 2018 for new and reformulated products. The scientific evidence for their application as active ingredients in anti-aging cosmetics and their flavonoid content was also compiled by searching in online scientific databases. Overall, in 2018, there was a noticeable increase in the use of botanical preparations in anti-aging cosmetics. However, the top three botanical species in both years were Vitis vinifera, Butyrospermum parkii, and Glycine soja, which is consistent with the greater amount of scientific evidence supporting their efficacy. Regarding the function of botanical preparations, there is a clear preference for DNA-protecting ingredients. The most prevalent flavonoids were flavan-3-ols, proanthocyanidins, and anthocyanins. This study provided an updated overview of the market trends regarding the use of botanicals in anti-aging products and documented the state of the art of scientific evidence for the most used plants. Full article
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