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Molecules
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Design and Synthesis of Transition Metal Catalysts
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Design and Synthesis of Transition Metal Catalysts

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 7478

Special Issue Editor

Prof. Dr. Zhuangzhi Shi

E-Mail Website
Guest Editor
State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
Interests: activation of inert chemical bonds; radical chemistry; boron chemistry; asymmetric catalysis

Special Issue Information

Dear Colleagues,

Transition metal catalysis represents the core of modern-day synthetic methodology, which is being extensively exploited in both laboratory and industrial settings. The coordination compounds of transition metals occupy a special place among the catalysts in organic chemistry because of their pronounced activity and their variety of properties. The catalytic features of transition metal complexes are under the strong influence of their ligands, which, in this way, become a useful tool to control the properties of the catalytic system. The design of the structure of a coordination compound (catalyst) is of crucial importance for its catalytic applications. Despite the great progress in understanding the structure–properties correlations, as well as the development of numerous synthetic processes, the catalytic parameters of many reactions are far from perfect, especially in the field of fine chemistry (such as asymmetric C–H functionalization, activation of small molecules, and others). 

This Special Issue is anticipated to showcase representative state-of-the-art developments in all aspects of transition metal-catalyzed reactions. Therefore, contributions are invited in all themes, including but not limited to reaction discovery, mechanistic study and catalyst design. Full papers, short communications, and review articles presenting and discussing the most recent trends in the field are welcomed.

Prof. Dr. Zhuangzhi Shi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metal catalysis
  • transition metal complexes
  • organic synthesis
  • bond activation
  • C–H activation
  • C–C formation
  • C–X formation

Published Papers (4 papers)

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Research

10 pages, 1687 KiB  
Article
A Computational Study on the Mechanism of Catalytic Cyclopropanation Reaction with Cobalt N-Confused Porphyrin: The Effects of Inner Carbon and Intramolecular Axial Ligand
by Osamu Iwanaga, Mayuko Miyanishi, Toshihiro Tachibana, Takaaki Miyazaki, Yoshihito Shiota, Kazunari Yoshizawa and Hiroyuki Furuta
Molecules 2022, 27(21), 7266; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27217266 - 26 Oct 2022
Viewed by 1431
Abstract
The factors that affect acceleration and high trans/cis selectivity in the catalytic cyclopropanation reaction of styrene with ethyl diazoacetate by cobalt N-confused porphyrin (NCP) complexes were investigated using density functional theory calculations. The reaction rate was primarily related to the energy [...] Read more.
The factors that affect acceleration and high trans/cis selectivity in the catalytic cyclopropanation reaction of styrene with ethyl diazoacetate by cobalt N-confused porphyrin (NCP) complexes were investigated using density functional theory calculations. The reaction rate was primarily related to the energy gap between the cobalt–carbene adduct intermediates, A and B, which was affected by the NCP skeletons and axial pyridine ligands more than the corresponding porphyrin complex. In addition, high trans/cis stereoselectivity was determined at the TS1 and, in part, in the isomerization process at the carbon-centered radical intermediates, Ctrans and Ccis. Full article
(This article belongs to the Special Issue Design and Synthesis of Transition Metal Catalysts)
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9 pages, 1410 KiB  
Article
Synthesis of Carbonyl-Containing Oxindoles via Ni-Catalyzed Reductive Aryl-Acylation and Aryl-Esterification of Alkenes
by Zhengtian Ding and Wangqing Kong
Molecules 2022, 27(18), 5899; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27185899 - 11 Sep 2022
Cited by 2 | Viewed by 1639
Abstract
Carbonyl-containing oxindoles are ubiquitous core structures present in many biologically active natural products and pharmaceutical molecules. Nickel-catalyzed reductive aryl-acylation of alkenes using aryl anhydrides or alkanoyl chlorides as acyl sources is developed, providing 3,3-disubstituted oxindoles bearing ketone functionality at the 3-position. Moreover, nickel-catalyzed [...] Read more.
Carbonyl-containing oxindoles are ubiquitous core structures present in many biologically active natural products and pharmaceutical molecules. Nickel-catalyzed reductive aryl-acylation of alkenes using aryl anhydrides or alkanoyl chlorides as acyl sources is developed, providing 3,3-disubstituted oxindoles bearing ketone functionality at the 3-position. Moreover, nickel-catalyzed reductive aryl-esterification of alkenes using chloroformate as ester sources is further developed, affording 3,3-disubstituted oxindoles bearing ester functionality at the 3-position. This strategy has the advantages of good yields and high functional group compatibility. Full article
(This article belongs to the Special Issue Design and Synthesis of Transition Metal Catalysts)
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9 pages, 1832 KiB  
Article
The Novel Function of Unsymmetrical Chiral CCN Pincer Nickel Complexes as Chemotherapeutic Agents Targeting Prostate Cancer Cells
by Jing-Jing Qu, Lin-Lin Shi, Yan-Bing Wang, Jing Yan, Tian Shao, Xin-Qi Hao, Jia-Xiang Wang, Hong-Yu Zhang, Jun-Fang Gong and Bing Song
Molecules 2022, 27(10), 3106; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27103106 - 12 May 2022
Cited by 2 | Viewed by 1402
Abstract
We report that the pincer nickel complexes display prostate cancer antitumor properties through inhibition of cell proliferation. Notably, they display better antitumor properties than cisplatin. Mechanistic studies reveal that these pincer nickel complexes trigger cell apoptosis, most likely due to cell cycle arrest. [...] Read more.
We report that the pincer nickel complexes display prostate cancer antitumor properties through inhibition of cell proliferation. Notably, they display better antitumor properties than cisplatin. Mechanistic studies reveal that these pincer nickel complexes trigger cell apoptosis, most likely due to cell cycle arrest. Interestingly, these complexes also inhibit androgen receptor (AR) and prostate-specific antigen (PSA) signaling, which are critical for prostate cancer survival and progression. Our study reveals a novel function of pincer nickel complexes as potential therapeutic drugs in prostate cancer. Full article
(This article belongs to the Special Issue Design and Synthesis of Transition Metal Catalysts)
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12 pages, 1056 KiB  
Article
SOMOphilic Alkynylation of Unreactive Alkenes Enabled by Iron-Catalyzed Hydrogen Atom Transfer
by Binlin Zhao, Tianxiang Zhu, Mengtao Ma and Zhuangzhi Shi
Molecules 2022, 27(1), 33; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27010033 - 22 Dec 2021
Cited by 2 | Viewed by 2426
Abstract
We report an efficient and practical iron-catalyzed hydrogen atom transfer protocol for assembling acetylenic motifs into functional alkenes. Diversities of internal alkynes could be obtained from readily available alkenes and acetylenic sulfones with excellent Markovnikov selectivity. An iron hydride hydrogen atom transfer catalytic [...] Read more.
We report an efficient and practical iron-catalyzed hydrogen atom transfer protocol for assembling acetylenic motifs into functional alkenes. Diversities of internal alkynes could be obtained from readily available alkenes and acetylenic sulfones with excellent Markovnikov selectivity. An iron hydride hydrogen atom transfer catalytic cycle was described to clarify the mechanism of this reaction. Full article
(This article belongs to the Special Issue Design and Synthesis of Transition Metal Catalysts)
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