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Microfluidics in Physical Chemistry Research Areas: Current Status and Recent Advances

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Physical Chemistry".

Deadline for manuscript submissions: closed (15 March 2023) | Viewed by 3672

Special Issue Editors

Department of Pharmacy, Kobenhavns Universitet, Copenhagen, Denmark
Interests: biophysical characterization of nano-self-assemblies, cubosomes, hexosomes; nanodispersions of inverse non-lamellar liquid crystalline phases; drug and functional food soft self-assembled nanocarriers; lyotropic liquid crystalline phases; microemulsions
Special Issues, Collections and Topics in MDPI journals
Institute of Chemistry and Casali Center of Applied Chemistry, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 91904, Israel
Interests: nanochemistry; sol-gel chemistry; organometallic chemistry; catalysis; green chemistry; micro- and nanoencapsulation
Special Issues, Collections and Topics in MDPI journals
INL—International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga, 4715-310 Braga, Portugal
Interests: gene delivery; lipid-nucleic acid nanoassemblies; surfactant and lipid self-assembly; phase behaviour of therapeutically relevant materials; microfluidics; small-angle scattering (SAXS and SANS); fluorescence cross-correlation spectroscopy; soft matter; nanomedicine; physical chemistry; colloidal science

Special Issue Information

Der Colleagues,

Microfluidic platforms are attractive for use in different technological applications, including tissue engineering, development of organ-on-chip platforms, single cell analysis, and continuous production of nanoparticles with controllable sizes (including nanocarriers for delivering drugs or functional foods, as well as vaccines). Here, it is worth noting that the emergence of microfluidics opens new potential applications and provides new opportunities in different research fields, including basic and applied physical chemistry research areas. We are pleased to launch the Special Issue "Microfluidics in Physical Chemistry Research Areas: Current Status and Recent Advances" for highlighting the recent increasing interest in design and use of versatile microfluidic platforms in materials science and physical chemistry research areas.

We aim to provide a forum for the dissemination of recent advances in the use of microfluidics for various investigations in Physical Chemistry, as well as highlight future opportunities for investigations under continuous and confined geometry conditions. 

This Special Issue will collect original research and review articles on microfluidics in physical chemistry research areas, including fundamental and applied research topics, computation, and the interface of physical chemistry, medicine, and biology.

Prof. Dr. Anan Yaghmur
Prof. Dr. Raed Abu-Reziq
Dr. Bruno Silva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Review

15 pages, 3113 KiB  
Review
Microfluidic Nanomaterial Synthesis and In Situ SAXS, WAXS, or SANS Characterization: Manipulation of Size Characteristics and Online Elucidation of Dynamic Structural Transitions
by Anan Yaghmur and Islam Hamad
Molecules 2022, 27(14), 4602; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27144602 - 19 Jul 2022
Cited by 9 | Viewed by 2806
Abstract
With the ability to cross biological barriers, encapsulate and efficiently deliver drugs and nucleic acid therapeutics, and protect the loaded cargos from degradation, different soft polymer and lipid nanoparticles (including liposomes, cubosomes, and hexosomes) have received considerable interest in the last three decades [...] Read more.
With the ability to cross biological barriers, encapsulate and efficiently deliver drugs and nucleic acid therapeutics, and protect the loaded cargos from degradation, different soft polymer and lipid nanoparticles (including liposomes, cubosomes, and hexosomes) have received considerable interest in the last three decades as versatile platforms for drug delivery applications and for the design of vaccines. Hard nanocrystals (including gold nanoparticles and quantum dots) are also attractive for use in various biomedical applications. Here, microfluidics provides unique opportunities for the continuous synthesis of these hard and soft nanomaterials with controllable shapes and sizes, and their in situ characterization through manipulation of the flow conditions and coupling to synchrotron small-angle X-ray (SAXS), wide-angle scattering (WAXS), or neutron (SANS) scattering techniques, respectively. Two-dimensional (2D) and three-dimensional (3D) microfluidic devices are attractive not only for the continuous production of monodispersed nanomaterials, but also for improving our understanding of the involved nucleation and growth mechanisms during the formation of hard nanocrystals under confined geometry conditions. They allow further gaining insight into the involved dynamic structural transitions, mechanisms, and kinetics during the generation of self-assembled nanostructures (including drug nanocarriers) at different reaction times (ranging from fractions of seconds to minutes). This review provides an overview of recently developed 2D and 3D microfluidic platforms for the continuous production of nanomaterials, and their simultaneous use in in situ characterization investigations through coupling to nanostructural characterization techniques (e.g., SAXS, WAXS, and SANS). Full article
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