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Frontiers of Boron Chemistry in 21th Century: From Fundamental Science to Applications - In Memory of Professor M. Frederick Hawthorne

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A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Inorganic Chemistry".

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 42155

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Special Issue Editors

Prof. Dr. Yinghuai Zhu

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Guest Editor

Sunshine Lake Pharma Co. Ltd., Dongguan 523871, China
Interests: design, synthesis and application of boron compounds and boron-based functional materials
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Narayan S. Hosmane

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Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, IL, USA
Interests: synthetic and structural chemistry of polyhedral boron cage biomolecules and nanostructured materials for cancer therapy; catalysis and extraction of radionuclides

Prof. Dr. Igor B. Sivaev

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Guest Editor

Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia
Interests: chemistry and application of polyhedral boron hydrides; including boranes; carboranes and metallacarboranes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue serves as a collective summary of the frontiers in boron chemistry emerging in the beginning of the 21th century. Boron chemistry has been growing intensively in the last decades and has found wide application in both academia and in industry, including in the fields of organic synthesis and materials science. Boron compounds increasingly play important roles in materials chemistry due to their unique physico-chemical properties, and thus, boron-containing photoactive products are being developed. Meanwhile, boron-containing compounds have also been used as efficient drugs in the treatment of various diseases, such as brain tumors and anti-inflammation.

All researchers who are working in these areas are cordially invited to contribute their original research papers or review articles to this Special Issue of Molecules, which will publish the latest research on the construction and evaluation of new drug candidates against various diseases and the identification of novel biological targets and therapeutic methods.

Prof. Dr. Narayan S. Hosmane
Prof. Dr. Yinghuai Zhu
Prof. Dr. Igor B. Sivaev
Guest Editors

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Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

boron chemistry
boron materials
boron drugs
boron catalysis
boron neutron capture therapy

Published Papers (14 papers)

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Research

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8 pages, 1952 KiB

Open AccessArticle

Zinc Borate Hydrolysis

by David M. Schubert

Molecules 2022, 27(18), 5768; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27185768 - 06 Sep 2022

Cited by 3 | Viewed by 1815

Abstract

The crystalline zinc borate phase ZnB₃O₄(OH)₃, known in commerce as 2ZnO·3B₂O₃·3.5H₂O, is an important industrial material used as a fire-retardant synergist in polymers, a source of micronutrients in agriculture, and a preservative in building materials. It lends durability to wood composite building materials by inhibiting attack by wood destroying organisms. The hydrolysis chemistry of this zinc borate is relevant to its industrial use. ZnB₃O₄(OH)₃ exhibits incongruent solubility, reversibly hydrolyzing at neutral pH to insoluble Zn(OH)₂ and soluble B(OH)₃. It is sparingly soluble with a room temperature solubility of 0.270 wt% in terms of its equivalent oxide components in solution, comprising 0.0267 wt% B₂O₃ and 0.003 wt% ZnO. Aspects of the hydrolysis chemistry of zinc borate under neutral pH conditions are discussed. Full article

(This article belongs to the Special Issue Frontiers of Boron Chemistry in 21th Century: From Fundamental Science to Applications - In Memory of Professor M. Frederick Hawthorne)

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10 pages, 905 KiB

Open AccessArticle

Synthesis of Cobalt Bis(Dicarbollide)—Curcumin Conjugates for Potential Use in Boron Neutron Capture Therapy

by Lyubov G. Dezhenkova, Anna A. Druzina, Yulia L. Volodina, Nadezhda V. Dudarova, Natalia A. Nekrasova, Olga B. Zhidkova, Mikhail A. Grin and Vladimir I. Bregadze

Molecules 2022, 27(14), 4658; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27144658 - 21 Jul 2022

Cited by 1 | Viewed by 1493

Abstract

A series of novel cobalt bis(dicarbollide)—curcumin conjugates were synthesized. Two conjugates were obtained through the nucleophilic ring-opening reaction of the 1,4-dioxane and tetrahydropyran derivatives of cobalt bis(dicarbollide) with the OH group of curcumin, and using two equiv. of the oxonium derivatives, two other conjugates containing two cobalt bis(dicarbollide) units per molecule were obtained. In contrast to curcumin, the conjugates obtained were found to be non-cytotoxic against both tumor and normal cell lines. The analysis of the intracellular accumulation of the conjugates by flow cytometry showed that all cobalt bis(dicarbollide)—curcumin conjugates entered HCT116 colorectal carcinoma cells in a time-dependent manner. New non-cytotoxic conjugates contain a large amount of boron atoms in the biomolecule and can potentially be used for further biological research into boron neutron capture therapy (BNCT). Full article

(This article belongs to the Special Issue Frontiers of Boron Chemistry in 21th Century: From Fundamental Science to Applications - In Memory of Professor M. Frederick Hawthorne)

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13 pages, 3657 KiB

Open AccessArticle

Self-Assembled Monolayer of Monomercaptoundecahydro-closo-dodecaborate on a Polycrystalline Gold Surface

by Martha L. Jiménez-González, Juan Pablo F. Rebolledo-Chávez, Marisela Cruz-Ramírez, René Antaño, Angel Mendoza, Narayan S. Hosmane, Lena Ruiz-Azuara, José Luis Hernández-López and Luis Ortiz-Frade

Molecules 2022, 27(8), 2496; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27082496 - 12 Apr 2022

Viewed by 1846

Abstract

In this work, we present an electrochemical study of the boron cage monomercaptoundecahydro-closo-dodecaborate [B₁₂H₁₁SH]²⁻ in solution and in a self-assembled monolayer over a polycrystalline gold electrode. Cyclic voltammetry of the anion [B₁₂H₁₁SH]²⁻ in solution showed a shift in the peak potentials related to the redox processes of gold hydroxides, which evidences the interaction between the boron cage and the gold surface. For an Au electrode modified with the anion [B₁₂H₁₁SH]²⁻, cyclic voltammetry response of the probe Fe(CN)₆³⁻/Fe(CN)₆⁴⁻ showed a ΔEp value typical for a surface modification. Electrochemical impedance spectroscopy presented R_tc and C_dl values related to the formation of a self-assembled monolayer (SAM). A comparison of electrochemical responses of a modified electrode with thioglycolic acid (TGA) reveals that the boron cage [B₁₂H₁₁SH]²⁻ diminishes the actives sites over the Au surface due to the steric effects. Differential capacitance measurements for bare gold electrode and those modified with [B₁₂H₁₁SH]²⁻ and (TGA), indicate that bulky thiols enhance charge accumulation at the electrode–solution interface. In addition to electrochemical experiments, DFT calculations and surface plasmon resonance measurements (SPR) were carried out to obtain quantum chemical descriptors and to evaluate the molecular length and the dielectric constant of the Boron cage. From SPR experiments, the adsorption kinetics of [B₁₂H₁₁SH]²⁻ were studied. The data fit for a Langmuir kinetic equation, typical for the formation of a monolayer. Full article

(This article belongs to the Special Issue Frontiers of Boron Chemistry in 21th Century: From Fundamental Science to Applications - In Memory of Professor M. Frederick Hawthorne)

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13 pages, 565 KiB

Open AccessArticle

Assessment of Agroeconomic Indicators of Sesamum indicum L. as Influenced by Application of Boron at Different Levels and Plant Growth Stages

by Salwinder Singh Dhaliwal, Vivek Sharma, Arvind Kumar Shukla, Vibha Verma, Sanjib Kumar Behera, Prabhjodh Singh Sandhu, Kamaljit Kaur, Ahmed Gaber, Yusuf S. Althobaiti, Abdelhadi A. Abdelhadi and Akbar Hossain

Molecules 2021, 26(21), 6699; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26216699 - 05 Nov 2021

Cited by 8 | Viewed by 1676

Abstract

To achieve the nutritional target of human food, boron (B) has been described as an essential mineral in determining seed and theoretical oil yield of Sesamum indicum L. The research to increase its cultivation is garnering attention due to its high oil content, quality and its utilization for various purposes, which include human nutrition as well as its use in the food industry. For this, a two-year field experiment was performed at PAU, Punjab, India to determine the effect of different concentrations of foliar-applied B (20, 30 and 40 mg L⁻¹) and different growth stages of crop, i.e., we measured the effects on agroeconomic indicators and certain quality parameters of sesame using different concentrations of B applied at the flowering and capsule formation stages as compared to using water spray and untreated plants. Water spray did not significantly affect the studied parameters. However, B application significantly increased the yield, uptake, antioxidant activity (AOA) and theoretical oil content (TOC) compared to those of untreated plants. The maximum increase in seed yield (26.75%), B seed and stover uptake (64.08% and 69.25%, respectively) as well as highest AOA (69.41%) and benefit to cost ratio (B:C ratio 2.63) was recorded when B was applied at 30 mg L⁻¹ at the flowering and capsule formation stages. However, the maximum sesame yield and B uptake were recorded when B was applied at a rate of 30 mg L⁻¹. A significant increase in TOC was also recorded with a B application rate of 30 mg L⁻¹. For efficiency indices, the higher values of boron agronomic efficiency (BAE) and boron crop recovery efficiency (BCRE) were recorded when B was applied at 20 mg L⁻¹ (5.25 and 30.56, respectively) and 30 mg L⁻¹ (4.96 and 26.11, respectively) at the flowering and capsule formation stages. In conclusion, application of B @ 30 mg L⁻¹ at the flowering and capsule formation stages seemed a viable technique to enhance yield, B uptake and economic returns of sesame. Full article

(This article belongs to the Special Issue Frontiers of Boron Chemistry in 21th Century: From Fundamental Science to Applications - In Memory of Professor M. Frederick Hawthorne)

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16 pages, 2297 KiB

Open AccessArticle

Synthesis of Boronated Amidines by Addition of Amines to Nitrilium Derivative of Cobalt Bis(Dicarbollide)

by Ekaterina V. Bogdanova, Marina Yu. Stogniy, Kyrill Yu. Suponitsky, Igor B. Sivaev and Vladimir I. Bregadze

Molecules 2021, 26(21), 6544; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26216544 - 29 Oct 2021

Cited by 6 | Viewed by 1850

Abstract

A series of novel cobalt bis(dicarbollide) based amidines were synthesized by the nucleophilic addition of primary and secondary amines to highly activated B-N⁺≡C–R triple bond of the propionitrilium derivative [8-EtC≡N-3,3′-Co(1,2-C₂B₉H₁₀)(1′,2′-C₂B₉H₁₁)]. The reactions with primary amines result in the formation of mixtures of E and Z isomers of amidines, whereas the reactions with secondary amines lead selectively to the E-isomers. The crystal molecular structures of E-[8-EtC(NMe₂)=HN-3,3′-Co(1,2-C₂B₉H₁₀)(1′,2′-C₂B₉H₁₁)], E-[8-EtC(NEt₂)=HN-3,3′-Co(1,2- C₂B₉H₁₀)(1′,2′-C₂B₉H₁₁)] and E-[8-EtC(NC₅H₁₀)=HN-3,3′-Co(1,2-C₂B₉H₁₀)(1′,2′-C₂B₉H₁₁)] were determined by single crystal X-ray diffraction. Full article

(This article belongs to the Special Issue Frontiers of Boron Chemistry in 21th Century: From Fundamental Science to Applications - In Memory of Professor M. Frederick Hawthorne)

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15 pages, 1212 KiB

Open AccessArticle

Modulation of γ-Secretase Activity by a Carborane-Based Flurbiprofen Analogue

by Stefan Saretz, Gabriele Basset, Liridona Useini, Markus Laube, Jens Pietzsch, Dijana Drača, Danijela Maksimović-Ivanić, Johannes Trambauer, Harald Steiner and Evamarie Hey-Hawkins

Molecules 2021, 26(10), 2843; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26102843 - 11 May 2021

Cited by 10 | Viewed by 2469

Abstract

All over the world, societies are facing rapidly aging populations combined with a growing number of patients suffering from Alzheimer’s disease (AD). One focus in pharmaceutical research to address this issue is on the reduction of the longer amyloid-β (Aβ) fragments in the brain by modulation of γ-secretase, a membrane-bound protease. R-Flurbiprofen (tarenflurbil) was studied in this regard but failed to show significant improvement in AD patients in a phase 3 clinical trial. This was mainly attributed to its low ability to cross the blood–brain barrier (BBB). Here, we present the synthesis and in vitro evaluation of a racemic meta-carborane analogue of flurbiprofen. By introducing the carborane moiety, the hydrophobicity could be shifted into a more favourable range for the penetration of the blood–brain barrier, evident by a logD_7.4 value of 2.0. Furthermore, our analogue retained γ-secretase modulator activity in comparison to racemic flurbiprofen in a cell-based assay. These findings demonstrate the potential of carboranes as phenyl mimetics also in AD research. Full article

(This article belongs to the Special Issue Frontiers of Boron Chemistry in 21th Century: From Fundamental Science to Applications - In Memory of Professor M. Frederick Hawthorne)

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13 pages, 2849 KiB

Open AccessArticle

Influence of Electronic Environment on the Radiative Efficiency of 9-Phenyl-9H-carbazole-Based ortho-Carboranyl Luminophores

by Seok Ho Lee, Ji Hye Lee, Min Sik Mun, Sanghee Yi, Eunji Yoo, Hyonseok Hwang and Kang Mun Lee

Molecules 2021, 26(6), 1763; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26061763 - 21 Mar 2021

Cited by 4 | Viewed by 2241

Abstract

The photophysical properties of closo-ortho-carboranyl-based donor–acceptor dyads are known to be affected by the electronic environment of the carborane cage but the influence of the electronic environment of the donor moiety remains unclear. Herein, four 9-phenyl-9H-carbazole-based closo-ortho-carboranyl compounds (1F, 2P, 3M, and 4T), in which an o-carborane cage was appended at the C3-position of a 9-phenyl-9H-carbazole moiety bearing various functional groups, were synthesized and fully characterized using multinuclear nuclear magnetic resonance spectroscopy and elemental analysis. Furthermore, the solid-state molecular structures of 1F and 4T were determined by X-ray diffraction crystallography. For all the compounds, the lowest-energy absorption band exhibited a tail extending to 350 nm, attributable to the spin-allowed π–π* transition of the 9-phenyl-9H-carbazole moiety and weak intramolecular charge transfer (ICT) between the o-carborane and the carbazole group. These compounds showed intense yellowish emission (λ_em = ~540 nm) in rigid states (in tetrahydrofuran (THF) at 77 K and in films), whereas considerably weak emission was observed in THF at 298 K. Theoretical calculations on the first excited states (S₁) of the compounds suggested that the strong emission bands can be assigned to the ICT transition involving the o-carborane. Furthermore, photoluminescence experiments in THF‒water mixtures demonstrated that aggregation-induced emission was responsible for the emission in rigid states. Intriguingly, the quantum yields and radiative decay constants in the film state were gradually enhanced with the increasing electron-donating ability of the substituent on the 9-phenyl group (‒F for 1F < ‒H for 2P < ‒CH₃ for 3M < ‒C(CH₃)₃ for 4T). These features indicate that the ICT-based radiative decay process in rigid states is affected by the electronic environment of the 9-phenyl-9H-carbazole group. Consequently, the efficient ICT-based radiative decay of o-carboranyl compounds can be achieved by appending the o-carborane cage with electron-rich aromatic systems. Full article

(This article belongs to the Special Issue Frontiers of Boron Chemistry in 21th Century: From Fundamental Science to Applications - In Memory of Professor M. Frederick Hawthorne)

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14 pages, 2645 KiB

Open AccessArticle

Synthesis and Structure of Nido-Carboranyl Azide and Its “Click” Reactions

by Anna A. Druzina, Olga B. Zhidkova, Nadezhda V. Dudarova, Irina D. Kosenko, Ivan V. Ananyev, Sergey V. Timofeev and Vladimir I. Bregadze

Molecules 2021, 26(3), 530; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26030530 - 20 Jan 2021

Cited by 7 | Viewed by 2554

Abstract

Novel zwitter-ionic nido-carboranyl azide 9-N₃(CH₂)₃Me₂N-nido-7,8-C₂B₉H₁₁ was prepared by the reaction of 9-Cl(CH₂)₃Me₂N-nido-7,8-C₂B₉H₁₁ with NaN [...] Read more.

Novel zwitter-ionic nido-carboranyl azide 9-N₃(CH₂)₃Me₂N-nido-7,8-C₂B₉H₁₁ was prepared by the reaction of 9-Cl(CH₂)₃Me₂N-nido-7,8-C₂B₉H₁₁ with NaN₃. The solid-state molecular structure of nido-carboranyl azide was determined by single-crystal X-ray diffraction. 9-N₃(CH₂)₃Me₂N-nido-7,8-C₂B₉H₁₁ was used for the copper(I)-catalyzed azide-alkyne cycloaddition with phenylacetylene, alkynyl-3β-cholesterol and cobalt/iron bis(dicarbollide) terminal alkynes to form the target 1,2,3-triazoles. The nido-carborane-cholesterol conjugate 9-3β-Chol-O(CH₂)C-CH-N₃(CH₂)₃Me₂N-nido-7,8-C₂B₉H₁₁ with charge-compensated group in a linker can be used as a precursor for preparation of liposomes for Boron Neutron Capture Therapy (BNCT). A series of novel zwitter-ionic boron-enriched cluster compounds bearing a 1,2,3-triazol-metallacarborane-carborane conjugated system was synthesized. Prepared conjugates contain a large amount of boron atom in the biomolecule and potentially can be used for BNCT. Full article

(This article belongs to the Special Issue Frontiers of Boron Chemistry in 21th Century: From Fundamental Science to Applications - In Memory of Professor M. Frederick Hawthorne)

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6 pages, 1058 KiB

Open AccessCommunication

The First Nickelacarborane with closo-nido Structure

by Ekaterina P. Andreichuk, Sergey A. Anufriev, Kyrill Yu. Suponitsky and Igor B. Sivaev

Molecules 2020, 25(24), 6009; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules25246009 - 18 Dec 2020

Cited by 3 | Viewed by 1548

Abstract

The first nickelacarborane with closo-nido structure [10′,11′-(Py)₂-3,9′-Ni(1,2-C₂B₉H₁₁)(7′,8′-C₂B₈H₈)] was isolated from the reaction of nickel(IV) bis(dicarbollide) with pyridine. The molecular structure of this complex was determined by single crystal X-ray diffraction. The nickel atom is a common vertex for the closo-NiC₂B₉ cluster and the nido-NC₂B₈ cluster where it is located together with carbon atoms in the open NiC₂B₂ pentagonal face. It is assumed that its formation proceeds through the nucleophile-induced removal of the B(6)H vertex followed by rearrangement of the forming 11-vertex cluster, which most likely proceeds through a sequence of closing and opening reactions. Full article

(This article belongs to the Special Issue Frontiers of Boron Chemistry in 21th Century: From Fundamental Science to Applications - In Memory of Professor M. Frederick Hawthorne)

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Review

Jump to: Research

29 pages, 2526 KiB

Open AccessReview

The Role of Microbiome in Brain Development and Neurodegenerative Diseases

by Varsha Nandwana, Nitesh K. Nandwana, Yogarupa Das, Mariko Saito, Tanisha Panda, Sasmita Das, Frankis Almaguel, Narayan S. Hosmane and Bhaskar C. Das

Molecules 2022, 27(11), 3402; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27113402 - 25 May 2022

Cited by 34 | Viewed by 6738

Abstract

Hundreds of billions of commensal microorganisms live in and on our bodies, most of which colonize the gut shortly after birth and stay there for the rest of our lives. In animal models, bidirectional communications between the central nervous system and gut microbiota (Gut–Brain Axis) have been extensively studied, and it is clear that changes in microbiota composition play a vital role in the pathogenesis of various neurodevelopmental and neurodegenerative disorders, such as Autism Spectrum Disorder, Alzheimer’s disease, Parkinson’s disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, anxiety, stress, and so on. The makeup of the microbiome is impacted by a variety of factors, such as genetics, health status, method of delivery, environment, nutrition, and exercise, and the present understanding of the role of gut microbiota and its metabolites in the preservation of brain functioning and the development of the aforementioned neurological illnesses is summarized in this review article. Furthermore, we discuss current breakthroughs in the use of probiotics, prebiotics, and synbiotics to address neurological illnesses. Moreover, we also discussed the role of boron-based diet in memory, boron and microbiome relation, boron as anti-inflammatory agents, and boron in neurodegenerative diseases. In addition, in the coming years, boron reagents will play a significant role to improve dysbiosis and will open new areas for researchers. Full article

(This article belongs to the Special Issue Frontiers of Boron Chemistry in 21th Century: From Fundamental Science to Applications - In Memory of Professor M. Frederick Hawthorne)

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36 pages, 78868 KiB

Open AccessReview

Boron Chemicals in Drug Discovery and Development: Synthesis and Medicinal Perspective

by Bhaskar C. Das, Nitesh K. Nandwana, Sasmita Das, Varsha Nandwana, Mohammed Adil Shareef, Yogarupa Das, Mariko Saito, Louis M. Weiss, Frankis Almaguel, Narayan S. Hosmane and Todd Evans

Molecules 2022, 27(9), 2615; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27092615 - 19 Apr 2022

Cited by 42 | Viewed by 5176

Abstract

A standard goal of medicinal chemists has been to discover efficient and potent drug candidates with specific enzyme-inhibitor abilities. In this regard, boron-based bioactive compounds have provided amphiphilic properties to facilitate interaction with protein targets. Indeed, the spectrum of boron-based entities as drug candidates against many diseases has grown tremendously since the first clinically tested boron-based drug, Velcade. In this review, we collectively represent the current boron-containing drug candidates, boron-containing retinoids, benzoxaboroles, aminoboronic acid, carboranes, and BODIPY, for the treatment of different human diseases.In addition, we also describe the synthesis, key structure–activity relationship, and associated biological activities, such as antimicrobial, antituberculosis, antitumor, antiparasitic, antiprotozoal, anti-inflammatory, antifolate, antidepressant, antiallergic, anesthetic, and anti-Alzheimer’s agents, as well as proteasome and lipogenic inhibitors. This compilation could be very useful in the exploration of novel boron-derived compounds against different diseases, with promising efficacy and lesser side effects. Full article

(This article belongs to the Special Issue Frontiers of Boron Chemistry in 21th Century: From Fundamental Science to Applications - In Memory of Professor M. Frederick Hawthorne)

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30 pages, 16354 KiB

Open AccessReview

Recent Advances in BODIPY Compounds: Synthetic Methods, Optical and Nonlinear Optical Properties, and Their Medical Applications

by Prabhuodeyara M. Gurubasavaraj, Vinodkumar P. Sajjan, Blanca M. Muñoz-Flores, Víctor M. Jiménez Pérez and Narayan S. Hosmane

Molecules 2022, 27(6), 1877; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27061877 - 14 Mar 2022

Cited by 14 | Viewed by 3437

Abstract

Organoboron compounds are attracting immense research interest due to their wide range of applications. Particularly, low-coordinate organoboron complexes are receiving more attention due to their improbable optical and nonlinear optical properties, which makes them better candidates for medical applications. In this review, we summarize the various synthetic methods including multicomponent reactions, microwave-assisted and traditional pathways of organoboron complexes, and their optical and nonlinear properties. This review also includes the usage of organoboron complexes in various fields including biomedical applications. Full article

(This article belongs to the Special Issue Frontiers of Boron Chemistry in 21th Century: From Fundamental Science to Applications - In Memory of Professor M. Frederick Hawthorne)

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15 pages, 1783 KiB

Open AccessReview

Recent Advances in Crystalline Oxidopolyborate Complexes of d-Block or p-Block Metals: Structural Aspects, Syntheses, and Physical Properties

by Shu-Sheng Xin, Ming-Hua Zhou, Michael A. Beckett and Chun-Yang Pan

Molecules 2021, 26(13), 3815; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26133815 - 22 Jun 2021

Cited by 8 | Viewed by 1696

Abstract

Crystalline materials containing hybrid inorganic–organic metal borates (complexes with oxidoborate ligands) display a variety of novel framework building blocks. The structural aspects of these hybrid metallaoxidoborates containing Cd^(II), Co^(II), Cu^(II), Ga^(III), In^(III), Mn^(II), Ni^(II) or Zn^(II) metal centers are discussed in this review. The review describes synthetic approaches to these hybrid materials, their physical properties, their spectroscopic properties and their potential applications. Full article

(This article belongs to the Special Issue Frontiers of Boron Chemistry in 21th Century: From Fundamental Science to Applications - In Memory of Professor M. Frederick Hawthorne)

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26 pages, 7451 KiB

Open AccessReview

Organoboron Compounds: Effective Antibacterial and Antiparasitic Agents

by Paolo Saul Coghi, Yinghuai Zhu, Hongming Xie, Narayan S. Hosmane and Yingjun Zhang

Molecules 2021, 26(11), 3309; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26113309 - 31 May 2021

Cited by 27 | Viewed by 5656

Abstract

The unique electron deficiency and coordination property of boron led to a wide range of applications in chemistry, energy research, materials science and the life sciences. The use of boron-containing compounds as pharmaceutical agents has a long history, and recent developments have produced encouraging strides. Boron agents have been used for both radiotherapy and chemotherapy. In radiotherapy, boron neutron capture therapy (BNCT) has been investigated to treat various types of tumors, such as glioblastoma multiforme (GBM) of brain, head and neck tumors, etc. Boron agents playing essential roles in such treatments and other well-established areas have been discussed elsewhere. Organoboron compounds used to treat various diseases besides tumor treatments through BNCT technology have also marked an important milestone. Following the clinical introduction of bortezomib as an anti-cancer agent, benzoxaborole drugs, tavaborole and crisaborole, have been approved for clinical use in the treatments of onychomycosis and atopic dermatitis. Some heterocyclic organoboron compounds represent potentially promising candidates for anti-infective drugs. This review highlights the clinical applications and perspectives of organoboron compounds with the natural boron atoms in disease treatments without neutron irradiation. The main topic focuses on the therapeutic applications of organoboron compounds in the diseases of tuberculosis and antifungal activity, malaria, neglected tropical diseases and cryptosporidiosis and toxoplasmosis. Full article

(This article belongs to the Special Issue Frontiers of Boron Chemistry in 21th Century: From Fundamental Science to Applications - In Memory of Professor M. Frederick Hawthorne)

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