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Special Issue "State-of-the-Art in Molybdenum Cofactor Research"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: 31 March 2022.

Special Issue Editors

Prof. Dr. Ralf-Rainer Mendel
E-Mail Website
Guest Editor
Department of Molecular and Cell Biology of Plants, Institute for Plant Biology, Faculty of Life Sciences, Technical University of Braunschweig, 38106 Braunschweig, Germany
Interests: molybdenum cofactor; molybdenum metabolism
Dr. Tobias Kruse
E-Mail Website
Guest Editor
Department of Molecular and Cell Biology of Plants, Institute for Plant Biology, Faculty of Life Sciences, Technical University of Braunschweig, 38106 Braunschweig, Germany
Interests: molybdenum cofactor; molybdenum metabolism

Special Issue Information

Dear Colleagues,

The pterin-based molybdenum cofactor (Moco) and the iron-molybdenum cofactor (FeMoco) of nitrogenase are old inventions of nature. LUCA, the last universal common ancestor of a living cell, was able to synthesize these essential prosthetic groups. Bacteria host over fifty molybdenum enzymes, while eukaryotes only host five. Loss of Moco biosynthesis is lethal for most organisms.

This Special Issue aims at illustrating the most recent and pertinent developments in Moco and FeMoco research in eukaryotic organisms and in bacteria, respectively. This will include the biosynthesis pathways of both cofactors, molybdenum uptake in cells, the mechanisms of insertion of molybdenum into the cofactor scaffolds, the carrier and storage proteins of Moco following its biosynthesis, and the insertion of cofactors into their target enzymes. Special attention will be paid to the areas of Moco and FeMoco spectroscopy, model compound chemistry, chemical synthesis of Moco, and the structural biology of Moco and FeMoco. The key role of human Moco deficiency and its therapy will also be highlighted. We are not focusing on molybdenum enzymes with their function, biochemistry, and their structural biology.

Communications, full papers, and reviews on the abovementioned topics are particularly welcome.

Prof. Dr. Ralf-Rainer Mendel
Dr. Tobias Kruse
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Molybdenum cofactor (Moco)
  • Iron molybdenum cofactor (FeMoco)
  • Moco biosynthesis
  • FeMoco biosynthesis
  • Molybdate uptake
  • Molybdate storage
  • Moco carrier proteins
  • Moco storage
  • Insertion of Moco/FeMoco into target enzymes
  • Moco/FeMoco spectroscopy
  • Model compounds
  • Chemistry of Moco and FeMoco
  • Human Moco deficiency

Published Papers

This special issue is now open for submission.
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