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Microalgae Secondary Metabolites-Bioactivity Determination using Innovative Approach of Omics

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 3889

Special Issue Editors


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Guest Editor
Centre ALGATECH, Institute of Microbiology, Czech Academy of Sciences, Novohradska 237 – Opatovicky mlyn, CZ 379 01 Trebon, Czech Republic
Interests: isolation and structural elucidation of new leads compounds as anti-microbial, anti-inflammatory, and anti-cancer drugs; exploration of the QSI and the QS molecules for development of antivirulence drug therapy; cyanobacteria as a source of novel lead compounds and toxins; advances in the detection of toxins in fresh water
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Centre ALGATECH, Institute of Microbiology, Czech Academy of Sciences, Novohradska 237 – Opatovicky mlyn, CZ 379 01 Trebon, Czech Republic
Interests: isolation and structural elucidation of new leads compounds as anti-microbial, anti-inflammatory, and anti-cancer drugs; exploration of the QSI and the QS molecules for development of antivirulence drug therapy; cyanobacteria as a source of novel lead compounds and toxins; advances in the detection of toxins in fresh water
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microalgae have kept developing new adaptation features and defense mechanisms; one of these survival strategies is the production of a vast variety of secondary metabolites, exhibiting a broad spectrum of biological activities and properties, including peptides, lipopeptides, polyketides, alkaloids, lipids, and terpenoids. When growth conditions are advantageous, microalgae proliferate, resulting in overgrown populations known as algal blooms, which can be harmful for aquatic life as well as for human health because of the toxins they produce. The recent advancement in the field of metabolomics and genomics has accelerated the discovery of new bioactive molecules and toxins. Additionally, the role of bacterial–microalgal interactions on the physiological control of metabolite production towards the development of co-habitation in non-axenic microalgae are scantly reported.

The current Special Issue of Molecules welcomes any research highlighting natural algal products, including the molecular mechanism behind the regulation of metabolite production. Moreover, studies describing the biosynthesis of these compounds are especially encouraged.

Dr. Kumar Saurav
Dr. Subhasish Saha
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cyanobacteria
  • Anti-microbial activity
  • Biosynthesis of bioactive lead molecules
  • Anti-Virulence drug therapy
  • Toxins production and its detection
  • Host-microbe interaction mechanism
  • Dereplication strategy for metabolites

Published Papers (1 paper)

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Research

12 pages, 1935 KiB  
Article
Discovery of Unusual Cyanobacterial Tryptophan-Containing Anabaenopeptins by MS/MS-Based Molecular Networking
by Subhasish Saha, Germana Esposito, Petra Urajová, Jan Mareš, Daniela Ewe, Alessia Caso, Markéta Macho, Kateřina Delawská, Andreja Kust, Pavel Hrouzek, Josef Juráň, Valeria Costantino and Kumar Saurav
Molecules 2020, 25(17), 3786; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules25173786 - 20 Aug 2020
Cited by 11 | Viewed by 3385
Abstract
Heterocytous cyanobacteria are among the most prolific sources of bioactive secondary metabolites, including anabaenopeptins (APTs). A terrestrial filamentous Brasilonema sp. CT11 collected in Costa Rica bamboo forest as a black mat, was studied using a multidisciplinary approach: genome mining and HPLC-HRMS/MS coupled with [...] Read more.
Heterocytous cyanobacteria are among the most prolific sources of bioactive secondary metabolites, including anabaenopeptins (APTs). A terrestrial filamentous Brasilonema sp. CT11 collected in Costa Rica bamboo forest as a black mat, was studied using a multidisciplinary approach: genome mining and HPLC-HRMS/MS coupled with bioinformatic analyses. Herein, we report the nearly complete genome consisting of 8.79 Mbp with a GC content of 42.4%. Moreover, we report on three novel tryptophan-containing APTs; anabaenopeptin 788 (1), anabaenopeptin 802 (2), and anabaenopeptin 816 (3). Furthermore, the structure of two homologues, i.e., anabaenopeptin 802 (2a) and anabaenopeptin 802 (2b), was determined by spectroscopic analysis (NMR and MS). Both compounds were shown to exert weak to moderate antiproliferative activity against HeLa cell lines. This study also provides the unique and diverse potential of biosynthetic gene clusters and an assessment of the predicted chemical space yet to be discovered from this genus. Full article
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