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Special Issue "Frontiers in Organic Electrosynthesis"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Electrochemistry".

Deadline for manuscript submissions: 31 March 2022.

Special Issue Editor

Prof. Dr. César Augusto Correia de Sequeira
E-Mail Website
Guest Editor

Special Issue Information

Dear Colleagues,

Organic synthesis arguably represents the most important discipline for the bottom-up assembly and late-stage diversification of molecular compounds with transformative applications to inter alia medicinal chemistry, drug development and material sciences, as well as the chemical and pharmaceutical industries. The complexity of electrochemistry and the physical properties of electrons are extraordinary and very different from other chemical reagents. Furthermore, the equipment needed to practice electrosynthesis has become readily available only since the early 1900s. These are the barriers that have inhibited the acceptance of molecular electrosynthesis until very recently. Particularly, organic electrochemistry has, in recent years, overcome some of its last limitations as a niche technique.

The pioneering contributions of Faraday’s hydrolysis of acetic acid, of Kolbe’s electrochemical decarboxylative dimerization, of Hickeling’s proposal of potential-controlled electrolysis, of Simon’s fluorination process, of Monsanto’s adiponitrile processes, of Yoshida’s concept of electroauxiliaries, of Steckan’s indirect electrolysis, of 

BASF Lysmeral process (paired electrolysis), and of the production of lead tetra-ethyl anti-knoch compounds have enabled electrosynthesis to gain significant momentum for sustainable electro-organic syntheses.

The resurgence of this strategy has received great attention  as a powerful green tool for synthesis, affording less waste production, less chemicals spent, and often fewer reaction steps than conventional methods. Functional group interconversion and C–C bond generation by imposition of a proper electrode potential is essentially what lies behind organic electrosynthesis processes. Paired electrochemical reaction, indirect electrosynthesis, electrochemical microreactors and the use of ionic liquids are some of the highlighted means that contribute to optimization of the overall process. The necessity to use specific organic solvents, combined with supporting electrolytes, is one of the main limitations to be overcome to render the electrochemical process more economically feasible when compared to non-electrochemical processes. Numerous examples from the bench scale to industrial routes, including contributions of organic electrosynthesis to green chemistry, are expected to be well covered throughout this Special Issue. Thus, we focus on the following topics:

  • Anodic functionalization of organic compounds;
  • Cathodic conversion of organic compounds;
  • Electrogenerated acids;
  • Electrogenerated bases;
  • Ionic liquids (ILs);
  • Indirect electrosynthesis;
  • Industrial electrosynthesis;
  • Dual electrocatalysis.

Prof. Dr. César Augusto Correia de Sequeira
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Organic electrosynthesis
  • Microreactors
  • Modern redox mediators
  • Organic reactions
  • Room temperature ionic liquids (RTILs)
  • Production plants design
  • Bipolar/monopolar charge flow

Published Papers

This special issue is now open for submission.
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