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Special Issue "Phytotherapeutics from Mediterranean Plants: Recent Advances"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Prof. Dr. Antonina Saija
E-Mail Website
Guest Editor
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Palatucci, Polo Universitario Annunziata, 98168 Messina, Italy
Interests: pharmacology; toxicology; natural products; phytotherapy; nanomaterials; gut; vessel endothelium
Prof. Dr. Francesco Cimino
E-Mail Website
Guest Editor
Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Palatucci, Polo Universitario Annunziata, 98168 Messina, Italy
Interests: pharmacology; toxicology; phytotherapy; vascular disease; metabolic syndrome

Special Issue Information

Dear Colleagues,

The Mediterranean region is one of the areas with the greatest biodiversity on the planet. The Mediterranean basin covers an area of ​​almost 2.6 million km2, and three continents overlook it; the presence of numerous islands as well as important mountain ranges is a geographical feature of this region. The functional element of the Mediterranean region is typically characterized by a high seasonal variability, with hot, dry summers and usually quite mild, rainy winters. The Mediterranean is also the place of origin of many civilizations, and the anthropic activities that ensued have certainly influenced the evolution of various plant species.

The combination of all these factors, geographical, geological, climatic, and anthropic, has made the Mediterranean basin a biodiversity hotspot. This enormous biodiversity means that the Mediterranean flora contains a large number of plants, native or naturalized, representing a precious source of compounds, products, or ingredients with therapeutic or health-promoting effects in humans. 

Many studies have highlighted the uses of Mediterranean plants in traditional medicine, especially against common ailments, but many new uses have been suggested and investigated against communicable and noncommunicable diseases with high global burdens, such as diabetes, cancer, and neurodegenerative diseases. One has to mention that many drugs on the market are of natural origin, as unaltered natural products or natural products modified by medicinal chemistry, and that, today, in both developing and developed countries, there is a general increase in demand for phytotherapeutics and phytopharmaceuticals.

Therefore, it is evident that research on phytotherapeutic products from Mediterranean plants may have strong health and socio-economic impacts.

This Special Issue intends to collect the state-of-the-art from original research and review articles concerning chemistry, efficacy, safety, and mechanisms of action of phytotherapeutics (both complex extracts and isolated constituents) from Mediterranean plants. To be accepted, papers must be clearly of interest to an international readership and not only to a regional audience; phytochemical investigations must be directly pertinent to the pharmacological effects of the plant-based products under study.

Prof. Dr. Antonina Saija
Prof. Dr. Francesco Cimino
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Mediterranean plants
  • phytotherapeutics
  • phytochemicals
  • traditional medicine
  • drug discovery and development
  • human health and well-being
  • noncommunicable diseases
  • communicable diseases

Published Papers

This special issue is now open for submission.
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