Dear Colleagues,

Once the human genome has largely been sequenced, one of the most important pursuits is to understand the function of the proteins it encodes. Despite the immense progress in molecular biology and genetic, only a small fraction of the proteome is understood at the biochemical level. Systems biology and proteomics strive to create detailed predictive models for molecular pathways based upon the quantitative behavior of proteins. Understanding these dynamics networks provides clues into the consequences of aberrant interactions and why they lead to diseases such as cancer, and it could be source of biomarkers or targeted proteins for novel drug design and development.

However, collecting quantitative biochemical data on protein behavior at a high scale has been dauting. Thus, methods capable of collecting quantitative data at hight-throughput level are requiered to determine differential protein profiles which could represent novel targets for new drugs or development of novel therapies.

Furthermore, the intracellular signaling pathways triggered when drugs interact with their therapeutic targets are one of the most accurate strategies to find the mechanism of action of any pharmaceutical entity. Thanks to the enormous amount of information provided by functional proteomics, the entire pharmacological profile can be established and the structure–activity relationship (SAR) of the drugs could be more precisely determined.

Hence, functional proteomics is one of the approaches which could determine targeted proteins as potential candidates for biomarkers and novel drug design.

The aim of this Special Issue is to attract contributions on all aspects of functional proteomics and pharmaceutical synthesis, with a special emphasis on recent/novel technologies and multipronged strategies that make them able to address biological problems that have not yet been faced.

Dr. Manuel Fuentes
Dr. Angela-Patricia Hernández
Guest Editors

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• proteomics
• drug discovery
• biomarkers
• drug design
• cell signaling pathway