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Smart Non-invasive Sensor Technologies for Healthcare and Biomedical Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: closed (15 August 2021) | Viewed by 16360

Special Issue Editor

University of California, San Diego, CA, USA
Interests: biosensor; non-invasive sensor; disposable sensors; biomedical device; nanomaterials; electrochemical sensor; flexible materials; Bioelectronics; water analysis; organophosphate; fungal toxins; fluiorescence

Special Issue Information

Dear Colleagues,

We cordially invite you to participate in a Special Issue on “Smart Non-Invasive Sensor Technologies for Healthcare and Biomedical Applications”. This Special Issue will focus on the state-of-the-art in non-invasive technologies for healthcare and biomedical applications and also the need for such sensors in someone’s life. Life expectation in the majority of countries has increased over the last several decades due to improvements in medication, public health, and personal and environmental hygiene. Hence, it is indispensable to develop affordable, user-friendly systems for elderly healthcare monitoring. Recently, non-invasive sensors have emerged as an alternative way to track personal healthcare and provide timely countermeasures for therapeutics. Wearable devices also provide a cost-effective solution that will allow the old age community to remain at home instead of making use of expensive healthcare services. These smart devices will also enable healthcare persons to evaluate important physiological signs in their patients in real-time. Wearable non-invasive sensors can be applied for the purpose of cancer biomarker detection, physiological biomarker analysis, on-body metabolite sensing, drug and alcohol detection, and toxic protein analysis. These devices not only avert the threat of infection, but are also easy to obtain and appropriate for long-term monitoring in an unobtrusive way. Hence, they are fit for residential and other ubiquitous monitoring applications. Such sensor devices can be developed for daily life accessories such as wrist bands, hair bands, eye glasses, lab-based gloves, bandages, textiles, tattoos, car-seats, beds, or medical treatment units.
Moreover, these smart and non-invasive sensing techniques may avoid the use of invasive methods or offer new insights into a patient’s physiological state.

Potential topics include, but are not limited to:

  • development, fabrication, and characterization of smart nanomaterials or nanostructures;
  • nano-sensors and nanodevices;
  • synthesis of nanowires, nanodrods, nanoclusters, and nanostructures;
  • optoelectronic materials and nanodevices using hetero/nanostructures;
  • nanocytotoxicity and nanomedicine using nanomaterials;
  • nanodevices as a carrier in drug transport;
  • nanomaterials for biomedicine and healthcare;
  • life science applications of non-invasive sensors;
  • wearable sensors and biosensors for biomedicine and healthcare;
  • nanoscale biosensors;
  • nanodevices with application in robotics;
  • employment of different transducers for non-invasive sensor devices;
  • light-emitting devices and optical modulators;
  • integrated waveguide sensing;
  • microneedle sensors for wearables;
  • transdermal non/minimally invasive sensors;
  • textile sensors;
  • bandage- and glove-based sensors;
  • potentiometric and amperometric sensors;
  • supercapacitors for sensor applications;
  • disposable sensor strips for healthcare;
  • screen-printed electrodes; and

lithographical devices for non-invasive sensing.

Dr. Rupesh K. Mishra
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • non-invasive
  • minimally invasive
  • wearable sensors
  • biomedicine
  • healthcare

Published Papers (2 papers)

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Research

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13 pages, 2549 KiB  
Article
Micro-Raman Characterization of Structural Features of High-k Stack Layer of SOI Nanowire Chip, Designed to Detect Circular RNA Associated with the Development of Glioma
by Yuri D. Ivanov, Kristina A. Malsagova, Vladimir P. Popov, Igor N. Kupriyanov, Tatyana O. Pleshakova, Rafael A. Galiullin, Vadim S. Ziborov, Alexander Yu. Dolgoborodov, Oleg F. Petrov, Andrey V. Miakonkikh, Konstantin V. Rudenko, Alexander V. Glukhov, Alexander Yu. Smirnov, Dmitry Yu. Usachev, Olga A. Gadzhieva, Boris A. Bashiryan, Vadim N. Shimansky, Dmitry V. Enikeev, Natalia V. Potoldykova and Alexander I. Archakov
Molecules 2021, 26(12), 3715; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26123715 - 18 Jun 2021
Cited by 6 | Viewed by 2122
Abstract
The application of micro-Raman spectroscopy was used for characterization of structural features of the high-k stack (h-k) layer of “silicon-on-insulator” (SOI) nanowire (NW) chip (h-k-SOI-NW chip), including Al2O3 and HfO2 in various combinations after heat treatment from 425 to [...] Read more.
The application of micro-Raman spectroscopy was used for characterization of structural features of the high-k stack (h-k) layer of “silicon-on-insulator” (SOI) nanowire (NW) chip (h-k-SOI-NW chip), including Al2O3 and HfO2 in various combinations after heat treatment from 425 to 1000 °C. After that, the NW structures h-k-SOI-NW chip was created using gas plasma etching optical lithography. The stability of the signals from the monocrine phase of HfO2 was shown. Significant differences were found in the elastic stresses of the silicon layers for very thick (>200 nm) Al2O3 layers. In the UV spectra of SOI layers of a silicon substrate with HfO2, shoulders in the Raman spectrum were observed at 480–490 cm−1 of single-phonon scattering. The h-k-SOI-NW chip created in this way has been used for the detection of DNA-oligonucleotide sequences (oDNA), that became a synthetic analog of circular RNA–circ-SHKBP1 associated with the development of glioma at a concentration of 1.1 × 10−16 M. The possibility of using such h-k-SOI NW chips for the detection of circ-SHKBP1 in blood plasma of patients diagnosed with neoplasm of uncertain nature of the brain and central nervous system was shown. Full article
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Review

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32 pages, 3050 KiB  
Review
Wearable Biosensors: An Alternative and Practical Approach in Healthcare and Disease Monitoring
by Atul Sharma, Mihaela Badea, Swapnil Tiwari and Jean Louis Marty
Molecules 2021, 26(3), 748; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26030748 - 01 Feb 2021
Cited by 118 | Viewed by 13480
Abstract
With the increasing prevalence of growing population, aging and chronic diseases continuously rising healthcare costs, the healthcare system is undergoing a vital transformation from the traditional hospital-centered system to an individual-centered system. Since the 20th century, wearable sensors are becoming widespread in healthcare [...] Read more.
With the increasing prevalence of growing population, aging and chronic diseases continuously rising healthcare costs, the healthcare system is undergoing a vital transformation from the traditional hospital-centered system to an individual-centered system. Since the 20th century, wearable sensors are becoming widespread in healthcare and biomedical monitoring systems, empowering continuous measurement of critical biomarkers for monitoring of the diseased condition and health, medical diagnostics and evaluation in biological fluids like saliva, blood, and sweat. Over the past few decades, the developments have been focused on electrochemical and optical biosensors, along with advances with the non-invasive monitoring of biomarkers, bacteria and hormones, etc. Wearable devices have evolved gradually with a mix of multiplexed biosensing, microfluidic sampling and transport systems integrated with flexible materials and body attachments for improved wearability and simplicity. These wearables hold promise and are capable of a higher understanding of the correlations between analyte concentrations within the blood or non-invasive biofluids and feedback to the patient, which is significantly important in timely diagnosis, treatment, and control of medical conditions. However, cohort validation studies and performance evaluation of wearable biosensors are needed to underpin their clinical acceptance. In the present review, we discuss the importance, features, types of wearables, challenges and applications of wearable devices for biological fluids for the prevention of diseased conditions and real-time monitoring of human health. Herein, we summarize the various wearable devices that are developed for healthcare monitoring and their future potential has been discussed in detail. Full article
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