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Special Issue "Spatiotemporal Regulation of Signaling by Intracellular Trafficking"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: closed (31 December 2021).

Special Issue Editor

Dr. Alejandra Tomas
E-Mail Website
Guest Editor
Section of Cell Biology and Functional Genomics, Division of Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, W12 0NN, UK
Interests: beta cell; incretin signaling; insulin secretion; type 2 diabetes; membrane trafficking; endocytosis

Special Issue Information

Dear Colleagues,

Intracellular trafficking of proteins and lipids are highly regulated processes that require the coordination of various signaling mediators in order to control cargo sorting and processing. Additionally, recent work has shown that the various vesicular and nonvesicular trafficking pathways, including the biosynthetic and exosomal secretory pathways, endocytic trafficking, segregation to lipid nanodomains, lysosomal targeting, and lipid transport at membrane contact sites regulate various signaling pathways to determine cellular function. Despite recent advances, the precise regulation of signaling outputs and integration of multiple signaling events by intracellular trafficking is not yet well understood. In this Special Issue, we aim to highlight recent developments in the field, including new methodology and conceptual advances, as well as to create a forum for discussion of the current challenges and future goals in our understanding of the spatiotemporal control of cell signaling processes.

Dr. Alejandra Tomas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Intracellular trafficking
  • Spatiotemporal control of signaling
  • Signal integration
  • Lipid nanodomains
  • Cellular function
  • Protein and lipid transport

Published Papers

There is no accepted submissions to this special issue at this moment.
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