Dear Colleagues,

Though absent in nature, the sulfonamide motif has emerged as an essential unit in numerous synthesized non-cyclic and cyclic architectures possessing pharmaceutical impact. So far, they have been included in more than 100 FDA-approved drugs and potential drug candidates. Whereas the preparation of non-cyclic sulfonamides with simple synthetic methodologies has been achieved and it is possible to obtain the desired substitution patterns in target structures, cyclic structures containing the sulfonamide motif are still challenging to produce. On the other hand, sulfonamides as carboxyl group bioisosteres can rapidly form in chemical reactions carried out during medicinal chemistry or drug discovery research. In contrast, their bioisosteres including sulfonimidamides or sulfonimides are less investigated in synthetic or medicinal chemistry studies. Indeed, their synthesis is more challenging, since it requires multistep synthetic procedures.

This Special Issue will publish works describing synthetic routes for the production of novel sulfonamide derivatives and investigating their bioactivity, e.g., their anti-cancer effects. The submission of research articles is mainly expected, as well as access towards cytotoxic chemical libraries including bioactive compounds with novel substitution patterns. Because of the recent developments in drug design and synthetic chemistry, review articles on these topics will also be considered.

Dr. Gabor J. Szebeni
Dr. Ivan Kanizsai
Guest Editors

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• sulfuric acid
• sulfonamides
• sulfonimidamides
• bioactive compounds