Dear Colleagues,

During recent decades, research on natural antioxidants (NAs) has been increasingly noteworthy due to the bioactivity of such antioxidants in promoting health and disease prevention. In particular, it has been demonstrated that natural antioxidants exert beneficial effects in different chronic degenerative diseases, such as cancer, diabetes, and cardiovascular and neurodegenerative diseases. The burden of chronic diseases is rapidly increasing worldwide, and it represents a major challenge for health systems and economic and social development. Furthermore, natural antioxidants are considered safer and more acceptable compared to synthetic antioxidants.

This Special Issue focuses on natural antioxidants modulating oxidative stress. This Special Issue will bring together articles that address the role of natural antioxidants in physiological and pathological conditions, including, but not limited to, cardiovascular diseases, cancer, aging, the alleviation of pain or inflammation, immunomodulation, promotion of neuroprotection, improvement of physical performance, and tissue regeneration. We welcome manuscripts that clarify the mechanisms of action and signaling pathways of NAs linked to redox balance that may be involved in physiological changes and the improvement of clinical outcomes.

Original research and review articles are welcome.

Potential topics include, but are not limited to, the following:

• Molecular and cellular mechanisms of natural antioxidant compounds in controlling oxidative stress impact on health and disease;
• Natural antioxidant compounds as strategies to prevent/treat cellular damage underlying oxidative stress;
• Recent discoveries in animal models to understand the role of natural antioxidant compounds in human disorders connected to excessive oxidative stress;
• Impact of natural antioxidant compounds combined with pharmacological and non-pharmacological therapies to improve oxidative stress in multiple tissue disorders.

Prof. Dr. Daniela Beghelli
Dr. Cristina Angeloni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• natural antioxidants
• aging
• neuroprotection
• neurodegeneration
• immunomodulation
• cardiovascular diseases
• oxidative stress
• cancer
• inflammation