New Strategies for Anticancer and Antimicrobial Studies Based on Emerging Nanostructures

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (20 December 2021) | Viewed by 2711

Special Issue Editor


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Guest Editor
1. Zoology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
2. Chair for DNA Research, College of Science, Zoology Department, King Saud University, Riyadh 11451, Saudi Arabia
Interests: inorganic; organic-based nanostructures; nanomaterials; nanostructure-based cancer formulations; nanostructures as antimicrobial agents; biomedical nanodevices; drug delivery; functional nanostructures; DNA binding studies
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Special Issue Information

Dear Colleagues,

The present Special Issue aims to present new strategies for developing nanostructure-based formulations to enhance their therapeutic use, minimize the instrumental analysis cost for various types of cancers (chemotherapy, radiotherapy, immunotherapy, surgery, etc.), and aid in their applications as antimicrobial agents.

We aim to encompasses a variety of nanostructure material applications in all areas of science (chemistry, physics, biology, medical, engineering, agriculture, etc.), including the use of quantum dots, nanoparticles, and a range of nanostructures to control various types of cancer, microbes, infectious diseases, drug delivery, and DNA binding, as well as the application of physico, chemico, and biochemical sensors.

Prof. Rizwan Wahab
Guest Editor

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Keywords

  • nanostructured materials
  • cancer nanotechnology
  • nanostructures for microbes
  • alternative therapies for cancers
  • nanostructures for drug delivery
  • smart nanosensing formulations and devices for cancers
  • biomedical applications of nanostructures
  • new strategies for cancer targeting molecules

Published Papers (1 paper)

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Research

18 pages, 6294 KiB  
Article
Reactive Oxygen Species-Mediated Cytotoxicity in Liver Carcinoma Cells Induced by Silver Nanoparticles Biosynthesized Using Schinus molle Extract
by Waleed Ali Hailan, Khalid Mashay Al-Anazi, Mohammad Abul Farah, Mohammad Ajmal Ali, Ahmed Ali Al-Kawmani and Faisal Mohammed Abou-Tarboush
Nanomaterials 2022, 12(1), 161; https://0-doi-org.brum.beds.ac.uk/10.3390/nano12010161 - 03 Jan 2022
Cited by 15 | Viewed by 2255
Abstract
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is ranked as the third most common cause of cancer-related mortality worldwide. Schinus molle (S. mole) L. is an important medicinal plant that contains many bioactive compounds with pharmacological properties. [...] Read more.
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is ranked as the third most common cause of cancer-related mortality worldwide. Schinus molle (S. mole) L. is an important medicinal plant that contains many bioactive compounds with pharmacological properties. The role of S. molle leaf extract in the biosynthesis of silver nanoparticles (AgNPs) was determined. The biosynthesized AgNPs were thoroughly characterized by UV–vis spectrophotometry, transmission electron microscopy (TEM), X-ray diffraction (XRD), and dynamic light scattering (DLS) techniques. Furthermore, the cytotoxic effect of the biosynthesized AgNPs using S. molle (SMAgNPs) against HepG2 liver cancer cells was investigated. Reactive oxygen species generation, apoptosis induction, DNA damage, and autophagy activity were analyzed. The results clearly showed that the biosynthesized silver nanoparticles inhibited the proliferation of HepG2 by significantly (p < 0.05) inducing oxidative stress, cytotoxicity, DNA damage, apoptosis, and autophagy in a dose- and time-dependent manner. These findings may encourage integrating the potential of natural products and the efficiency of silver nanoparticles for the fabrication of safe, environmentally friendly, and effective anticancer agents. Full article
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