Investigation of Engineered Nanoparticle Bioactivity and Their Toxicology

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 3048

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Vinča Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, Mike Petrovića Alasa 12-14, Vinča, 11351 Belgrade, Serbia
Interests: carbon quantum dots; carbon nanomaterials; antimicrobial and antiviral plastics; photodynamic therapy of cancer and microbes
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Special Issue Information

Dear Colleagues,

The bioactivity and toxicity of different nanoparticles attract the attention of many researchers due to their significance in biomedicine. According to their activity and toxicity, nanoparticles can be applied in various fields and forms such as films, gels, fibres or foams or in combination with hydrogels, ceramics, metals and polymers. Their unique chemical, mechanical, optical and biological properties enable their use as a safe material in physiological environments. The main role of biomaterials during interaction with biological systems is to evaluate, treat, heal or replace any tissue or organ. Therefore, it is very important to study the properties of nanoparticles themselves as well as the mechanism of their interaction with biological systems.

In this issue, different aspects of nanoparticles acting mainly directed to tumors and microbials will be discussed. The main topics include the following:

  • Bioactivities and nanotoxicity of antitumor nanoparticles
  • Bioactivities and nanotoxicity of antimicrobial nanoparticles;
  • Bioactivities and nanotoxicity of antiviral nanoparticles;
  • Mechanisms of interactions between nanoparticles and cells.

The issue will be a valuable resource for a broad readership in this time of epidemy in various subfields of medicine, natural and social sciences. It will be a collection of research and review papers discussing the most recent progress in these areas.

Dr. Zoran M. Marković
Guest Editor

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Keywords

  • antitumor nanoparticles
  • antimicrobial nanoparticles
  • antiviral nanoparticles

Published Papers (2 papers)

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17 pages, 2787 KiB  
Article
Highly Efficient Antibacterial Polymer Composites Based on Hydrophobic Riboflavin Carbon Polymerized Dots
by Zoran M. Marković, Mária Kováčová, Sanja R. Jeremić, Štefan Nagy, Dušan D. Milivojević, Pavel Kubat, Angela Kleinová, Milica D. Budimir, Marija M. Mojsin, Milena J. Stevanović, Adriana Annušová, Zdeno Špitalský and Biljana M. Todorović Marković
Nanomaterials 2022, 12(22), 4070; https://0-doi-org.brum.beds.ac.uk/10.3390/nano12224070 - 18 Nov 2022
Cited by 14 | Viewed by 2038
Abstract
Development of new types of antimicrobial coatings is of utmost importance due to increasing problems with pathogen transmission from various infectious surfaces to human beings. In this study, new types of highly potent antimicrobial polyurethane composite films encapsulated by hydrophobic riboflavin-based carbon polymer [...] Read more.
Development of new types of antimicrobial coatings is of utmost importance due to increasing problems with pathogen transmission from various infectious surfaces to human beings. In this study, new types of highly potent antimicrobial polyurethane composite films encapsulated by hydrophobic riboflavin-based carbon polymer dots are presented. Detailed structural, optical, antimicrobial, and cytotoxic investigations of these composites were conducted. Low-power blue light triggered the composites to eradicate Escherichia coli in 30 min, whereas the same effect toward Staphylococcus aureus was reached after 60 min. These composites also show low toxicity against MRC-5 cells. In this way, RF-CPD composites can be used for sterilization of highly touched objects in the healthcare industry. Full article
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19 pages, 2988 KiB  
Article
Silver Nanoparticles Containing Fucoidan Synthesized by Green Method Have Anti-Trypanosoma cruzi Activity
by Adriana Oliveira Souza, Johny Wysllas de Freitas Oliveira, Claudia Jéssica Gonsalves Moreno, Mayra Jane Campos de Medeiros, Marília Medeiros Fernandes-Negreiros, Flavia Roberta Monteiro Souza, Daniel Lima Pontes, Marcelo Sousa Silva and Hugo Alexandre Oliveira Rocha
Nanomaterials 2022, 12(12), 2059; https://0-doi-org.brum.beds.ac.uk/10.3390/nano12122059 - 15 Jun 2022
Cited by 6 | Viewed by 1683
Abstract
The brown seaweed Spatoglossum schröederi synthesizes three bioactive fucoidans, the most abundant of which is fucan A. This fucoidan was extracted and its identity was confirmed by chemical analysis, Fourier-transform infrared spectroscopy (FTIR), and agarose gel electrophoresis. Thereafter, silver nanoparticles containing fucan A [...] Read more.
The brown seaweed Spatoglossum schröederi synthesizes three bioactive fucoidans, the most abundant of which is fucan A. This fucoidan was extracted and its identity was confirmed by chemical analysis, Fourier-transform infrared spectroscopy (FTIR), and agarose gel electrophoresis. Thereafter, silver nanoparticles containing fucan A (AgFuc) were produced using an environmentally friendly synthesis method. AgFuc synthesis was analyzed via UV–vis spectroscopy and FTIR, which confirmed the presence of both silver and fucan A in the AgFuc product. Dynamic light scattering (DLS), X-ray diffraction, scanning electron microscopy, and atomic force microscopy revealed that the AgFuc particles were ~180.0 nm in size and spherical in shape. DLS further demonstrated that AgFuc was stable for five months. Coupled plasma optical emission spectrometry showed that the AgFuc particles contained 5% silver and 95% sugar. AgFuc was shown to be more effective in inhibiting the ability of parasites to reduce MTT than fucan A or silver, regardless of treatment time. In addition, AgFuc induced the death of ~60% of parasites by necrosis and ~17% by apoptosis. Therefore, AgFuc induces damage to the parasites’ mitochondria, which suggests that it is an anti-Trypanosoma cruzi agent. This is the first study to analyze silver nanoparticles containing fucan as an anti-Trypanosoma cruzi agent. Our data indicate that AgFuc nanoparticles have potential therapeutic applications, which should be determined via preclinical in vitro and in vivo studies. Full article
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