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Nanomaterials
Special Issues
Metal-Based Nanoparticles as Antimicrobial Agents: Trends and Prospects
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Metal-Based Nanoparticles as Antimicrobial Agents: Trends and Prospects

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Synthesis, Interfaces and Nanostructures".

Deadline for manuscript submissions: closed (15 August 2022) | Viewed by 3130

Special Issue Editor

Prof. Dr. Junwei Ye

E-Mail Website
Guest Editor
State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian, China
Interests: antibacterial materials; boron-based functional materials; metal-organic frameworks; chemical resources

Special Issue Information

Dear Colleagues,

Bacteria are ubiquitous, living in every possible habitat on the planet. However, several species of bacteria are pathogenic and cause infectious diseases, including cholera, syphilis, anthrax, leprosy, and bubonic plague. Antibiotics are used to treat bacterial infections, making antibiotic resistance a growing problem. Thus, research to understand and fight a wide range of pathogenic bacterial infections must be pursued. Metal-based nanomaterials and its composites has attracted extensive interest as an appealing approach to extirpate bacterial pathogenic strains.

The Special Issue invites contributions from the following categories of metal-based antibacterial nanomaterials: (i) Characterization of the metal-based nanomaterials and its composites include, but are not limited to, metal nanoparticles, metal oxides, and metal-organic frameworks and their composites; (ii) Antimicrobial surfaces and coatings; (iii) Nanomedicine and nanotechnology with applications in drug delivery, imaging, theranostics, and for therapy of infectious diseases; (iv) Skin regeneration and wound healing; (v) Devices for healthcare applications.

We await your contribution to the topics above or other relevant topics with great interest.

Prof. Dr. Junwei Ye
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metal-based nanomaterials
  • antimicrobial materials
  • antibacterial surfaces
  • drug delivery
  • infectious diseases
  • wound healing
  • antibacterial devices
 

Published Papers (2 papers)

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Research

9 pages, 1689 KiB  
Communication
Development of Direct Immobilization Technique of Ag Nanoparticles on Resin Substrates Imparting High Antibacterial and Antiviral Activities
by Satoshi Seino, Yuji Ohkubo, Tomonari Magara, Hiroki Enomoto, Eri Nakajima, Tomoki Nishida, Yasuo Imoto and Takashi Nakagawa
Nanomaterials 2022, 12(17), 3046; https://0-doi-org.brum.beds.ac.uk/10.3390/nano12173046 - 02 Sep 2022
Cited by 3 | Viewed by 1099
Abstract
A new method has been developed to impart the antimicrobial activity of silver nanoparticles to resin substrates. A resin substrate immersed in an aqueous solution of silver nitrate was irradiated with gamma ray or high energy electron beams. Silver nanoparticles were successfully immobilized [...] Read more.
A new method has been developed to impart the antimicrobial activity of silver nanoparticles to resin substrates. A resin substrate immersed in an aqueous solution of silver nitrate was irradiated with gamma ray or high energy electron beams. Silver nanoparticles were successfully immobilized on the resin surface directly by chemical reactions induced by ionizing radiation. It was experimentally confirmed that various resin materials, such as acrylonitrile-butadiene-styrene, polyethylene, polypropylene, polyvinyl chloride, and polycarbonate, were applicable for this process. The effects of gamma ray or electron beam irradiation on resin substrates were almost negligible since the irradiation dose was equal or less than that used for sterilization. Despite the small amount of Ag loadings, the obtained samples showed high antibacterial and antiviral activities. Full article
(This article belongs to the Special Issue Metal-Based Nanoparticles as Antimicrobial Agents: Trends and Prospects)
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Graphical abstract

25 pages, 10890 KiB  
Article
Ciprofloxacin-Loaded Silver Nanoparticles as Potent Nano-Antibiotics against Resistant Pathogenic Bacteria
by Duaa R. Ibraheem, Nehia N. Hussein, Ghassan M. Sulaiman, Hamdoon A. Mohammed, Riaz A. Khan and Osamah Al Rugaie
Nanomaterials 2022, 12(16), 2808; https://0-doi-org.brum.beds.ac.uk/10.3390/nano12162808 - 16 Aug 2022
Cited by 38 | Viewed by 2963
Abstract
Silver nanoparticles (AgNPs) have demonstrated numerous physicochemical, biological, and functional properties suitable for biomedical applications, including antibacterial and drug carrier properties. In the present study, the antibiotic, ciprofloxacin (CIP), was loaded onto AgNPs, which were synthesized via the chemical reduction method, thereby enhancing [...] Read more.
Silver nanoparticles (AgNPs) have demonstrated numerous physicochemical, biological, and functional properties suitable for biomedical applications, including antibacterial and drug carrier properties. In the present study, the antibiotic, ciprofloxacin (CIP), was loaded onto AgNPs, which were synthesized via the chemical reduction method, thereby enhancing CIP’s antibacterial activity against Gram-negative (Acinetobacter baumannii and Serratia marcescens) and Gram-positive (Staphylococcus aureus) bacterial strains. Polyethylene glycol–400 (PEG) was used to prepare an AgNPs-PEG conjugate with enhanced stability and to act as the linker between CIP and AgNPs, to produce the novel nanocomposite, AgNPs-PEG-CIP. The prepared AgNPs and their conjugates were characterized by ultraviolet-visible spectrophotometry, Fourier-transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy with energy-dispersive X-ray spectroscopy, transmission electron microscopy, zeta potential analysis, and dynamic light scattering techniques. The inhibitory activity of AgNPs and their conjugates on the growths of pathogenic bacteria was assessed using the well-diffusion method. The results showed the enhanced antibacterial effects of AgNPs-CIP compared to CIP alone. The AgNPs-PEG-CIP nanocomposite showed excellent inhibitory effects against bacterial isolates, with its inhibition zones diameters reaching 39, 36, and 40 mm in S. aureus, A. baumannii, and S. marcescens, respectively. The minimum inhibitory concentration and minimum bactericidal concentration of fogNPs and their conjugates and their antibiofilm effects were also determined. The antioxidant potentials of AgNPs and their conjugates, tested via their 1,1-diphenyl-2-picryl-hydrazyl (DPPH) scavenging ability, showed that the activity increased with increasing AgNPs concentration and the addition of the PEG and/or CIP. Overall, according to the results obtained in the present study, the new nanocomposite, AgNPs-PEG-CIP, showed the highest antibacterial, antibiofilm, and antioxidant activity against the pathogenic bacteria tested, compared to CIP alone. The preparation has high clinical potential for prospective use as an antibacterial agent. Full article
(This article belongs to the Special Issue Metal-Based Nanoparticles as Antimicrobial Agents: Trends and Prospects)
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