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Nanomaterials
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Nanomaterials-Cell Interaction: Cytotoxicity/Therapeutic Potential
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Nanomaterials-Cell Interaction: Cytotoxicity/Therapeutic Potential

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (22 February 2022) | Viewed by 11139

Special Issue Editor

Dr. Marta Grodzik

E-Mail Website
Guest Editor
Department of Nanobiotechnology, Institute of Biology, Warsaw University of Life Sciences, Warsaw, Poland
Interests: nanobiotechnology; nanomaterials; nanomedicine; graphene; diamond nanoparticle; noble nanoparticle; drug delivery; brain cancer; anticancer agents

Special Issue Information

Dear Colleagues,

This Special Issue deals with all aspects of cytotoxicity and the therapeutic potential of nanomaterials (NM) at the cellular level. Due to their many unique physicochemical properties, NM have significant therapeutic importance for treating, e.g., cancer, cardiovascular diseases, orthopedic diseases or bacterial and viral infections, as active factors, cell matrices or drug transporters. However, NM may induce cytotoxic effects such as overproduction of free radicals or DNA damage. The greatest challenge for NM is therefore to refine their concentrations, functional group modifications or sizes for specific medical applications to enhance their selectivity. Testing the cytotoxicity and functional activity of several different cell lines is the first step to verify the clinical use of NM.

This Special Issue focuses on the design and characterization of NM and their future clinical applications, with emphasis on the current challenges and their future direction.

It is my pleasure to invite you to submit a manuscript for this Special Issue. Full papers, communications, and reviews are all welcome.

Dr. Marta Grodzik
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nanoparticles
  • Nanolayers
  • Cytotoxicity
  • Cellular interaction
  • Cell uptake
  • Cellular mechanisms
  • Signaling pathways
  • Apoptosis
  • Necrosis
  • Gene regulation
  • Oxidative stress

Published Papers (4 papers)

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Research

13 pages, 1661 KiB  
Article
Polysaccharide Nanoparticles from Isatis indigotica Fort. Root Decoction: Diversity, Cytotoxicity, and Antiviral Activity
by Guanzhen Gao, Chuanqi He, Huiqin Wang, Jingke Guo, Lijing Ke, Jianwu Zhou, Pik Han Chong and Pingfan Rao
Nanomaterials 2022, 12(1), 30; https://0-doi-org.brum.beds.ac.uk/10.3390/nano12010030 - 23 Dec 2021
Cited by 5 | Viewed by 2739
Abstract
It has been revealed that numerous nanoparticles are formed during the boiling preparation of traditional Chinese medical decoctions and culinary soups. They may possess physiological effects different from those of constituent components and are worth paying attention to but are barely noticed and [...] Read more.
It has been revealed that numerous nanoparticles are formed during the boiling preparation of traditional Chinese medical decoctions and culinary soups. They may possess physiological effects different from those of constituent components and are worth paying attention to but are barely noticed and investigated as of yet. In this study, six groups of nanoparticles, whose size ranged from 57 to 300 nm, were successfully isolated from the decoction of Isatis indigotica Fort. root, according to their particle size by the means of size-exclusive chromatography. All of the obtained nanoparticles have a high content of polysaccharides, which distinguishes them from the disclosed BLG protein nanoparticles. They also have high similarities in other compositions, surface charge, and stimuli responses. However, four out of these six nanoparticles (F2, F3, F4, and F5) exhibited significant antiviral activity against influenza virus H1N1, and their antiviral activities and cytotoxicity towards MDCK cells varied with their sizes. It suggested that the antiviral efficacy of BLG decoction could also be from its nanoparticles besides its well-known antiviral phytochemicals. It also implied that the biological effects of these polysaccharide nanoparticles, including cytotoxicity and antiviral activity, may be correlative with the physicochemical properties, especially the particle size. Full article
(This article belongs to the Special Issue Nanomaterials-Cell Interaction: Cytotoxicity/Therapeutic Potential)
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9 pages, 1134 KiB  
Article
Impact of Carbon Fluoroxide Nanoparticles on Cell Proliferation
by Alain Géloën, Gauhar Mussabek, Alexander Kharin, Tetiana Serdiuk, Sergei A. Alekseev and Vladimir Lysenko
Nanomaterials 2021, 11(12), 3168; https://0-doi-org.brum.beds.ac.uk/10.3390/nano11123168 - 23 Nov 2021
Cited by 3 | Viewed by 1312
Abstract
Cytotoxicity of fluorescent carbon fluoroxide (CFO) nanoparticles (NPs) was studied in a label-free manner on several cancer and non-cancer cell lines. A direct cytotoxic effect of the CFO NPs was clearly observed by a suppression of cell proliferation. The real-time measurement of cell [...] Read more.
Cytotoxicity of fluorescent carbon fluoroxide (CFO) nanoparticles (NPs) was studied in a label-free manner on several cancer and non-cancer cell lines. A direct cytotoxic effect of the CFO NPs was clearly observed by a suppression of cell proliferation. The real-time measurement of cell activities allowed to quantify the impact of the uptaken NPs on cell proliferation and after washout of the NPs from the cell culture medium. The results show more toxic effects of the CFO NPs on cancer than on non-cancer cell lines. The notion of NPs biocompatibility must be related to a maximum concentration value of the NPs acceptable for a given cell type. Furthermore, the cytotoxicity effects of NPs should be studied not only during their direct exposure to cells but also after their washout from the culture medium. Full article
(This article belongs to the Special Issue Nanomaterials-Cell Interaction: Cytotoxicity/Therapeutic Potential)
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19 pages, 7070 KiB  
Article
Cellular SPION Uptake and Toxicity in Various Head and Neck Cancer Cell Lines
by Matthias Balk, Theresa Haus, Julia Band, Harald Unterweger, Eveline Schreiber, Ralf P. Friedrich, Christoph Alexiou and Antoniu-Oreste Gostian
Nanomaterials 2021, 11(3), 726; https://0-doi-org.brum.beds.ac.uk/10.3390/nano11030726 - 13 Mar 2021
Cited by 14 | Viewed by 2663
Abstract
Superparamagnetic iron oxide nanoparticles (SPIONs) feature distinct magnetic properties that make them useful and effective tools for various diagnostic, therapeutic and theranostic applications. In particular, their use in magnetic drug targeting (MDT) promises to be an effective approach for the treatment of various [...] Read more.
Superparamagnetic iron oxide nanoparticles (SPIONs) feature distinct magnetic properties that make them useful and effective tools for various diagnostic, therapeutic and theranostic applications. In particular, their use in magnetic drug targeting (MDT) promises to be an effective approach for the treatment of various diseases such as cancer. At the cellular level, SPION uptake, along with SPION-mediated toxicity, represents the most important prerequisite for successful application. Thus, the present study determines SPION uptake, toxicity and biocompatibility in human head and neck tumor cell lines of the tongue, pharynx and salivary gland. Using magnetic susceptibility measurements, microscopy, atomic emission spectroscopy, flow cytometry, and plasma coagulation, we analyzed the magnetic properties, cellular uptake and biocompatibility of two different SPION types in the presence and absence of external magnetic fields. Incubation of cells with lauric acid and human serum albumin-coated nanoparticles (SPIONLA-HSA) resulted in substantial particle uptake with low cytotoxicity. In contrast, uptake of lauric acid-coated nanoparticles (SPIONLA) was substantially increased but accompanied by higher toxicity. The presence of an external magnetic field significantly increased cellular uptake of both particles, although cytotoxicity was not significantly increased in any of the cell lines. SPIONs coated with lauric acid and/or human serum albumin show different patterns of uptake and toxicity in response to an external magnetic field. Consequently, the results indicate the potential use of SPIONs as vehicles for MDT in head and neck cancer. Full article
(This article belongs to the Special Issue Nanomaterials-Cell Interaction: Cytotoxicity/Therapeutic Potential)
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22 pages, 6992 KiB  
Article
Green Synthesis of Silver Nanoparticles Using Annona muricata Extract as an Inducer of Apoptosis in Cancer Cells and Inhibitor for NLRP3 Inflammasome via Enhanced Autophagy
by Majid S. Jabir, Yasmin M. Saleh, Ghassan M. Sulaiman, Nahi Y. Yaseen, Usama I. Sahib, Yaser Hassan Dewir, Mona S. Alwahibi and Dina A. Soliman
Nanomaterials 2021, 11(2), 384; https://0-doi-org.brum.beds.ac.uk/10.3390/nano11020384 - 03 Feb 2021
Cited by 103 | Viewed by 5558
Abstract
Annona muricata is one of the most important traditional medicinal plants which contains numerous chemicals that exhibit various pharmacological properties. In this study, silver nanoparticles were prepared using A. muricata peel extract as a reducing agent and the effect was enhanced through A. [...] Read more.
Annona muricata is one of the most important traditional medicinal plants which contains numerous chemicals that exhibit various pharmacological properties. In this study, silver nanoparticles were prepared using A. muricata peel extract as a reducing agent and the effect was enhanced through A. muricata like pharmaceutical activity. AgNPs formation was confirmed by color changes, UV-visible spectroscopy, SEM, DLS, and XRD. The anti-proliferative activity of AgNPs against THP-1, AMJ-13, and HBL cell lines was studied. Apoptotic markers were tested using AO/EtBr staining assay, cell cycle phases using flowcytometry, and the expression of P53. Autophagy takes an essential part in controlling inflammasome activation by primary bone marrow-derived macrophages (BMDMs). We report novel functions for AgNPs-affected autophagy, represented by the control of the release of IL-1β, caspase-1, adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC), and NLRP3 in BMDMs following treatment with LPS+ATP. The current study revealed that the AgNPs inhibited THP-1 and AMJ-13 cell proliferation. Meanwhile, the AgNPs significantly increased autophagy and reduced IL-1b and NLRP3 levels in both in vivo and in vitro models. The secretion of IL-1β was reduced whereas the degradation of NLRP3 inflammasome was enhanced. These findings propose that AgNPs apply an anti-proliferative activity against THP-1 and AMJ-13 cells through the stimulation of apoptosis via mitochondrial damage and induction of p53 protein pathway. In addition, AgNP-induced autophagy reduced the levels of IL-1β and NLRP3 inflammasome activation. This indicated that the AgNPs augment autophagy controlled by the IL-1β pathway via two different novel mechanisms. The first one is regulating activation of the IL-1 β, caspase-1, and ASC, while the second is NLRP3 targeting for lysosomal degradation. Overall, this study suggests that AgNPs could be a potent therapy for various types of cancer and an alternative treatment for preventing inflammation via enhancing autophagy. Full article
(This article belongs to the Special Issue Nanomaterials-Cell Interaction: Cytotoxicity/Therapeutic Potential)
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