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Nanomaterials
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Nanoparticle-Protein Corona: A Source of Novel Molecular Targets
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Nanoparticle-Protein Corona: A Source of Novel Molecular Targets

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 9596

Special Issue Editor

Dr. Cristina Núñez González

E-Mail Website
Guest Editor
Research Unit, Oncology Division, Hospital Universitario Lucus Augusti (HULA), 27003 Lugo, Spain
Interests: circulating biomarkers; proteomics; nanomaterials; oncology; diagnosis; prognosis; prediction; therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

When nanoparticles are introduced into a biological fluid (serum, urine, cell and tissue lysates), proteins tend to associate on the particle surface to form a protein layer termed the "protein corona" (PC). Many factors affect the PC signature, these include characteristics of the NP (i.e. size, charge, and surface functionalization), the composition of the core NPs, characteristics of the protein (i.e. molecular weight, isoelectric points, structure and folding), characteristics of the interaction (i.e. time, temperature, concentration) and the type of biological sample.       

Importantly, PC composition vary with individual disease states (e.g. diabetes, rheumatism, cancer, hyperfibrinogenaemia, hypercholesterolemia, obesity, haemodialysis,  haemophilia and pregnancy), as well as specific disease conditions (e.g. cancer stage or grade and tumor heterogeneity). Hence, NP surfaces provide a unique platform to sequester, enrich, and identify novel molecular targets with potential diagnostic and therapeutic applicability.

I kindly invite you to make a contribution to the Special Issue of Nanomaterials entitled “Nanoparticle-protein corona: a source of novel molecular targets”. This Special Issue of Nanomaterials aims at collecting reviews and recent papers on the most recent development in the analysis of the nanoparticle-protein corona for the identification of molecular targets of different diseases to improve their diagnosis and treatment.

Dr. Cristina Núñez González
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticle
  • protein corona
  • dynamic light scattering (DLS)
  • transmission electron microscopy (TEM)
  • atomic force microscopy (AFM)
  • sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE)
  • disease
  • molecular target
  • diagnostic
  • therapeutic

Published Papers (3 papers)

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Research

19 pages, 2853 KiB  
Article
Nanoparticles Surface Chemistry Influence on Protein Corona Composition and Inflammatory Responses
by Laura E. González-García, Melanie N. MacGregor, Rahul M. Visalakshan, Artur Lazarian, Alex A. Cavallaro, Svenja Morsbach, Agnieszka Mierczynska-Vasilev, Volker Mailänder, Katharina Landfester and Krasimir Vasilev
Nanomaterials 2022, 12(4), 682; https://0-doi-org.brum.beds.ac.uk/10.3390/nano12040682 - 18 Feb 2022
Cited by 24 | Viewed by 4261
Abstract
Nanoparticles are widely used for biomedical applications such as vaccine, drug delivery, diagnostics, and therapeutics. This study aims to reveal the influence of nanoparticle surface functionalization on protein corona formation from blood serum and plasma and the subsequent effects on the innate immune [...] Read more.
Nanoparticles are widely used for biomedical applications such as vaccine, drug delivery, diagnostics, and therapeutics. This study aims to reveal the influence of nanoparticle surface functionalization on protein corona formation from blood serum and plasma and the subsequent effects on the innate immune cellular responses. To achieve this goal, the surface chemistry of silica nanoparticles of 20 nm diameter was tailored via plasma polymerization with amine, carboxylic acid, oxazolines, and alkane functionalities. The results of this study show significant surface chemistry-induced differences in protein corona composition, which reflect in the subsequent inflammatory consequences. Nanoparticles rich with carboxylic acid surface functionalities increased the production of pro-inflammatory cytokines in response to higher level of complement proteins and decreased the number of lipoproteins found in their protein coronas. On another hand, amine rich coatings led to increased expressions of anti-inflammatory markers such as arginase. The findings demonstrate the potential to direct physiological responses to nanomaterials via tailoring their surface chemical composition. Full article
(This article belongs to the Special Issue Nanoparticle-Protein Corona: A Source of Novel Molecular Targets)
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16 pages, 2208 KiB  
Article
Detection of Circulating Serum Protein Biomarkers of Non-Muscle Invasive Bladder Cancer after Protein Corona-Silver Nanoparticles Analysis by SWATH-MS
by Benito Blanco Gómez, Rubén López-Cortés, Francisco Javier Casas-Nebra, Sergio Vázquez-Estévez, Daniel Pérez-Fentes, María del Pilar Chantada-Vázquez, Susana B. Bravo and Cristina Núñez
Nanomaterials 2021, 11(9), 2384; https://0-doi-org.brum.beds.ac.uk/10.3390/nano11092384 - 13 Sep 2021
Cited by 12 | Viewed by 2157
Abstract
Because cystoscopy is expensive and invasive, a new method of detecting non-invasive muscular bladder cancer (NMIBC) is needed. This study aims to identify potential serum protein markers for NMIBC to improve diagnosis and to find treatment approaches that avoid disease progression to a [...] Read more.
Because cystoscopy is expensive and invasive, a new method of detecting non-invasive muscular bladder cancer (NMIBC) is needed. This study aims to identify potential serum protein markers for NMIBC to improve diagnosis and to find treatment approaches that avoid disease progression to a life-threatening phenotype (muscle-invasive bladder cancer, MIBC). Here, silver nanoparticles (AgNPs, 9.73 ± 1.70 nm) as a scavenging device together with sequential window acquisition of all theoretical mass spectra (SWATH-MS) were used to quantitatively analyze the blood serum protein alterations in two NMIBC subtypes, T1 and Ta, and they were compared to normal samples (HC). NMIBC’s analysis of serum samples identified three major groups of proteins, the relative content of which is different from the HC content: proteins implicated in the complement and coagulation cascade pathways and apolipoproteins. In conclusion, many biomarker proteins were identified that merit further examination to validate their useful significance and utility within the clinical management of NMIBC patients. Full article
(This article belongs to the Special Issue Nanoparticle-Protein Corona: A Source of Novel Molecular Targets)
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20 pages, 3394 KiB  
Article
A Novel Nanoproteomic Approach for the Identification of Molecular Targets Associated with Thyroid Tumors
by María García-Vence, María del Pilar Chantada-Vázquez, José Manuel Cameselle-Teijeiro, Susana B. Bravo and Cristina Núñez
Nanomaterials 2020, 10(12), 2370; https://0-doi-org.brum.beds.ac.uk/10.3390/nano10122370 - 28 Nov 2020
Cited by 16 | Viewed by 2523
Abstract
A thyroid nodule is the most common presentation of thyroid cancer; thus, it is extremely important to differentiate benign from malignant nodules. Within malignant lesions, classification of a thyroid tumor is the primary step in the assessment of the prognosis and selection of [...] Read more.
A thyroid nodule is the most common presentation of thyroid cancer; thus, it is extremely important to differentiate benign from malignant nodules. Within malignant lesions, classification of a thyroid tumor is the primary step in the assessment of the prognosis and selection of treatment. Currently, fine-needle aspiration biopsy (FNAB) is the preoperative test most commonly used for the initial thyroid nodule diagnosis. However, due to some limitations of FNAB, different high-throughput “omics” approaches have emerged that could further support diagnosis based on histopathological patterns. In the present work, formalin-fixed paraffin-embedded (FFPE) tissue specimens from normal (non-neoplastic) thyroid (normal controls (NCs)), benign tumors (follicular thyroid adenomas (FTAs)), and some common types of well-differentiated thyroid carcinoma (follicular thyroid carcinomas (FTCs), conventional or classical papillary thyroid carcinomas (CV-PTCs), and the follicular variant of papillary thyroid carcinomas (FV-PTCs)) were analyzed. For the first time, FFPE thyroid samples were deparaffinized using an easy, fast, and non-toxic method. Protein extracts from thyroid tissue samples were analyzed using a nanoparticle-assisted proteomics approach combined with shotgun LC-MS/MS. The differentially regulated proteins found to be specific for the FTA, FTC, CV-PTC, and FV-PTC subtypes were analyzed with the bioinformatic tools STRING and PANTHER showing a profile of proteins implicated in the thyroid cancer metabolic reprogramming, cancer progression, and metastasis. These proteins represent a new source of potential molecular targets related to thyroid tumors. Full article
(This article belongs to the Special Issue Nanoparticle-Protein Corona: A Source of Novel Molecular Targets)
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