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Nanomaterials
Special Issues
Novel Magnetic Nanoparticles: Synthesis and Biomedical Applications
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Novel Magnetic Nanoparticles: Synthesis and Biomedical Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 11911

Special Issue Editor

Dr. Jörg Schnorr

E-Mail Website
Guest Editor
Charité – Universitätsmedizin Berlin, Berlin, Germany
Interests: medical and molecular imaging especially MRI and MPI; preclinical development of magnetic nanoparticles for therapeutics and diagnostics

Special Issue Information

Dear Colleagues,

The development of novel magnetic nanoparticle systems for various biomedical applications has been the subject of tremendous interest over the past few decades. There are numerous research works regarding the synthesis and utilization of magnetic nanoparticles in biomedical research. Nevertheless, much still has to be established due to the complexity of magnetic nanoparticle interactions with biological systems. There is a need to elucidate the most relevant effects of synthesis on the magnetic, structural and physicochemical properties of the engineered magnetic nanoparticles and how these effects impact their biocompatibility and application in the biomedical field.

For this Special Issue of Nanomaterials, we hope to receive original papers, communications and reviews, from a broad community of various academic disciplines, focusing on recent achievements, progress and prospects in areas including, but not limited to:

  • Magnetic nanomaterials development and synthesis routes;
  • Magnetic nanoparticle characterization;
  • Surface engineering of magnetic nanomaterials for biomedical research;
  • Analytical applications of magnetic nanoparticles;
  • Novel diagnostic and therapeutic approaches;
  • Biocompatibility of magnetic nanoparticles;
  • Biomedical imaging;
  • Multifunctional magnetic nanoparticles.

Dr. Jörg Schnorr
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • magnetic nanoparticles
  • magnetic nanoparticle synthesis
  • magnetic nanoparticle characterization
  • medical imaging
  • molecular imaging
  • magnetic resonance imaging (MRI)
  • magnetic particle imaging (MPI)
  • hyperthermia
  • magnetic nanoparticle therapeutics
  • magnetic nanoparticle drug delivery
  • magnetic nanoparticle bioassays
  • multifunctional magnetic nanoparticles

Published Papers (4 papers)

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Research

18 pages, 1404 KiB  
Article
Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity
by Anastasiia S. Garanina, Alexey A. Nikitin, Tatiana O. Abakumova, Alevtina S. Semkina, Alexandra O. Prelovskaya, Victor A. Naumenko, Alexander S. Erofeev, Peter V. Gorelkin, Alexander G. Majouga, Maxim A. Abakumov and Ulf Wiedwald
Nanomaterials 2022, 12(1), 38; https://0-doi-org.brum.beds.ac.uk/10.3390/nano12010038 - 23 Dec 2021
Cited by 18 | Viewed by 3045
Abstract
Magnetic nanoparticles (MNPs) are widely considered for cancer treatment, in particular for magnetic hyperthermia (MHT). Thereby, MNPs are still being optimized for lowest possible toxicity on organisms while the magnetic properties are matched for best heating capabilities. In this study, the biocompatibility of [...] Read more.
Magnetic nanoparticles (MNPs) are widely considered for cancer treatment, in particular for magnetic hyperthermia (MHT). Thereby, MNPs are still being optimized for lowest possible toxicity on organisms while the magnetic properties are matched for best heating capabilities. In this study, the biocompatibility of 12 nm cobalt ferrite MNPs, functionalized with citrate ions, in different dosages on mice and rats of both sexes was investigated for 30 days after intraperitoneal injection. The animals’ weight, behavior, and blood cells changes, as well as blood biochemical parameters are correlated to histological examination of organs revealing that cobalt ferrite MNPs do not have toxic effects at concentrations close to those used previously for efficient MHT. Moreover, these MNPs demonstrated high specific loss power (SLP) of about 400 W g−1. Importantly the MNPs retained their magnetic properties inside tumor tissue after intratumoral administration for several MHT cycles within three days. Thus, cobalt ferrite MNPs represent a perspective platform for tumor therapy by MHT due to their ability to provide effective heating without exerting a toxic effect on the organism. This opens up new avenues for smaller MNPs sizes while their heating efficiency is maintained. Full article
(This article belongs to the Special Issue Novel Magnetic Nanoparticles: Synthesis and Biomedical Applications)
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18 pages, 4824 KiB  
Article
Tailored Magnetic Multicore Nanoparticles for Use as Blood Pool MPI Tracers
by Harald Kratz, Azadeh Mohtashamdolatshahi, Dietmar Eberbeck, Olaf Kosch, Frank Wiekhorst, Matthias Taupitz, Bernd Hamm, Nicola Stolzenburg and Jörg Schnorr
Nanomaterials 2021, 11(6), 1532; https://0-doi-org.brum.beds.ac.uk/10.3390/nano11061532 - 10 Jun 2021
Cited by 10 | Viewed by 2988
Abstract
For the preclinical development of magnetic particle imaging (MPI) in general, and the exploration of possible new clinical applications of MPI in particular, tailored MPI tracers with surface properties optimized for the intended use are needed. Here we present the synthesis of magnetic [...] Read more.
For the preclinical development of magnetic particle imaging (MPI) in general, and the exploration of possible new clinical applications of MPI in particular, tailored MPI tracers with surface properties optimized for the intended use are needed. Here we present the synthesis of magnetic multicore particles (MCPs) modified with polyethylene glycol (PEG) for use as blood pool MPI tracers. To achieve the stealth effect the carboxylic groups of the parent MCP were activated and coupled with pegylated amines (mPEG-amines) with different PEG-chain lengths from 2 to 20 kDa. The resulting MCP-PEG variants with PEG-chain lengths of 10 kDa (MCP-PEG10K after one pegylation step and MCP-PEG10K2 after a second pegylation step) formed stable dispersions and showed strong evidence of a successful reaction of MCP and MCP-PEG10K with mPEG-amine with 10 kDa, while maintaining their magnetic properties. In rats, the mean blood half-lives, surprisingly, were 2 and 62 min, respectively, and therefore, for MCP-PEG10K2, dramatically extended compared to the parent MCP, presumably due to the higher PEG density on the particle surface, which may lead to a lower phagocytosis rate. Because of their significantly extended blood half-life, MCP-PEG10K2 are very promising as blood pool tracers for future in vivo cardiovascular MPI. Full article
(This article belongs to the Special Issue Novel Magnetic Nanoparticles: Synthesis and Biomedical Applications)
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21 pages, 4633 KiB  
Article
Nanomagnetic Actuation of Hybrid Stents for Hyperthermia Treatment of Hollow Organ Tumors
by Benedikt Mues, Benedict Bauer, Anjali A. Roeth, Jeanette Ortega, Eva Miriam Buhl, Patricia Radon, Frank Wiekhorst, Thomas Gries, Thomas Schmitz-Rode and Ioana Slabu
Nanomaterials 2021, 11(3), 618; https://0-doi-org.brum.beds.ac.uk/10.3390/nano11030618 - 02 Mar 2021
Cited by 16 | Viewed by 2762
Abstract
This paper describes a magnetic nanotechnology that locally enables hyperthermia treatment of hollow organ tumors by using polymer hybrid stents with incorporated magnetic nanoparticles (MNP). The hybrid stents are implanted and activated in an alternating magnetic field to generate therapeutically effective heat, thereby [...] Read more.
This paper describes a magnetic nanotechnology that locally enables hyperthermia treatment of hollow organ tumors by using polymer hybrid stents with incorporated magnetic nanoparticles (MNP). The hybrid stents are implanted and activated in an alternating magnetic field to generate therapeutically effective heat, thereby destroying the tumor. Here, we demonstrate the feasibility of nanomagnetic actuation of three prototype hybrid stents for hyperthermia treatment of hollow organ tumors. The results show that the heating efficiency of stent filaments increases with frequency from approximately 60 W/gFe (95 kHz) to approximately 250 W/gFe (270 kHz). The same trend is observed for the variation of magnetic field amplitude; however, heating efficiency saturates at approximately 30 kA/m. MNP immobilization strongly influences heating efficiency showing a relative difference in heating output of up to 60% compared to that of freely dispersed MNP. The stents showed uniformly distributed heat on their surface reaching therapeutically effective temperatures of 43 °C and were tested in an explanted pig bile duct for their biological safety. Nanomagnetic actuation of hybrid stents opens new possibilities in cancer treatment of hollow organ tumors. Full article
(This article belongs to the Special Issue Novel Magnetic Nanoparticles: Synthesis and Biomedical Applications)
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15 pages, 4597 KiB  
Article
Magnetic Hyperthermia on γ-Fe2O3@SiO2 Core-Shell Nanoparticles for mi-RNA 122 Detection
by Marie-Charlotte Horny, Jean Gamby, Vincent Dupuis and Jean-Michel Siaugue
Nanomaterials 2021, 11(1), 149; https://0-doi-org.brum.beds.ac.uk/10.3390/nano11010149 - 09 Jan 2021
Cited by 13 | Viewed by 2100
Abstract
Magnetic hyperthermia on core-shell nanoparticles bears promising achievements, especially in biomedical applications. Here, thanks to magnetic hyperthermia, γ-Fe2O3 cores are able to release a DNA target mimicking the liver specific oncotarget miRNA-122. Our silica coated magnetic nanoparticles not only allow [...] Read more.
Magnetic hyperthermia on core-shell nanoparticles bears promising achievements, especially in biomedical applications. Here, thanks to magnetic hyperthermia, γ-Fe2O3 cores are able to release a DNA target mimicking the liver specific oncotarget miRNA-122. Our silica coated magnetic nanoparticles not only allow the grafting at their surface of a significant number of oligonucleotides but are also shown to be as efficient, by local heating, as 95 °C global heating when submitted to an alternative magnetic field, while keeping the solution at 28 °C, crucial for biological media and energy efficiency. Moreover, a slight modification of the silica coating process revealed an increased heating power, well adapted for the release of small oligonucleotides such as microRNA. Full article
(This article belongs to the Special Issue Novel Magnetic Nanoparticles: Synthesis and Biomedical Applications)
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