Self-Assembled Nanoparticles: Synthesis and Potential Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Synthesis, Interfaces and Nanostructures".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 7955

Special Issue Editor


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Guest Editor
1. Department of Organic Chemistry, University of Seville, Sevilla, Spain
2. Institute for Chemical Research (CSIC—University of Seville), Seville, Spain
Interests: nanomaterials; hybrid organic-inorganic nanocomposites; metal-organic frameworks; (bio)applications; nanocatalysis

Special Issue Information

Dear Colleagues,

Self-assembly of nanoparticles (NPs) has become a very effective and promising approach to synthesize a wide range of novel nanoscale functional materials. NPs can arrange themselves in two or three dimensions, resulting in ordered and well-organized superstructures, which can exhibit interesting collective and/or synergistic properties that are different from those of individual colloidal NPs. However, the controlled synthesis of highly ordered assemblies of NPs remains a challenging task. The driving force for self-assembly is the interaction energies between the NPs, which are mainly dictated by combination of ligand–surface and ligand–ligand interactions. Therefore, by playing with those interactions as well as with the synthetic strategy, one can engineer stable nanoassemblies with the desired structure and properties. Taking advantage of the novel properties of these NPs’ assemblies, emerging applications in the areas of biomedicine, catalysis, electronics, and photonics are being explored.

This Special Issue is open to contributions on NPs’ assemblies regarding: (i) synthetic strategies and post-synthetic functionalization methods; (ii) fundamental studies for understanding the self-assembly process and the unique interplay of molecular and nanoscale effects; (iii) characterization of collective mechanical, electrical, thermal, optical, and/or chemical properties, as well as the possible synergistic effects; and (iv) development of potential applications for the new or improved assembled nanomaterials.

Dr. Carolina Carrillo-Carrión
Guest Editor

Manuscript Submission Information

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Keywords

  • Colloidal nanoparticles
  • Self-assembly
  • Nanoassemblies
  • Driving force
  • Ligand-surface and ligand-ligand interactions
  • Collective and/or synergistic properties

Published Papers (2 papers)

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Research

10 pages, 2423 KiB  
Article
In Vitro Cellular Uptake Studies of Self-Assembled Fluorinated Nanoparticles Labelled with Antibodies
by Mona Atabakhshi-Kashi, Mónica Carril, Hossein Mahdavi, Wolfgang J. Parak, Carolina Carrillo-Carrion and Khosro Khajeh
Nanomaterials 2021, 11(8), 1906; https://0-doi-org.brum.beds.ac.uk/10.3390/nano11081906 - 24 Jul 2021
Cited by 1 | Viewed by 3351
Abstract
Nanoparticles (NPs) functionalized with antibodies (Abs) on their surface are used in a wide range of bioapplications. Whereas the attachment of antibodies to single NPs to trigger the internalization in cells via receptor-mediated endocytosis has been widely studied, the conjugation of antibodies to [...] Read more.
Nanoparticles (NPs) functionalized with antibodies (Abs) on their surface are used in a wide range of bioapplications. Whereas the attachment of antibodies to single NPs to trigger the internalization in cells via receptor-mediated endocytosis has been widely studied, the conjugation of antibodies to larger NP assemblies has been much less explored. Taking into account that NP assemblies may be advantageous for some specific applications, the possibility of incorporating targeting ligands is quite important. Herein, we performed the effective conjugation of antibodies onto a fluorescent NP assembly, which consisted of fluorinated Quantum Dots (QD) self-assembled through fluorine–fluorine hydrophobic interactions. Cellular uptake studies by confocal microscopy and flow cytometry revealed that the NP assembly underwent the same uptake procedure as individual NPs; that is, the antibodies retained their targeting ability once attached to the nanoassembly, and the NP assembly preserved its intrinsic properties (i.e., fluorescence in the case of QD nanoassembly). Full article
(This article belongs to the Special Issue Self-Assembled Nanoparticles: Synthesis and Potential Applications)
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15 pages, 30010 KiB  
Article
The Biotin–Avidin Interaction in Biotinylated Gold Nanoparticles and the Modulation of Their Aggregation
by Yanchao Lyu, Álvaro Martínez, Federica D’Incà, Fabrizio Mancin and Paolo Scrimin
Nanomaterials 2021, 11(6), 1559; https://0-doi-org.brum.beds.ac.uk/10.3390/nano11061559 - 13 Jun 2021
Cited by 9 | Viewed by 3731
Abstract
The biotin–avidin interaction is used as a binding tool for the conjugation of biomolecules for more diverse applications; these include nanoparticle conjugation. Despite this, a thorough investigation on the different aggregates that may result from the interaction of biotinylated nanoparticles (gold nanoparticles, AuNPs, [...] Read more.
The biotin–avidin interaction is used as a binding tool for the conjugation of biomolecules for more diverse applications; these include nanoparticle conjugation. Despite this, a thorough investigation on the different aggregates that may result from the interaction of biotinylated nanoparticles (gold nanoparticles, AuNPs, in this work) with avidin has not been carried out so far. In this paper, we address this problem and show the type of aggregates formed under thermodynamic and kinetic control by varying the biotinylated AuNP/avidin ratio and the order of addition of the two partners. The analysis was performed by also addressing the amount of protein able to interact with the AuNPs surface and is fully supported by the TEM images collected for the different samples and the shift of the surface plasmon resonance band. We show that the percentage of saturation depends on the size of the nanoparticles, and larger nanoparticles (19 nm in diameter) manage to accommodate a relatively larger amount of avidins than smaller ones (11 nm). The AuNPs are isolated or form small clusters (mostly dimers or trimers) when a large excess or a very low amount of avidin is present, respectively, or form large clusters at stoichiometric concentration of the protein. Daisy-like systems are formed under kinetic control conditions when nanoparticles first covered with the protein are treated with a second batch of biotinylated ones but devoid of avidin. Full article
(This article belongs to the Special Issue Self-Assembled Nanoparticles: Synthesis and Potential Applications)
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