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ncRNA
Special Issues
Role of lncRNAs in Brain Development and Disease
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Role of lncRNAs in Brain Development and Disease

A special issue of Non-Coding RNA (ISSN 2311-553X).

Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 16783

Special Issue Editors

Dr. Andrea Cerase

E-Mail Website
Guest Editor
Centre for Genomics and Child Health, Queen Mary University, London E1 4NS, UK
Interests: epigenetics; gene expression; nuclear organisation; X chromosome inactivation and reactivation; spatial control of gene expression; long non-coding RNAs at single gene and genome-wide level
Dr. Vincenza Aliperti

E-Mail
Guest Editor
Department of Biology, University of Naples Federico II, 80126 Naples, Italy
Interests: molecular biology; long non-coding RNAs; gene expression; neuronal differentiation

Special Issue Information

Dear Colleagues,

In recent years, genome-wide studies have highlighted the complexity of mammalian genomes, showing that only a small percentage of the genome codes for proteins, both in mice and humans. Most cell transcripts represent non-coding RNAs (ncRNAs), RNAs that do not code for proteins. ncRNAs are grouped into different classes and sub-classes according to their biogenesis, function, and structure. Among these, long ncRNAs (lncRNAs) are defined as RNA molecules that are longer than 200 nucleotides, lacking an open reading frame (ORF), and generally transcribed by RNA polymerase II and subjected to 5' capping, splicing, and polyadenylation.
RNAs play an active role in gene expression in many fundamental cellular processes, such as development, differentiation, proliferation, and cell metabolism. Recent research has shown that several lncRNAs are brain-specific, suggesting a key role in development and higher brain functions. Deregulation of this class of RNA has also been linked to neuropsychiatric disorders and neurodegenerative diseases.
For this Special Issue, we welcome the submission of reviews and original research articles on the topic of lncRNAs’ role in brain development and disease, with the aim of having a dedicated article collection focusing on lncRNA action and dysregulation in physiological and pathological processes.

Dr. Andrea Cerase
Dr. Vincenza Aliperti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Non-Coding RNA is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • brain
  • long non-coding RNA
  • development
  • neuronal disorders

Published Papers (2 papers)

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Review

25 pages, 3064 KiB  
Review
Long Non-Coding RNA (lncRNA) Roles in Cell Biology, Neurodevelopment and Neurological Disorders
by Vincenza Aliperti, Justyna Skonieczna and Andrea Cerase
Non-Coding RNA 2021, 7(2), 36; https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7020036 - 17 Jun 2021
Cited by 57 | Viewed by 7601
Abstract
Development is a complex process regulated both by genetic and epigenetic and environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression in several tissues including the brain. Altered expression of lncRNAs has been linked to several neurodegenerative, [...] Read more.
Development is a complex process regulated both by genetic and epigenetic and environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression in several tissues including the brain. Altered expression of lncRNAs has been linked to several neurodegenerative, neurodevelopmental and mental disorders. The identification and characterization of lncRNAs that are deregulated or mutated in neurodevelopmental and mental health diseases are fundamental to understanding the complex transcriptional processes in brain function. Crucially, lncRNAs can be exploited as a novel target for treating neurological disorders. In our review, we first summarize the recent advances in our understanding of lncRNA functions in the context of cell biology and then discussing their association with selected neuronal development and neurological disorders. Full article
(This article belongs to the Special Issue Role of lncRNAs in Brain Development and Disease)
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22 pages, 1002 KiB  
Review
Non-Syndromic Intellectual Disability and Its Pathways: A Long Noncoding RNA Perspective
by Isabela I. Barros, Vitor Leão, Jessica O. Santis, Reginaldo C. A. Rosa, Danielle B. Brotto, Camila B. Storti, Ádamo D. D. Siena, Greice A. Molfetta and Wilson A. Silva, Jr.
Non-Coding RNA 2021, 7(1), 22; https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7010022 - 11 Mar 2021
Cited by 2 | Viewed by 8528
Abstract
Non-syndromic intellectual disability (NS-ID or idiopathic) is a complex neurodevelopmental disorder that represents a global health issue. Although many efforts have been made to characterize it and distinguish it from syndromic intellectual disability (S-ID), the highly heterogeneous aspect of this disorder makes it [...] Read more.
Non-syndromic intellectual disability (NS-ID or idiopathic) is a complex neurodevelopmental disorder that represents a global health issue. Although many efforts have been made to characterize it and distinguish it from syndromic intellectual disability (S-ID), the highly heterogeneous aspect of this disorder makes it difficult to understand its etiology. Long noncoding RNAs (lncRNAs) comprise a large group of transcripts that can act through various mechanisms and be involved in important neurodevelopmental processes. In this sense, comprehending the roles they play in this intricate context is a valuable way of getting new insights about how NS-ID can arise and develop. In this review, we attempt to bring together knowledge available in the literature about lncRNAs involved with molecular and cellular pathways already described in intellectual disability and neural function, to better understand their relevance in NS-ID and the regulatory complexity of this disorder. Full article
(This article belongs to the Special Issue Role of lncRNAs in Brain Development and Disease)
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