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ncRNA
Special Issues
Non-Coding RNA and Tumor Cell Motility
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Non-Coding RNA and Tumor Cell Motility

A special issue of Non-Coding RNA (ISSN 2311-553X).

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 5318

Special Issue Editor

Prof. Dr. Suresh K Alahari

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, LSU School of Medicine, CSRB 406, 533 Bolivar Street, New Orleans, LA 70112, USA
Interests: cell adhesion; Nischarin; tumor cell migration; invasion, microRNA, lncRNA
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cell migration is a key characteristic of many cell types and can be a crucial feature during developmental morphogenesis, tissue repair, wound healing, and regeneration. In addition to being involved in normal cellular behavior, cell migration can also be a malignant cell feature in certain types of pathogenesis, such as tumor metastasis. With this Special Issue on non-coding RNA (ncRNA) and cell migration, we would like to unravel the role played by ncRNA types during cellular migration, both in malignant stages and in wild types.

Prof. Dr. Suresh K Alahari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Non-Coding RNA is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cell migration
  • ncRNA in cell migration
  • ncRNA in metastasis
  • ncRNA in wound healing
  • ncRNA in morphogenesis
  • ncRNA in cancers
  • ncRNA in cancer stem cells
  • ncRNA in cell adhesion
  • ncRNA in epithelial–mesenchymal transition (EMT)

Published Papers (1 paper)

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Research

15 pages, 2691 KiB  
Article
Long Non-Coding PROX1-AS1 Expression Correlates with Renal Cell Carcinoma Metastasis and Aggressiveness
by Magdalena Rudzinska, Karolina H. Czarnecka-Chrebelska, Ekaterina B. Kuznetsova, Sofya V. Maryanchik, Alessandro Parodi, Dmitry O. Korolev, Nataliya Potoldykova, Yulia Svetikova, Andrey Z. Vinarov, Marina V. Nemtsova and Andrey A. Zamyatnin, Jr.
Non-Coding RNA 2021, 7(2), 25; https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna7020025 - 10 Apr 2021
Cited by 4 | Viewed by 4539
Abstract
Long non-coding RNAs (lncRNAs) can be specifically expressed in different tissues and cancers. By controlling the gene expression at the transcriptional and translational levels, lncRNAs have been reported to be involved in tumor growth and metastasis. Recent data demonstrated that multiple lncRNAs have [...] Read more.
Long non-coding RNAs (lncRNAs) can be specifically expressed in different tissues and cancers. By controlling the gene expression at the transcriptional and translational levels, lncRNAs have been reported to be involved in tumor growth and metastasis. Recent data demonstrated that multiple lncRNAs have a crucial role in renal cell carcinoma (RCC) progression—the most common malignant urogenital tumor. In the present study, we found a trend towards increased PROX1 antisense RNA 1 (PROX1-AS1) expression in RCC specimens compared to non-tumoral margins. Next, we found a positive correlation between PROX1-AS1 expression and the occurrence of distant and lymph node metastasis, higher tumor stage (pT1 vs. pT2 vs. pT3–T4) and high-grade (G1/G2 vs. G3/G4) clear RCC. Furthermore, global demethylation in RCC-derived cell lines (769-P and A498) and human embryonic kidney 293 (HEK293) cells induced a significant increase of PROX1-AS1 expression level, with the most remarkable change in HEK293 cells. In line with this evidence, bisulfite sequencing analysis confirmed the specific demethylation of bioinformatically selected CpG islands on the PROX1-AS1 promoter sequence in the HEK293 cell line but not in the tumor cells. Additionally, the human specimen analysis showed the hemimethylated state of CG dinucleotides in non-tumor kidney tissues, whereas the tumor samples presented the complete, partial, or no demethylation of CpG-islands. In conclusion, our study indicated that PROX1-AS1 could be associated with RCC progression, and further investigations may define its role as a new diagnostic marker and therapeutic target. Full article
(This article belongs to the Special Issue Non-Coding RNA and Tumor Cell Motility)
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