Special Issue "Non-coding RNAs in Biology of Viruses"

A special issue of Non-Coding RNA (ISSN 2311-553X).

Deadline for manuscript submissions: closed (31 March 2021).

Special Issue Editor

Dr. Sébastien Pfeffer
E-Mail Website
Guest Editor
Institut de Biologie Moléculaire et Cellulaire du CNRS, Université de Strasbourg, 67084 Strasbourg, France
Interests: Herpesviruses; arboviruses; microRNA; RNAi; innate immunity

Special Issue Information

Dear Colleagues,

The importance of non-coding (nc) RNA in diverse fields of biology has risen exponentially in the past decade. Among these fields, virology is no exception, and there has been an innumerable number of reports regarding the contribution of these molecules to the infection process. Viruses are well known for their capacity to hijack cellular pathways and can either express their own long and small ncRNAs to regulate host gene expression or use cellular ncRNAs to confer them an advantage in a tissue-specific manner. Conversely, the infected organism can respond to the infection and fight against the invading pathogen using regulatory RNAs. This dual-mode of interaction is at the heart of the study of the role of ncRNA in host-virus interaction, and we have now started to gain a good understanding of the molecular mechanisms at play. This Special Issue is focused on recent developments in the role and regulation of non-coding RNAs (including microRNA, lncRNA, and circRNA) in the biology of virus infection. A full understanding of these aspects will further our knowledge of the biology of viruses and could pave the way toward novel therapeutic approaches.

We are looking forward to receiving your contributions for this Special Issue.

Dr. Sébastien Pfeffer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Non-Coding RNA is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • RNA biology
  • microRNA
  • lncRNA
  • circular RNA
  • virus
  • gene expression regulation
  • host-pathogen interaction

Published Papers (1 paper)

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Research

Communication
Human Cytomegalovirus-Encoded microRNAs Can Be Found in Saliva Samples from Renal Transplant Recipients
Non-Coding RNA 2020, 6(4), 50; https://0-doi-org.brum.beds.ac.uk/10.3390/ncrna6040050 - 18 Dec 2020
Cited by 2 | Viewed by 2180
Abstract
Human cytomegalovirus (HCMV) infections are common following renal transplantation and may have long-lasting effects. HCMV can be measured directly by viral DNA or indirectly via host immune responses. HCMV-encoded microRNA (miRNA) may alter the pathobiology of HCMV infections and contribute to the progression [...] Read more.
Human cytomegalovirus (HCMV) infections are common following renal transplantation and may have long-lasting effects. HCMV can be measured directly by viral DNA or indirectly via host immune responses. HCMV-encoded microRNA (miRNA) may alter the pathobiology of HCMV infections and contribute to the progression of HCMV disease. HCMV-encoded miRNAs can be detected in blood but have not been sought in saliva. We investigated saliva samples from 32 renal transplant recipients (RTR) and 12 seropositive healthy controls for whom immunological data was available. Five HCMV-encoded miRNAs (miR-UL112-5p, miR-US5-2-3p, miR-UL36, miR-US25-2-3p and miR-UL22A) were sought using primer probe assays. HCMV miRNA species were detected in saliva from 15 RTR and 3 healthy controls, with miR-US5-2-3p most commonly detected. The presence of HCMV miRNAs associated with increased T-cell responses to HCMV IE-1 in RTR, suggesting a link with frequent reactivations of HCMV. Full article
(This article belongs to the Special Issue Non-coding RNAs in Biology of Viruses)
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