Special Issue "Dynamic Vascular-Glial-Neuronal Interactions in Health and Disease"
A special issue of Neuroglia (ISSN 2571-6980).
Deadline for manuscript submissions: closed (10 October 2021).
Interests: neurovascular; arteriole; pressure; calcium; ion channels; cerebral blood flow; astrocyte; microglia; myogenic; hypertension
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Dynamic crosstalk interactions among components of the neurovascular unit (NVU) maintain brain homeostasis. Importantly, neural and glial-derived signals regulate cerebral blood flow and the energetic demands of the brain. Impairments in these key constitutive processes uncouple communication at the NVU, impair cerebral perfusion, increase inflammation, and lead to progressive neurodegeneration.
Efforts have been devoted to the understanding of both physiological and pathological intercellular crosstalk at the NVU. Physiological processes such as cerebral autoregulation, neurovascular coupling, and vasculo-neuronal coupling are common pathways used to understand the state of oxygen and glucose delivery to the brain. Notably, both intrinsic and extrinsic cellular mechanisms can differentially alter the functional integrity of the NVU. Poorly understood are the cell-specific signaling pathways, as well as the stimuli thresholds (i.e., ischemia, intravascular and intracranial pressures) by which certain conditions switch from physiology to pathology. In addition, the contribution of cardiovascular risk factors and glymphatic dysfunction on neurodegeneration, vascular dementia, and Alzheimer’s are current critical areas of research.
This Special Issue seeks papers related to how disease processes impact brain hemodynamics, perfusion, and metabolism. Highlights on the importance of brain region specificity, on circuit connectivity, as well as studies addressing the molecular mechanisms underlying cell-specific crosstalk in health and disease are welcome.
Prof. Jessica Filosa
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Neuroglia is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- neurovascular coupling
- neurovascular unit
- intercellular crosstalk
- vascular function
- ion channels
- blood–brain barrier integrity