Special Issue "Advanced Glycation End Products (AGEs): Link between Modern Health and Disease"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 20 February 2022.

Special Issue Editor

Dr. Leni Rose Rivera
E-Mail Website
Guest Editor
Faculty of Health, School of Medicine, Geelong Waurn Ponds Campus, Deakin University, Waurn Ponds, Australia
Interests: gut health; gut microbiome; obesity; AGEs; NAFLD; diet

Special Issue Information

Dear Colleagues,

A traditional whole-food diet consists of higher intakes of foods such as vegetables, fruits, seafood, whole grains, lean meat, nuts, and legumes, with the avoidance of processed foods. Currently, in both developed and emerging economies there is a preference to consume nutrient-poor, energy-dense, and highly processed foods. Many people are both overfed and undernourished. This transition from the traditional to the modern diet has seen increases in obesity, nonalcoholic fatty liver disease, and other metabolic and behavioral disorders. Excessive amounts of certain components of the modern diet have been implicated in multiple organ failure. These include excessive fats, sugars, and advanced glycation end products (AGEs). AGEs are a group of chemically heterogeneous compounds formed by the non-enzymatic modification of proteins by reducing sugars. These compounds are found in large amounts in the modern diet and are also produced endogenously at an increased rate in diabetes. AGEs also have many potentially harmful effects and have been implicated in the development and progression of diabetic pathology and a range of other chronic disease states. This Special Issue will delve into exploring the link between AGEs and modern health and disease.

Dr. Leni Rose Rivera
Guest Editor

Manuscript Submission Information

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Keywords

  • Advanced glycation end products
  • Obesity
  • Non-alcoholic fatty liver disease
  • Diabetes
  • Cognition and dementia
  • Gut microbiome
  • Metabolic disorders
  • Processed foods
  • Cardiovascular disease
  • Mitochondria and oxidative stress
  • Kidney diseases

Published Papers (1 paper)

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Systematic Review
Advanced Glycation End-Products in Common Non-Infectious Liver Diseases: Systematic Review and Meta-Analysis
Nutrients 2021, 13(10), 3370; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13103370 - 25 Sep 2021
Viewed by 619
Abstract
Background: Excessive intake of fructose, glucose and alcohol is associated with the development of non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). At the same time, these dietetic factors create an environment favorable for the generation of advanced glycation end-products. For [...] Read more.
Background: Excessive intake of fructose, glucose and alcohol is associated with the development of non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). At the same time, these dietetic factors create an environment favorable for the generation of advanced glycation end-products. For this reason, advanced glycation end-products (AGEs) are hypothesized to play role in the development of NAFLD and ALD. In this systematic review and meta-analysis, we explore the relationship between NAFLD and ALD with AGE levels, including their diagnostic accuracy. Methods: The systematic review and meta-analysis has been pre-registered with PROSPERO (CRD42021240954) and was performed in accordance with the PRISMA guidelines. Meta-analyses were performed using the meta R package. Results: We have obtained 11 studies meeting our inclusion criteria, reporting data on 1844 participants (909 with NAFLD, 169 with ALD and 766 healthy controls). NAFLD was associated with significantly higher AGE fluorescence and serum N-(carboxyethyl)lysine (CEL) levels. Patients with alcoholic cirrhosis had significantly higher levels of N-(carboxymethyl)lysine (CML). Only individual studies examined AGEs in the context of their diagnostic accuracy. AGE fluorescence distinguished low and moderate steatosis with an AUC of 0.76. The ratio of CML, CEL and pentosidine to a soluble variant of the AGE receptor differentiated patients with NAFLD from healthy controls with high AUC (0.83–0.85). Glyceraldehyde-derived AGE separated non-alcoholic fatty liver (NAFL) from non-alcoholic steatohepatitis (NASH) with acceptable performance (AUC 0.78). Conclusions: In conclusion, NAFLD and ALD are associated with significantly higher levels of several AGEs. More research is needed to examine the diagnostic accuracy of AGEs, however individual studies show that AGEs perform well in distinguishing NAFL from NASH. Full article
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