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Effect of Breastfeeding on Child Growth and Gut Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Pediatric Nutrition".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 2118

Special Issue Editor


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Guest Editor
UGC Pediatría, Hospital Clínico San Cecilio de Granada, University of Granada, Granada, Spain
Interests: neonatal health development

Special Issue Information

Dear Colleagues,

Breast milk is the ideal food for the nutrition of newborns and infants. Among its beneficial effects, breastfeeding allows the optimal development of growth and a newborn’s immune system. Breast milk is a highly complex living fluid that contains proteins, carbohydrates, lipids, cells, and other biologically important components. Its influence on the health of newborns, its repercussions on some chronic pathologies in adults, and its beneficial role in the premature newborn are the subject of interesting studies. 

This Special Issue particularly aims to deepen our knowledge of better-known factors of breast milk that may be related to the intestinal maturation process of a newborn and the establishment of a stable microbiota and delve into the effects on the modulation of a newborn’s immune response and the development of an atopic phenotype in the infant, as well as develop a more thorough understanding of the influence of breast milk on somatic growth and its protective role against metabolic syndrome in adults. 

This Special Issue welcomes original research, systematic reviews, and meta-analyses on, but not limited to:

  • Breastfeeding and its influence on the establishment of a newborn’s microbiota and its relationship with the development of infant metabolic syndrome;
  • Breastfeeding and breastfeeding with donated milk in very low-weight premature newborns and its relationship with the prevention of atopy;
  • Breastfeeding and its role in the prevention of pathologies among premature newborns (e.g., bronchopulmonary dysplasia, necrotizing enterocolitis).

Prof. Dr. José Uberos
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • breastfeeding
  • human milk
  • microbiota
  • gut health
  • child growth

Published Papers (1 paper)

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Research

8 pages, 1243 KiB  
Article
Digested Human Colostrum Reduces Interleukin-8 Production in Induced Human Intestinal Epithelial Cells
by Yang Lyu and Yimin Chen
Nutrients 2022, 14(14), 2787; https://0-doi-org.brum.beds.ac.uk/10.3390/nu14142787 - 06 Jul 2022
Viewed by 1784
Abstract
Little is known about the impact of human colostrum on infant intestinal health following digestion. The aim of this study was to compare the effect of digested versus undigested human colostrum on inflammation and cytotoxicity in human intestinal epithelial cells (Caco2BBe) stimulated with [...] Read more.
Little is known about the impact of human colostrum on infant intestinal health following digestion. The aim of this study was to compare the effect of digested versus undigested human colostrum on inflammation and cytotoxicity in human intestinal epithelial cells (Caco2BBe) stimulated with lipopolysaccharides (LPS) or tumor necrosis factor (TNF). Colostrum samples (days 2–8 postpartum) from ten mothers of preterm infant were applied. Caco2BBe cells were pretreated by digested or undigested colostrum before stimulation with LPS or TNF. The inflammatory response was determined by measuring the production of interleukin-8 (IL-8) from cells using enzyme linked immunosorbent assay (ELISA). Cytotoxicity was examined by measuring the release of lactate dehydrogenase (LDH) from the cells. Digested colostrum significantly reduced IL-8 production under LPS and TNF stimulation compared with undigested colostrum. Individual colostrum samples exhibited wide variance in the ability to suppress IL-8 production and cytotoxicity in Caco2BBe cells. In vitro-digested human colostrum suppressed an inflammatory response more than undigested human colostrum in an induced intestinal cell culture model. Full article
(This article belongs to the Special Issue Effect of Breastfeeding on Child Growth and Gut Health)
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