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Dietary Intake and Ovarian Cancer

A special issue of Nutrients (ISSN 2072-6643).

Deadline for manuscript submissions: closed (1 July 2019) | Viewed by 10416

Special Issue Editors


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Guest Editor
1. Scientific Directorate, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
2. Department of Life Sciences and Public Health, Faculty of Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Interests: personalized medicine; precision medicine; gynecologic oncology; clinical research
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Department of Translational Medicine and Surgery, School of Medicine, Catholic University, 00168 Rome, Italy
2. Center for Diagnosis and Treatment of Digestive Diseases, CEMAD, Gastroenterology Department, Fondazione Policlinico Gemelli, IRCCS, 00168 Rome, Italy
Interests: gastroenterology; oncology; digestive cancer; diverticular disease; cancer prevention; inflammatory bowel diseases; microbial communities; bioinformatics and computational biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ovarian cancer is the seventh most common cause of cancer death among women worldwide. The majority of cases are usually diagnosed at an advanced stage, contributing to poor survival. The noticeable relationship between ovarian cancer incidence and geographical regions suggested that dietary habits and ethnic variations are potentially modifiable factors, whose etiologic role in ovarian cancer risk, however, remains undefined. Although multiple epidemiologic studies have explored the associations between dietary intake and the risk of ovarian cancer, no definite conclusion have been drawn, and the dietary intake varieties, as well as pathological types of ovarian cancer, increase the complexity of this research topic. On the other hand, evidence based on experimental studies suggested that nutritional status improves surgical and oncological outcomes during ovarian cancer treatment. The scientific community needs to strengthen its evidence base and continue to enhance its knowledge on the role of diet (in all forms), in order to include dietary intake evaluation and nutritional status in the multifactorial fight against ovarian cancer.

Prof. Dr. Giovanni Scambia
Prof. Dr. Antonio Gasbarrini
Guest Editors

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Keywords

  • Ovarian cancer
  • Dietary intake
  • Nutritional status
  • Nutrition therapy
  • Disease-related malnutrition
  • ERAS protocols in gynecologicic oncology
  • Personalized Medicine

Published Papers (1 paper)

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Review

19 pages, 1231 KiB  
Review
Nutritional Interventions to Improve Clinical Outcomes in Ovarian Cancer: A Systematic Review of Randomized Controlled Trials
by Emanuele Rinninella, Anna Fagotti, Marco Cintoni, Pauline Raoul, Giuseppe Scaletta, Lorena Quagliozzi, Giacinto Abele Donato Miggiano, Giovanni Scambia, Antonio Gasbarrini and Maria Cristina Mele
Nutrients 2019, 11(6), 1404; https://0-doi-org.brum.beds.ac.uk/10.3390/nu11061404 - 21 Jun 2019
Cited by 31 | Viewed by 9974
Abstract
Among all gynaecological neoplasms, ovarian cancer has the highest rate of disease-related malnutrition, representing an important risk factor of postoperative mortality and morbidity. Hence, the importance of finding effective nutritional interventions is crucial to improve ovarian cancer patient’s well-being and survival. This systematic [...] Read more.
Among all gynaecological neoplasms, ovarian cancer has the highest rate of disease-related malnutrition, representing an important risk factor of postoperative mortality and morbidity. Hence, the importance of finding effective nutritional interventions is crucial to improve ovarian cancer patient’s well-being and survival. This systematic review of randomized controlled trials (RCTs) aims at assessing the effects of nutritional interventions on clinical outcomes such as overall survival, progression-free survival, length of hospital stay (LOS), complications following surgery and/or chemotherapy in ovarian cancer patients. Three electronic bibliographic databases (MEDLINE, Web of Science, and Cochrane Central Register of Controlled Trials) were used to conduct a systematic literature search based on fixed inclusion and exclusion criteria, until December 2018. A total of 14 studies were identified. Several early postoperative feeding interventions studies (n = 8) were retrieved mainly demonstrating a reduction in LOS and an ameliorated intestinal recovery after surgery. Moreover, innovative nutritional approaches such as chewing gum intervention (n = 1), coffee consumption (n = 1), ketogenic diet intervention (n = 2) or fruit and vegetable juice concentrate supplementation diet (n = 1) and short-term fasting (n = 1) have been shown as valid and well-tolerated nutritional strategies improving clinical outcomes. However, despite an acceptable number of prospective trials, there is still a lack of homogeneous and robust endpoints. In particular, there is an urgent need of RCTs evaluating overall survival and progression-free survival during ovarian oncology treatments. Further high-quality studies are warranted, especially prospective studies and large RCTs, with more homogeneous types of intervention and clinical outcomes, including a more specific sampling of ovarian cancer women, to identify appropriate and effective nutritional strategies for this cancer, which is at high risk of malnutrition. Full article
(This article belongs to the Special Issue Dietary Intake and Ovarian Cancer)
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