Special Issue "Plant Polyphenols and Human Health: Novel Findings for Future Therapeutic Developments"
Deadline for manuscript submissions: 15 December 2021.
Interests: natural substances; plant phytocomplexes; polyphenols; terpenoids; cancer chemoprevention; chemoresistance; STAT3; DNA-damage; metabolic reprogramming; genoprotection; hypoglycemic activity; antiglycative properties; antioxidant activity; immunomodulation
Interests: terpenoids; polyphenols; chemoprevention; hepatocellular carcinoma; multidrug resistance; ABC-transporters; Nrf2; epithelial–mesenchymal transition (EMT)
We are pleased to invite you to contribute to this Special Issue entitled “Plant Polyphenols and Human Health: Novel Findings for Future Therapeutic Developments”.
Plant polyphenols are a large class of diverse secondary metabolites, ranging from simple phenolic acids to more complex molecules, including stilbenes, flavonoids, and tannins, all sharing the presence of multiple phenol units in their structure.
They are widely distributed in different plant species, where they perform several structural, metabolic, and defense functions and mediate biotic and abiotic interactions.
A plethora of beneficial properties, including antioxidant, anti-inflammatory, antimicrobial and antiproliferative, have been associated to polyphenol-enriched food and plant byproducts, thus suggesting a possible role of these compounds in the prevention or treatment of several pathologies, such as neurodegenerative diseases, metabolic syndrome, diabetes, and cancer. Recent evidence has also highlighted the ability of some phenolics to boost antioxidant endogenous defenses, thus favoring health maintenance and infectious resilience.
Consequently, polyphenols appear to be interesting candidates for both pharmaceutical and nutraceutical applications. However, some pharmacokinetic issues, including reduced intestinal absorption and bioavailability, and rapid metabolic modifications, should be assessed to fully exploit their remarkable properties.
This Special Issue aims at collecting original articles and review papers evaluating the biological activities of plant polyphenols and phenolic-based plant byproducts, the mechanisms involved, and their clinical relevance. Moreover, papers addressing innovative pharmaceutical formulations to improve the bioavailability of these compounds are welcome.
Dr. Antonella Di Sotto
Dr. Silvia Di Giacomo
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Phenolic-based plant byproducts
- Metabolic syndrome
- Viral infectious
- Synergistic effects
- Phenolic acids
- Gut microbiome