Special Issue "Plant Polyphenols and Human Health: Novel Findings for Future Therapeutic Developments"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 15 December 2021.

Special Issue Editors

Dr. Antonella Di Sotto
E-Mail Website
Guest Editor
Department of Physiology and Pharmacology “V. Erspamer”, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy
Interests: natural substances; plant phytocomplexes; polyphenols; terpenoids; cancer chemoprevention; chemoresistance; STAT3; DNA-damage; metabolic reprogramming; genoprotection; hypoglycemic activity; antiglycative properties; antioxidant activity; immunomodulation
Dr. Silvia Di Giacomo
E-Mail Website
Guest Editor
Department of Physiology and Pharmacology “V. Erspamer”, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy
Interests: terpenoids; polyphenols; chemoprevention; hepatocellular carcinoma; multidrug resistance; ABC-transporters; Nrf2; epithelial–mesenchymal transition (EMT)

Special Issue Information

Dear Colleagues, 

We are pleased to invite you to contribute to this Special Issue entitled “Plant Polyphenols and Human Health: Novel Findings for Future Therapeutic Developments”. 

Plant polyphenols are a large class of diverse secondary metabolites, ranging from simple phenolic acids to more complex molecules, including stilbenes, flavonoids, and tannins, all sharing the presence of multiple phenol units in their structure.

They are widely distributed in different plant species, where they perform several structural, metabolic, and defense functions and mediate biotic and abiotic interactions.

A plethora of beneficial properties, including antioxidant, anti-inflammatory, antimicrobial and antiproliferative, have been associated to polyphenol-enriched food and plant byproducts, thus suggesting a possible role of these compounds in the prevention or treatment of several pathologies, such as neurodegenerative diseases, metabolic syndrome, diabetes, and cancer. Recent evidence has also highlighted the ability of some phenolics to boost antioxidant endogenous defenses, thus favoring health maintenance and infectious resilience.

Consequently, polyphenols appear to be interesting candidates for both pharmaceutical and nutraceutical applications. However, some pharmacokinetic issues, including reduced intestinal absorption and bioavailability, and rapid metabolic modifications, should be assessed to fully exploit their remarkable properties.

This Special Issue aims at collecting original articles and review papers evaluating the biological activities of plant polyphenols and phenolic-based plant byproducts, the mechanisms involved, and their clinical relevance. Moreover, papers addressing innovative pharmaceutical formulations to improve the bioavailability of these compounds are welcome.

Dr. Antonella Di Sotto
Dr. Silvia Di Giacomo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Polyphenols
  • Phenolic-based plant byproducts
  • Metabolic syndrome
  • Diabetes
  • Viral infectious
  • Liver
  • Neuroprotection
  • Synergistic effects
  • Phenolic acids
  • Tannins
  • Gut microbiome

Published Papers (5 papers)

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Research

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Article
Combination of Trans-Resveratrol and ε-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression
Nutrients 2021, 13(11), 3677; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13113677 - 20 Oct 2021
Viewed by 471
Abstract
Stilbenes are a major grapevine class of phenolic compounds, known for their biological activities, including anti-inflammatory and antioxidant, but never studied in combination. We aimed to evaluate the effect of trans-resveratrol + ε-viniferin as an antioxidant mixture and its role in inflammatory development [...] Read more.
Stilbenes are a major grapevine class of phenolic compounds, known for their biological activities, including anti-inflammatory and antioxidant, but never studied in combination. We aimed to evaluate the effect of trans-resveratrol + ε-viniferin as an antioxidant mixture and its role in inflammatory development an in vivo model of severe acute liver failure induced with TAA. Trans-resveratrol + trans-ε-viniferin (5 mg/kg each) was administered to Wistar rats. Resveratrol + ε-viniferin significantly decreased TBARS and SOD activity and restored CAT and GST activities in the treated group. This stilbene combination reduced the expression of TNFα, iNOS, and COX-2, and inhibited MMP-9. The combination of resveratrol + ε-viniferin had a hepatoprotective effect, reducing DNA damage, exhibiting a protective role on the antioxidant pathway by altering SOD, CAT, and GST activities; by downregulating TNFα, COX-2, and iNOS; and upregulating IL-10. Our results suggested that adding viniferin to resveratrol may be more effective in hepatoprotection than resveratrol alone, opening a new perspective on using this stilbene combination in functional diets. Full article
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Article
Vascular Effects of the Polyphenolic Nutraceutical Supplement Taurisolo®: Focus on the Protection of the Endothelial Function
Nutrients 2021, 13(5), 1540; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13051540 - 02 May 2021
Cited by 2 | Viewed by 1619
Abstract
Preservation of vascular endothelium integrity and functionality represents an unmet medical need. Indeed, endothelial dysfunction leads to decreased nitric oxide biosynthesis, which is prodromic of hypertension and hypercoagulability. In this panorama, the nutraceutical supplement Taurisolo®, a polyphenolic extract from Aglianico cultivar [...] Read more.
Preservation of vascular endothelium integrity and functionality represents an unmet medical need. Indeed, endothelial dysfunction leads to decreased nitric oxide biosynthesis, which is prodromic of hypertension and hypercoagulability. In this panorama, the nutraceutical supplement Taurisolo®, a polyphenolic extract from Aglianico cultivar grape, rich in catechin and procyanidins, was evaluated as a vasoprotective, vasorelaxing, anti-hypertensive and anti-coagulant agent in: cell lines, isolated vessels, in vivo models of chronic hypertension and hypercoagulability, and in clinical tests of endothelial reactivity. Taurisolo® demonstrated to fully protect vascular cell viability from oxidative stimulus at 100 µg/mL and evoke vasorelaxing effects (Emax = 80.6% ± 1.9 and pEC50 = 1.19 ± 0.03) by activation of the Sirtuins-AMPK-pathway. Moreover, Taurisolo®, chronically administered at 20 mg/Kg/die in in vivo experiments, inhibited the onset of cardiac hypertrophy (heart weight/rat weight = 3.96 ± 0.09 vs. 4.30 ± 0.03), hypercoagulability (decrease of fibrinogen vs. control: p < 0.01) and hypertension (mean of Psys: 200 ± 2 vs. control 234 ± 2 mmHg) and improved endothelial function (Emax = 88.9% ± 1.5 vs. control 59.6% ± 3.6; flow-mediated dilation in healthy volunteers after 400 mg twice daily for 8 weeks vs. baseline: p = 0.019). In conclusion, Taurisolo® preserves the vascular function against ox-inflamm-ageing process and the consequent cardiovascular accidents. Full article
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Review

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Review
Propolis and Its Gastroprotective Effects on NSAID-Induced Gastric Ulcer Disease: A Systematic Review
Nutrients 2021, 13(9), 3169; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13093169 - 11 Sep 2021
Viewed by 806
Abstract
Gastric ulcer disease induced by the consumption of NSAIDs is a major public health problem. The therapy used for its treatment causes adverse effects in the patient. Propolis is a natural product that has been used for the treatments of different diseases around [...] Read more.
Gastric ulcer disease induced by the consumption of NSAIDs is a major public health problem. The therapy used for its treatment causes adverse effects in the patient. Propolis is a natural product that has been used for the treatments of different diseases around the world. Nevertheless, there is little information about the activity of propolis in gastric ulcers caused by treatment with NSAIDs. Therefore, this review evaluates and compares the gastroprotective potential of propolis and its function against NSAID-induced gastric ulcers, for which a systematic search was carried out in the PubMed and ScienceDirect databases. The main criteria were articles that report the gastroprotective activity of propolis against the damage produced by NSAIDs in the gastric mucosa. Gastroprotection was related to the antioxidant, antisecretory, and cytoprotective effects, as well as the phenolic compounds present in the chemical composition of propolis. However, most of the studies used different doses of NSAIDs and propolis and evaluated different parameters. Propolis has proven to be a good alternative for the treatment of gastric ulcer disease. However, future studies should be carried out to identify the compounds responsible for these effects and to determine their potential use in people. Full article
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Review
Effect of Polyphenols Intake on Obesity-Induced Maternal Programming
Nutrients 2021, 13(7), 2390; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13072390 - 13 Jul 2021
Viewed by 719
Abstract
Excess caloric intake and body fat accumulation lead to obesity, a complex chronic disease that represents a significant public health problem due to the health-related risk factors. There is growing evidence showing that maternal obesity can program the offspring, which influences neonatal phenotype [...] Read more.
Excess caloric intake and body fat accumulation lead to obesity, a complex chronic disease that represents a significant public health problem due to the health-related risk factors. There is growing evidence showing that maternal obesity can program the offspring, which influences neonatal phenotype and predispose offspring to metabolic disorders such as obesity. This increased risk may also be epigenetically transmitted across generations. Thus, there is an imperative need to find effective reprogramming approaches in order to resume normal fetal development. Polyphenols are bioactive compounds found in vegetables and fruits that exert its anti-obesity effect through its powerful anti-oxidant and anti-inflammatory activities. Polyphenol supplementation has been proven to counteract the prejudicial effects of maternal obesity programming on progeny. Indeed, some polyphenols can cross the placenta and protect the fetal predisposition against obesity. The present review summarizes the effects of dietary polyphenols on obesity-induced maternal reprogramming as an offspring anti-obesity approach. Full article
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Other

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Systematic Review
The Effects of Fruit-Derived Polyphenols on Cognition and Lung Function in Healthy Adults: A Systematic Review and Meta-Analysis
Nutrients 2021, 13(12), 4273; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13124273 (registering DOI) - 27 Nov 2021
Viewed by 368
Abstract
Polyphenols are plant derived nutrients that influence oxidative stress and inflammation and therefore may have positive benefits on cognition and lung function. This systematic review and meta-analysis aimed to evaluate the effects of fruit derived polyphenol intakes on cognition and lung capacity in [...] Read more.
Polyphenols are plant derived nutrients that influence oxidative stress and inflammation and therefore may have positive benefits on cognition and lung function. This systematic review and meta-analysis aimed to evaluate the effects of fruit derived polyphenol intakes on cognition and lung capacity in healthy adults. In August 2020 and October 2021, Medline and Google Scholar were used to search for relevant studies examining the effects of fruit derived polyphenol intakes on cognition and/or lung function in healthy adults (<70 years old). Fourteen studies related to cognition (409 healthy subjects) and seven lung/respiratory studies (20 788 subjects) were used for the systematic review using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. The meta-analysis (using six cognition and three lung function studies) indicated a protective effect on lung function from dietary intakes of fruit-derived polyphenols. Neither a benefit nor decrement from fruit-derived polyphenol intakes were detected for cognition. Human intervention trials examining the effects of polyphenol supplementation on lung function in healthy adults are scarce and intervention studies are warranted. More conclusive results are needed to provide recommendations for polyphenol supplementation to support aspects of cognition. Full article
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