Special Issue "Food Bioactive Compounds and Chronic Liver Diseases"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 25 April 2022.

Special Issue Editor

Dr. Anna Alisi
E-Mail Website
Guest Editor
Bambino Gesù Children’s Hospital and IRCCS, Research Area of Multifactorial Diseases, Viale San Paolo 15, 00146 Rome, Italy
Interests: liver diseases; non-alcoholic fatty liver disease; hepatocellular carcinoma; epigenetic mechanisms; microRNAs
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Special Issue Information

Dear Colleagues,

Food bioactive compounds are natural components generally present in small quantities in foods and possess biological activity in addition to having nutritional value. Most of these food bioactive compounds are present in small quantities in a variety of foods, including fruits, vegetables, cereals, oilseeds, and oils. These bioactive compounds are currently being intensively studied in order to evaluate their effects on health and enhance their biological activity on specific organs, such as the liver.

In this Special Issue, we will discuss the impact of bioactive compounds in foods on the development, prevention, and treatment of chronic liver diseases through original research articles, reviews, and editorials.

Potential issues may include but are not limited to interventional studies on the effect of different classes of bioactive compound (polyphenolic compounds, carotenoids, tocopherols, phytosterols, and organosulfur compounds) on human chronic liver diseases. These include diseases primarily affecting the liver such as chronic hepatitis, fibrosis, cirrhosis, alcoholic and nonalcoholic fatty liver, hepatocellular carcinoma, diseases caused by the immune system, and inherited conditions.

Particular attention will be also given in defining the role of food bioactive compounds in reducing the risk of major chronic liver diseases and the underlying biological mechanisms that account for these effects in in vitro and in vivo experimental models.

Dr. Anna Alisi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polyphenols
  • carotenoids
  • tocopherols
  • phytosterols
  • bioactive compounds
  • liver diseases
  • fatty liver
  • hepatocellular carcinoma
  • liver fibrosis
  • cholestasis

Published Papers (2 papers)

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Research

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Article
Chlorogenic Acid Protects against Advanced Alcoholic Steatohepatitis in Rats via Modulation of Redox Homeostasis, Inflammation, and Lipogenesis
Nutrients 2021, 13(11), 4155; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13114155 - 20 Nov 2021
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Abstract
The aim of this study was to evaluate the therapeutic effects of chlorogenic acid (CGA) in rats with advanced alcoholic steatohepatitis. The rats were fed on a high-fat diet and gavaged with ethanol (4 g/kg) for 8 weeks. The livers of ethanol-treated rats [...] Read more.
The aim of this study was to evaluate the therapeutic effects of chlorogenic acid (CGA) in rats with advanced alcoholic steatohepatitis. The rats were fed on a high-fat diet and gavaged with ethanol (4 g/kg) for 8 weeks. The livers of ethanol-treated rats showed steatosis; necrosis and mononuclear infiltration; and significant upregulation of the mRNA expression of the prooxidant (Cyp2e1, iNos), lipogenic (Srebp1, Acc), proinflammatory (Tlr4, Nf-κb, TnfA, Il-1B, and Il-6), and profibrogenic (TgfB, Col1, VegfA) genes. Simultaneously, a downregulation of level of Sod and Nrf2 was observed, which was accompanied by increased serum transaminase, TnfA, and serum and liver triglycerides levels. CGA administration (40 and 80 mg/kg, 8 weeks) to ethanol-fed group reduced the liver expression levels of Cyp2e1 and iNos, whereas it markedly enhanced the expression of Sod, Nrf2, and Ho-1. CGA at both doses downregulated the expressions of lipogenic, proinflammatory, and profibrogenic genes, while the expression of Tlr4 was lowered only after the higher dose of CGA. The higher dose of CGA efficiently prevented the progression of alcohol-induced steatosis and reduced inflammation through regulation of the expression of genes encoding the proteins involved in the Tlr4/Nf-κB signaling pathway and fibrosis. The study revealed hepatoprotective and anti-inflammatory effects of CGA through the regulation of expression of genes encoding Cyp2e1/Nrf2 involved in oxidative stress modulation. These results demonstrate CGA as a therapeutic candidate for the prevention and treatment of alcoholic steatohepatitis. Full article
(This article belongs to the Special Issue Food Bioactive Compounds and Chronic Liver Diseases)
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Review

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Review
Curcumin and Biochemical Parameters in Metabolic-Associated Fatty Liver Disease (MAFLD)—A Review
Nutrients 2021, 13(8), 2654; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13082654 - 30 Jul 2021
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Abstract
Metabolic-associated fatty liver disease (MAFLD), formerly non-alcoholic fatty liver disease (NAFLD), is characterized by excessive fat accumulation in hepatocytes. It is the most common chronic liver disease worldwide and is a significant public health problem. In the absence of pharmacological therapy, other treatments [...] Read more.
Metabolic-associated fatty liver disease (MAFLD), formerly non-alcoholic fatty liver disease (NAFLD), is characterized by excessive fat accumulation in hepatocytes. It is the most common chronic liver disease worldwide and is a significant public health problem. In the absence of pharmacological therapy, other treatments such as diet, physical activity, or supplementation are sought. Non-pharmacological therapies may include curcumin supplementation, which has been shown to have many health-promoting properties, including antioxidant, anti-inflammatory, and anti-cancer effects. For this reason, we reviewed available databases to analyze publications describing the effect of curcumin supplementation on biochemical parameters in MAFLD. Nine studies (eight RCTs and one CT) based solely on supplementation of patients with curcumin were included in this review. The results from the individual trials were varied and did not allow clear conclusions. Although they suggest that curcumin shows some potential in the treatment of MAFLD, further research is needed. Full article
(This article belongs to the Special Issue Food Bioactive Compounds and Chronic Liver Diseases)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Oleuropein prevents liver damage in NAFL mice by modulating copper-catalyzed dicarbonyl stress
Authors: Clara Balsano
Affiliation: Direttore Sc. di Spec. in Medicina d’Emergenza- Urgenza, Università del’Aquila, Via G. Petrini, Edificio Delta 6– Coppito, 67100 L'Aquila,Italy

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