Special Issue "Natural Food Ingredients for Human Health: New Insights from a Metabolic Perspective"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 20 December 2021.

Special Issue Editors

Dr. Leixuri Aguirre
E-Mail Website
Guest Editor
1. Nutrition and Obesity Group, Department of Pharmacy and Food Sciences, University of the Basque Country (UPV/EHU) and Lucio Lascaray Research Institute, Vitoria, Spain
2. CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain
Interests: polyphenols; polyphenol bioavailability; polyphenol metabolites; resveratrol; quercetin; NAFLD; obesity; type 2 diabetes
Dr. Itziar Eseberri
E-Mail Website
Guest Editor
1. Nutrition and Obesity Group, Department of Pharmacy and Food Sciences, University of the Basque Country (UPV/EHU) and Lucio Lascaray Research Institute, Vitoria, Spain
2. CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain
Interests: polyphenols; polyphenol bioavailability; polyphenol metabolites; resveratrol; quercetin; NAFLD; obesity; type 2 diabetes

Special Issue Information

Dear Colleagues,

In recent years, great attention has been paid to natural food ingredients due to their positive effects on health. Some ingredients, such as vitamins, minerals, polyphenols, probiotics, prebiotics and omega 3, among others, are naturally present in foodstuffs. They show beneficial effects on various physiological and biochemical processes, and thus, their use represents a potential tool for the prevention or treatment of highly prevalent diseases in our society, such as cardiovascular diseases, obesity, cancer or diabetes, among others. Although several beneficial effects have been described for human beings, others have only been established in preclinical studies so far. Furthermore, generally, not all key aspects are already well known. For these and other reasons, it is mandatory to continue with scientific research in this field. Indeed, new knowledge concerning these issues could enable the development of novel functional foods or nutraceuticals incorporating these ingredients, which should be suitable for preventing or treating several important diseases.

It is our great pleasure to invite researchers to provide manuscripts either describing original research or providing an up-to-date review of the scientific literature for a Special Issue of Nutrients on “Natural Food Ingredients for Human Health: New Insights from a Metabolic Perspective”. Very welcome will be manuscripts that present recent advances in the knowledge on natural food ingredients’ effects on health, including but not limited to the better understanding of their mechanisms of action, dose-response patterns, bioavailability enhancement strategies, and the study of population-group specific effects, among others.

Dr. Leixuri Aguirre
Dr. Itziar Eseberri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Bioactive compounds
  • Benefits on health
  • Cardiovascular diseases
  • Cancer
  • Obesity
  • Diabetes
  • Mechanisms of action
  • Bioavailability
  • Dose-response
  • Additive effects

Published Papers (1 paper)

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Research

Article
Trans-ε-Viniferin Encapsulation in Multi-Lamellar Liposomes: Consequences on Pharmacological Parameters, Biodistribution and Glucuronide Formation in Rats
Nutrients 2021, 13(12), 4212; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13124212 (registering DOI) - 24 Nov 2021
Viewed by 243
Abstract
Trans-ε-viniferin (εVin) is a resveratrol dimer exhibiting promising biological activities for human health. Its bioavailability being low, the development of encapsulation methods would be used to overcome this issue. The aim of this study was to measure the consequences of the encapsulation [...] Read more.
Trans-ε-viniferin (εVin) is a resveratrol dimer exhibiting promising biological activities for human health. Its bioavailability being low, the development of encapsulation methods would be used to overcome this issue. The aim of this study was to measure the consequences of the encapsulation of εVin in multilamellar liposomes on its pharmacokinetic parameters, metabolism and tissue distribution in rats. After oral administration of εVin (20 mg/kg body weight), either as free or encapsulated forms, plasmas were sequentially collected (from 0 to 4 h) as well as liver, kidneys and adipose tissues (4 h after administration) and analyzed by LC-HRMS. The glucuronide metabolites (εVG) were also produced by hemisynthesis for their quantification in plasma and tissues. The encapsulation process did not significantly modify the pharmacokinetic parameters of εVin itself. However, a significant increase of the T1/2 was noticed for εVG after administration of the encapsulated form as compared to the free form. An accumulation of εVin and εVG in adipose tissues was noticed, and interestingly a significant increase of the latter in the mesenteric one after administration of the encapsulated form was highlighted. Since adipose tissues could represent storage depots, and encapsulation allows for prolonging the exposure time of glucuronide metabolites in the organism, this could be of interest to promote their potential biological activities. Full article
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