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Dietary Methyl Donors and Epigenetics during Lifecycle

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: closed (29 February 2020) | Viewed by 17665

Special Issue Editor


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Guest Editor
Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Building 57, D-66424 Homburg, Germany
Interests: one-carbon metabolism; folate; B-vitamins; choline; methylation; epigenetics; maternal nutrition; cancer nutrition; nutrition epidemiology; public health nutrition; nutritional biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue in Nutrients will focus on the role of dietary methyl donors in epigenetics and during the lifecycle. You and your co-workers are kindly invited to contribute to this Special Issue with relevant articles. We encourage topics related to intake of methyl donors, genetics and epigenetics, and, in particular, studies addressing common disease conditions in vulnerable groups, such as pregnant women, infants, or the elderly population.

Potential topics may include, but are not limited to, the following:

The role of methyl donors (status markers or intake):

  • Epigenetics of birth defects, cancer, vascular diseases, dementia, or osteoporosis;
  • Child outcomes, such as physical growth, neurodevelopment, or asthma;
  • Obesity;
  • Fetal and maternal health;
  • Liver disorders;
  • Cognitive decline with aging;
  • Osteoporosis and hip fracture.

We welcome RCTs, epidemiological studies, meta-analyses, classical reviews, and expert opinions.

Please contact me or the Editorial Office if you feel that your intended topic fits within the scope of this Special Issue.

I encourage all authors to discuss the impact of their results on future studies, and to specify gaps in knowledge that would be necessary to solve in the following years.

I welcome your proposed publication title along with 3–6 explanatory sentences (max. 150 words) until 30 September 2019. The final deadline for submitting articles is 29 February 2020. All articles will be peer reviewed, and articles received before the deadline will be immediately processed and published online.

It would be a great pleasure to have you be part of this Special Issue.

Prof. Dr. Rima Obeid
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • choline
  • folate
  • betaine
  • methylation
  • epigenetics
  • infancy
  • pregnancy
  • obesity
  • dementia
  • elderly
  • cancer
  • osteoporosis
  • deficiency

Published Papers (2 papers)

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Review

20 pages, 2393 KiB  
Review
Vitamin B Supplementation and Nutritional Intake of Methyl Donors in Patients with Chronic Kidney Disease: A Critical Review of the Impact on Epigenetic Machinery
by Maria Cappuccilli, Camilla Bergamini, Floriana A. Giacomelli, Giuseppe Cianciolo, Gabriele Donati, Diletta Conte, Teresa Natali, Gaetano La Manna and Irene Capelli
Nutrients 2020, 12(5), 1234; https://0-doi-org.brum.beds.ac.uk/10.3390/nu12051234 - 27 Apr 2020
Cited by 12 | Viewed by 5115
Abstract
Cardiovascular morbidity and mortality are several-fold higher in patients with advanced chronic kidney disease (CKD) and end-stage renal disease (ESRD) than in the general population. Hyperhomocysteinemia has undoubtedly a central role in such a prominent cardiovascular burden. The levels of homocysteine are regulated [...] Read more.
Cardiovascular morbidity and mortality are several-fold higher in patients with advanced chronic kidney disease (CKD) and end-stage renal disease (ESRD) than in the general population. Hyperhomocysteinemia has undoubtedly a central role in such a prominent cardiovascular burden. The levels of homocysteine are regulated by methyl donors (folate, methionine, choline, betaine), and cofactors (vitamin B6, vitamin B12,). Uremia-induced hyperhomocysteinemia has as its main targets DNA methyltransferases, and this leads to an altered epigenetic control of genes regulated through methylation. In renal patients, the epigenetic landscape is strictly correlated with the uremic phenotype and dependent on dietary intake of micronutrients, inflammation, gut microbiome, inflammatory status, oxidative stress, and lifestyle habits. All these factors are key contributors in methylome maintenance and in the modulation of gene transcription through DNA hypo- or hypermethylation in CKD. This is an overview of the epigenetic changes related to DNA methylation in patients with advanced CKD and ESRD. We explored the currently available data on the molecular dysregulations resulting from altered gene expression in uremia. Special attention was paid to the efficacy of B-vitamins supplementation and dietary intake of methyl donors on homocysteine lowering and cardiovascular protection. Full article
(This article belongs to the Special Issue Dietary Methyl Donors and Epigenetics during Lifecycle)
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14 pages, 629 KiB  
Review
Methionine Restriction and Cancer Biology
by Desiree Wanders, Katherine Hobson and Xiangming Ji
Nutrients 2020, 12(3), 684; https://0-doi-org.brum.beds.ac.uk/10.3390/nu12030684 - 03 Mar 2020
Cited by 98 | Viewed by 12210
Abstract
The essential amino acid, methionine, is important for cancer cell growth and metabolism. A growing body of evidence indicates that methionine restriction inhibits cancer cell growth and may enhance the efficacy of chemotherapeutic agents. This review summarizes the efficacy and mechanism of action [...] Read more.
The essential amino acid, methionine, is important for cancer cell growth and metabolism. A growing body of evidence indicates that methionine restriction inhibits cancer cell growth and may enhance the efficacy of chemotherapeutic agents. This review summarizes the efficacy and mechanism of action of methionine restriction on hallmarks of cancer in vitro and in vivo. The review highlights the role of glutathione formation, polyamine synthesis, and methyl group donation as mediators of the effects of methionine restriction on cancer biology. The translational potential of the use of methionine restriction as a personalized nutritional approach for the treatment of patients with cancer is also discussed. Full article
(This article belongs to the Special Issue Dietary Methyl Donors and Epigenetics during Lifecycle)
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