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Non- and Low-Polar Phytonutrients—Preventive Potential

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (15 January 2021) | Viewed by 8425

Special Issue Editors

Department of Food Science and Dietetics, Wroclaw Medical University, 50-556 Wrocław, Poland
Interests: xenobiotics; oxidative stress; dietary factors in health and disease; bioactive lipid compounds; nutritional assessment
Special Issues, Collections and Topics in MDPI journals
Department of Pharmaceutical Biology and Biotechnology, Wroclaw Medical University, Wrocław, Poland
Interests: bioactive natural products; terpenoids; natural antioxidants

Special Issue Information

Dear Colleagues,

A diet rich in products of plant origin is now becoming the most favored eating pattern, with a proven potential to promote health. The protective role of plant-based nutrition is attributable to a variety of bioactive components, among them many kinds of non- and low-polar substances. Foods rich in lipophilic nutrients, such as oils, nuts, and seeds, attract a great amount of attention because of their diverse health benefits. In addition to having a nutritional value, lipophilic compounds can act as antioxidant, anti-inflammatory, and chemopreventive agents. Vegetable oils are predominantly composed of unsaturated fatty acids, mainly oleic acid and essential linoleic and α-linolenic acids, the intake of which is beneficial for cardiovascular risk reduction. The category of non- and low-polar phytonutrients also includes less abundant fatty acids, such as γ-linolenic, stearidonic, conjugated linolenic acid isomers, tocochromanols, carotenoids, sterols, volatile terpenoids, and phenolic compounds with low water solubility. The latter include, for example, flavonoid and stilbene aglycons, especially those substituted with less polar moieties such as methoxyl or prenyl groups, as well as curcuminoids and alkylresorcinols. As the health benefits of ingesting lipophilic plant compounds become more evident, numerous technologies have been developed to improve their stability and oral bioavailability.

This Special Issue on “Non- and Low-Polar Phytonutrients—Preventive Potential” will cover original research papers or reviews exploring associations between dietary lipophilic compounds of plant origin and health maintenance.

Dr. Anna Prescha
Prof. Dr. Adam Matkowski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Bioactive lipids
  • Fatty acids
  • Tocopherols
  • Phytosterols
  • Carotenoids
  • Terpenoids
  • Lipophilic phenolics
  • Disease prevention
  • Dietary intake

Published Papers (3 papers)

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15 pages, 4400 KiB  
Article
The Nutraceutical N-Palmitoylethanolamide (PEA) Reveals Widespread Molecular Effects Unmasking New Therapeutic Targets in Murine Varicocele
by Pietro Antonuccio, Herbert Ryan Marini, Antonio Micali, Carmelo Romeo, Roberta Granese, Annalisa Retto, Antonia Martino, Salvatore Benvenga, Salvatore Cuzzocrea, Daniela Impellizzeri, Rosanna Di Paola, Roberta Fusco, Raimondo Maximilian Cervellione and Letteria Minutoli
Nutrients 2021, 13(3), 734; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13030734 - 25 Feb 2021
Cited by 10 | Viewed by 2645 | Correction
Abstract
Varicocele is an age-related disease with no current medical treatments positively impacting infertility. Toll-like receptor 4 (TLR4) expression is present in normal testis with an involvement in the immunological reactions. The role of peroxisome proliferator-activated receptor-α (PPAR-α), a nuclear receptor, in fertility is [...] Read more.
Varicocele is an age-related disease with no current medical treatments positively impacting infertility. Toll-like receptor 4 (TLR4) expression is present in normal testis with an involvement in the immunological reactions. The role of peroxisome proliferator-activated receptor-α (PPAR-α), a nuclear receptor, in fertility is still unclear. N-Palmitoylethanolamide (PEA), an emerging nutraceutical compound present in plants and animal foods, is an endogenous PPAR-α agonist with well-demonstrated anti-inflammatory and analgesics characteristics. In this model of mice varicocele, PPAR-α and TLR4 receptors’ roles were investigated through the administration of ultra-micronized PEA (PEA-um). Male wild-type (WT), PPAR-α knockout (KO), and TLR4 KO mice were used. A group underwent sham operation and administration of vehicle or PEA-um (10 mg/kg i.p.) for 21 days. Another group (WT, PPAR-α KO, and TLR4 KO) underwent surgical varicocele and was treated with vehicle or PEA-um (10 mg/kg i.p.) for 21 days. At the end of treatments, all animals were euthanized. Both operated and contralateral testes were processed for histological and morphometric assessment, for PPAR-α, TLR4, occludin, and claudin-11 immunohistochemistry and for PPAR-α, TLR4, transforming growth factor-beta3 (TGF-β3), phospho-extracellular signal-Regulated-Kinase (p-ERK) 1/2, and nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) Western blot analysis. Collectively, our data showed that administration of PEA-um revealed a key role of PPAR-α and TLR4 in varicocele pathophysiology, unmasking new nutraceutical therapeutic targets for future varicocele research and supporting surgical management of male infertility. Full article
(This article belongs to the Special Issue Non- and Low-Polar Phytonutrients—Preventive Potential)
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11 pages, 1925 KiB  
Article
The Effects of Brown Algae-Derived Monosaccharide L-Fucose on Lipid Metabolism in C57BL/6J Obese Mice
by Xiao Yuan, Tomohiko Nakao, Hina Satone, Kazuyuki Ohara, Yuri Kominami, Miho Ito, Teruki Aizawa, Tomoya Ueno and Hideki Ushio
Nutrients 2020, 12(12), 3798; https://0-doi-org.brum.beds.ac.uk/10.3390/nu12123798 - 11 Dec 2020
Cited by 8 | Viewed by 4664
Abstract
Obesity is a global public health problem and a risk factor for several metabolic disorders as well as cancer. In this study, we investigated the effects of L-fucose on lipid metabolism through chronic and acute in vivo experiments in mice. In the chronic [...] Read more.
Obesity is a global public health problem and a risk factor for several metabolic disorders as well as cancer. In this study, we investigated the effects of L-fucose on lipid metabolism through chronic and acute in vivo experiments in mice. In the chronic test, mice were fed a high-calorie diet (HCD) containing 0.0001%, 0.001%, 0.01%, and 0.1% L-fucose for one month. The L-fucose supplementation inhibited body weight and visceral fat mass gain in HCD-fed mice. The results of the acute test showed that L-fucose increased the ratio of serum high molecular weight adiponectin and enhanced glucose and lipid catabolism. Furthermore, L-fucose also decreased the expression of adipogenic genes (peroxisome proliferator-activated receptor γ and cluster of differentiation 36). In conclusion, this study provides a new approach to combat obesity and the related diseases. Full article
(This article belongs to the Special Issue Non- and Low-Polar Phytonutrients—Preventive Potential)
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3 pages, 28020 KiB  
Correction
Correction: Antonuccio et al. The Nutraceutical N-Palmitoylethanolamide (PEA) Reveals Widespread Molecular Effects Unmasking New Therapeutic Targets in Murine Varicocele. Nutrients 2021, 13, 734
by Pietro Antonuccio, Herbert Ryan Marini, Antonio Micali, Carmelo Romeo, Roberta Granese, Annalisa Retto, Antonia Martino, Salvatore Benvenga, Salvatore Cuzzocrea, Daniela Impellizzeri, Rosanna Di Paola, Roberta Fusco, Raimondo Maximilian Cervellione and Letteria Minutoli
Nutrients 2023, 15(7), 1662; https://0-doi-org.brum.beds.ac.uk/10.3390/nu15071662 - 29 Mar 2023
Viewed by 634
Abstract
In the original publication [...] Full article
(This article belongs to the Special Issue Non- and Low-Polar Phytonutrients—Preventive Potential)
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