Special Issue "Role of Nutraceuticals in Oxidative Stress and Inflammation Linked to Cardiometabolic Disorders"
Deadline for manuscript submissions: 10 January 2022.
Interests: cardiovascular system, gut, biosensors, natural compounds, oxidative damage
Special Issues, Collections and Topics in MDPI journals
Interests: signal transduction; autophagy; apoptosis and senescence in relation to cardiovascular diseases; epigenetic changes; role of microRNA; nutritional elements and bioactive components in foods
Despite the efforts toward primary prevention, cardiovascular diseases are still the most common causes of death and one of the first causes of disability in industrialized countries. Current opinions with respect to the etiology of cardiovascular diseases are still controversial. There are multiple factors involved, such as inflammation, vascular smooth muscle cell (VSMC) proliferation, endothelial cells dysfunctions (EC), macrophage differentiation, and oxidative stress. Oxidative stress that results from the imbalance between reactive oxygen species and antioxidants is a one of the key factors; indeed, experimental and clinical evidence supports the casual relationship between oxidative stress and various cardiovascular diseases. Thus, numerous studies are focused on ameliorating these types of chronic diseases by reducing oxidative stress.
A relatively large number of dietary supplements, nutraceuticals, phytochemicals, and functional foods have been studied for their ability to improve blood lipid profile in humans and to protect cells from oxidative stress and from damages related to inflammatory conditions. The scientific community has recognized their effectiveness since 2001, when during the third National Cholesterol Educational Program, it was suggested to integrate dietary supplements such as soluble fibers, omega-3 polyunsaturated fatty acids (PUFAs), plant sterols, and soy protein into the diet in order to achieve an optimal low density lipoprotein–cholesterol (LDL-C) level. Similarly, in the new European guidelines for the management of dyslipidemias (Catapano et al. “ESC/EAS Guidelines for the management of dyslipidaemias. The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS).” Atherosclerosis, 2011, 217(1), 3-46), some nutraceuticals were added as potentially useful for lipid-lowering agents. Since the prevention of cardiometabolic disorders needs an everyday approach, both the tolerability and safety of dietary supplements, either nutraceuticals or botanicals, have to be adequately defined, as well as understanding the precise mechanisms of action and the risk/benefit ratio related to their assumption.
In this Special Issue, we invite investigators to contribute original research articles reporting data from both experimental and clinical studies, as well as review articles, which provide a better understanding of the effects of nutraceuticals, dietary supplements, phytochemicals, and functional foods on cardiovascular diseases linked to oxidative stress and inflammation. Potential topics include but are not limited to the following:
- Evaluation, by in vitro or in vivo studies, of the safety and the cellular and molecular mechanisms underlying the actions of natural compounds in relation to ROS-mediated signaling and redox modulation, inflammation, and endothelial dysfunction;
- Evaluation of biomarkers of cardiometabolic health, by bioanalytical methods and biosensors for the determination of the biological effects of these substances;
- Nutraceuticals, new formulations or specific diets as therapeutic strategies;
- Nutrigenetics, nutrigenomics, and potential effect on the intestinal microbiome.Dr. Cristiana Caliceti
Dr. Silvia Cetrullo
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.