Special Issue "Nutrition and Exercise Influences on Oxylipins"
A special issue of Nutrients (ISSN 2072-6643).
Deadline for manuscript submissions: closed (4 November 2019).
2. Director of the Human Performance Laboratory,North Carolina Research Campus,Kannapolis, NC 28081, USA
Interests: sports nutrition; exercise; immunology; inflammation; obesity; metabolomics; proteomics; lipid mediators
Special Issues and Collections in MDPI journals
Special Issue in Nutrients: Influence of Carbohydrate and Phytochemical Ingestion on Exercise-Induced Immune Dysfunction, Inflammation, Muscle Damage, Oxidative Stress, and Metabolic Recovery
Special Issue in Nutrients: Influence of Carbohydrates Intake on Inflammation
Special Issue in Nutrients: Sports Nutrition
Special Issue in Metabolites: Sports and Health Metabolism
Special Issue in Nutrients: Selected Papers from the 2nd International Electronic Conference on Nutrients - Nutrition Support for Immunity and Countermeasure Effects on Infection, Inflammation, and Oxidative Stress
Oxylipins are bioactive oxidation products derived from n-6 and n-3 polyunsaturated fatty acids (PUFAs) in the linoleic acid and α-linolenic desaturation pathways. Due to their potency, oxylipins are not stored but are instead synthesized de novo in a tightly regulated manner. Membrane phospholipid PUFAs are first released by phospholipase A2 (PLA2) in response to cell activation from various stress-related stimuli including injury and inflammation. Cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) enzyme systems metabolize the released PUFAs into numerous diverse oxylipins that act as autocrine and paracrine lipid mediators by binding to cell surface G protein-coupled receptors or to multiple intracellular and nuclear receptors, such as peroxisome proliferator-activated receptor-γ (PPAR-γ).
Recent advances in mass spectrometry equipment and analytical capacities have increased the awareness of the vital regulatory roles of oxylipins in numerous physiological processes including cardiac function, vascular tone, blood coagulation, innate immune function, and inflammation. The influences of diet interventions, exercise training, obesity, and various disease states on oxylipin generation represent an emerging field of scientific endeavor. There is a growing awareness that metabolic, lifestyle, environmental, and physiological stresses can turn oxylipins from beneficial signaling agents into mediators of immune dysfunction, chronic inflammation, and other unfavorable responses.
This Special Issue of Nutrients will focus on the effects of nutrition, exercise, obesity, and related lifestyle factors on oxylipins. Researchers are invited to submit insightful reviews and original research papers in this area of metabolism.
Prof. Dr. David C. Nieman
Manuscript Submission Information
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- polyunsaturated fatty acids
- immune dysfunction