Special Issue "Nutrition and Exercise Influences on Oxylipins"

A special issue of Nutrients (ISSN 2072-6643).

Deadline for manuscript submissions: closed (4 November 2019).

Special Issue Editor

Prof. Dr. David C. Nieman
E-Mail Website
Guest Editor

Special Issue Information

Dear Colleagues,

Oxylipins are bioactive oxidation products derived from n-6 and n-3 polyunsaturated fatty acids (PUFAs) in the linoleic acid and α-linolenic desaturation pathways. Due to their potency, oxylipins are not stored but are instead synthesized de novo in a tightly regulated manner. Membrane phospholipid PUFAs are first released by phospholipase A2 (PLA2) in response to cell activation from various stress-related stimuli including injury and inflammation. Cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) enzyme systems metabolize the released PUFAs into numerous diverse oxylipins that act as autocrine and paracrine lipid mediators by binding to cell surface G protein-coupled receptors or to multiple intracellular and nuclear receptors, such as peroxisome proliferator-activated receptor-γ (PPAR-γ).

Recent advances in mass spectrometry equipment and analytical capacities have increased the awareness of the vital regulatory roles of oxylipins in numerous physiological processes including cardiac function, vascular tone, blood coagulation, innate immune function, and inflammation. The influences of diet interventions, exercise training, obesity, and various disease states on oxylipin generation represent an emerging field of scientific endeavor. There is a growing awareness that metabolic, lifestyle, environmental, and physiological stresses can turn oxylipins from beneficial signaling agents into mediators of immune dysfunction, chronic inflammation, and other unfavorable responses.

This Special Issue of Nutrients will focus on the effects of nutrition, exercise, obesity, and related lifestyle factors on oxylipins. Researchers are invited to submit insightful reviews and original research papers in this area of metabolism.

Prof. Dr. David C. Nieman
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • oxylipins
  • nutrition
  • exercise
  • polyunsaturated fatty acids
  • obesity
  • inflammation
  • immune dysfunction

Published Papers

There is no accepted submissions to this special issue at this moment.
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