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Phytochemicals and Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 3956

Special Issue Editors

Food Bioscience Group, Department of Bioactivity and Food Analysis, Institute of Food Science Research (CIAL), Spanish National Research Council (CSIC), The Autonoma University of Madrid (UAM), Nicolás Cabrera 9, 28049 Madrid, Spain
Interests: bioactive compounds; diet; dietary fiber; food processing and health; food quality and safety; functional foods; human nutrition and health; novel ingredients and foods; food waste recovery into healthy ingredients
Special Issues, Collections and Topics in MDPI journals
1. Biofortis Research, Merieux Nutrisciences, Addison, IL, USA
2. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA
Interests: antioxidants; oxidative stress; polyphenols; flavonoids; glucoregulation; inflammation; tree nuts; berries; whole grains
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nutrients was launched in 2009 and has published over 10,000 papers since. With an impact factor of 4.171, Nutrients ranks as a Q1 journal and has become an excellent open source platform to ensure rapid and widespread exposure of your research findings and perspectives.

As the Section Editor of the newly established Phytochemicals and Human Health section, we personally invite you to submit a review paper in your specific area of expertise. This Special Issue aims to publish high-quality scientific contributions providing novel insights into the impact of dietary intake of plant ingredients, also called phytochemicals, on the physical, mental, and emotional health and wellbeing of humans.

Dr. Maria Dolores del Castillo
Dr. Oliver Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • phytochemicals
  • health promotion
  • wellbeing
  • digestibility
  • bioaccessibility
  • metabolism
  • absorption
  • mechanism of action
  • physiological functions
  • phytochemomics and toxicity

Published Papers (1 paper)

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Research

17 pages, 3929 KiB  
Article
Phenethyl Isothiocyanate Protects against High Fat/Cholesterol Diet-Induced Obesity and Atherosclerosis in C57BL/6 Mice
by Min-Hee Gwon, Young-Sun Im, A-Reum Seo, Kyoung Yun Kim, Ha-Rin Moon and Jung-Mi Yun
Nutrients 2020, 12(12), 3657; https://doi.org/10.3390/nu12123657 - 27 Nov 2020
Cited by 19 | Viewed by 3288
Abstract
This study concerns obesity-related atherosclerosis, hyperlipidemia, and chronic inflammation. We studied the anti-obesity and anti-atherosclerosis effects of phenethyl isothiocyanate (PEITC) and explored their underlying mechanisms. We established an animal model of high fat/cholesterol-induced obesity in C57BL/6 mice fed for 13 weeks. We divided [...] Read more.
This study concerns obesity-related atherosclerosis, hyperlipidemia, and chronic inflammation. We studied the anti-obesity and anti-atherosclerosis effects of phenethyl isothiocyanate (PEITC) and explored their underlying mechanisms. We established an animal model of high fat/cholesterol-induced obesity in C57BL/6 mice fed for 13 weeks. We divided the mice into five groups: control (CON), high fat/cholesterol (HFCD), HFCD with 3 mg/kg/day gallic acid (HFCD + G), and HFCD with PEITC (30 and 75 mg/kg/day; HFCD + P30 and P75). The body weight, total cholesterol, and triglyceride were significantly lower in the HFCD + P75 group than in the HFCD group. Hepatic lipid accumulation and atherosclerotic plaque formation in the aorta were significantly lower in both HFCD + PEITC groups than in the HFCD group, as revealed by hematoxylin and eosin (H&E) staining. To elucidate the mechanism, we identified the expression of genes related to inflammation, reverse cholesterol transport, and lipid accumulation pathway in the liver. The expression levels of peroxisome proliferator activated receptor gamma (PPARγ), liver-X-receptor α (LXR-α), and ATP binding cassette subfamily A member 1 (ABCA1) were increased, while those of scavenger receptor A (SR-A1), cluster of differentiation 36 (CD36), and nuclear factor-kappa B (NF-κB) were decreased in the HFCD + P75 group compared with those in the HFCD group. Moreover, PEITC modulated H3K9 and H3K27 acetylation, H3K4 dimethylation, and H3K27 di-/trimethylation in the HFCD + P75 group. We, therefore, suggest that supplementation with PEITC may be a potential candidate for the treatment and prevention of atherosclerosis and obesity. Full article
(This article belongs to the Special Issue Phytochemicals and Human Health)
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