Special Issue "Polyphenols and Cancer Prevention"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 15 April 2022.

Special Issue Editor

Dr. Sergio Granados-Principal
E-Mail Website
Guest Editor
Department of Medical Oncology, University Hospital of Jaen, Jaen, Spain
Interests: breast cancer; natural compounds; polyphenols; antioxidants; chemoprevention; cancer stem cells; chemotherapy; tumor resistance; metastasis; targeted therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polyphenols are a heterogeneous and abundant naturally occurring compounds which are present in a variety of plants, and their food derivatives, like vegetables, trees, fruits, whole grains, legumes, beverages, oils, nuts, algae, and even fungi. These bioactive molecules, and their metabolites, have been extensively addressed in research by their protective role against chronic diseases including cancer. Such ability of polyphenolic compounds on cancer prevention is attributed to a wide range of activities (including antioxidant capacity, modulation of numerous signaling pathways like TGFβ/SMADs, PI3K/Akt/mTOR, Wnt, or NF-κB, or interaction with microbiota) that promote genome stability, strengthen immune system, reduce inflammation, cell senescence, among other responses that positively influence in the prevention of cancer appearance.     

The topics of this special issue of Nutrients include, although not limited to, relevant research of plant polyphenols, as well as their metabolites, food derivatives, and extracts, on modulating (positively/negatively) the effects mediated by any factor that may promote or prevent cancer (environment, lifestyle, genetic predisposition…), including alterations on immune system, tissue microenvironment, and interaction with microbiota. Polyphenols from different origin, other than plants, will also be considered.   

Dr. Sergio Granados-Principal
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • polyphenols
  • metabolites 
  • bioactive compounds 
  • mediterranean diet
  • cancer prevention
  • risk factors 
  • immunomodulation
  • tissue microenvironment
  • microbiota

Published Papers

This special issue is now open for submission.
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