Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.0
5.9
Journals
Nutrients
Special Issues
Natural and Synthetic Bioactives for Skin Health, Disease and Management
nutrients-logo
Submit to Nutrients Review for Nutrients Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Natural and Synthetic Bioactives for Skin Health, Disease and Management

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (15 September 2021) | Viewed by 117414

Printed Edition Available!
A printed edition of this Special Issue is available here.

Special Issue Editors

Dr. Jean Christopher Chamcheu

E-Mail Website
Guest Editor
Department of Biological Sciences and Chemistry, College of Sciences and Engineering, Southern University and A&M College, Baton Rouge, LA 70807, USA
Interests: skin health and diseases; carcinogenesis; inflammation; dermatology; psoriasis; atopic dermatitis; bioactive natural products; antioxidants; polyphenols; flavonoids; tissue engineering; signaling pathways; pharmacology
Special Issues, Collections and Topics in MDPI journals
Dr. Anthony L. Walker

E-Mail Website
Guest Editor
School of Clinical Sciences, College of Pharmacy, University of Louisiana Monroe, 1800 Bienville Drive, Monroe, LA 71201, USA
Interests: pharmacy practice; laboratory pedagogy and teaching styles; pharmaceutical compounding; natural products and formulation; compounding novel dosage forms for drug delivery; pharmacy practice clinical; educational and natural product research; health screening in under-privileged communities
Special Issues, Collections and Topics in MDPI journals
Dr. Felicite Noubissi-Kamdem

E-Mail Website
Guest Editor
Department of Biology, College of Science Engineering and Technology, Jackson State University, 1400 JR Lynch St., Jackson, MS 39217, USA
Interests: molecular mechanisms of cancer development and metastasis; role of IGF2BP1 in the pathology of colorectal cancer and basal cell carcinoma; cancer cell fusion and breast tumor heterogeneity and metastasis; mRNA turnover and cancer development
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Being the largest organ of the human body, the skin serves several functions, including being a physical and immunologic barrier ensuring normal human wellbeing. Biologically active natural/plant-derived product preparations and synthetic scaffolds are garnering interest as valid human health-promoting, disease prevention, and management entities, both in the modern and alternative medicine arenas. Several of these bioactives regulate vital physiological processes, including gene expression, protein synthesis, metabolism, differentiation, and growth by mechanisms that are not well understood. Through epidemiological and intervention studies, several of these bioactives have been claimed and/or proven to offer skin protection against aging, environmental hazards, oxidative stress, infection and several chronic inflammatory diseases like acne, atopic dermatitis, psoriasis, diabetic ulcers, chronic wounds, various skin cancers, and several associated risk factors. Moreover, cutting-edge research utilizing physiologically attainable doses in appropriate in vitro and preclinical model systems has provided some mechanistic insights. Additionally, validating the beneficial effects in terms of skin health of nutraceuticals or pharmaceuticals and acquiring a detailed understanding of their intake, pharmacokinetic/pharmacodynamics, dose–response relationship, and efficacy are warranted.

The purpose of this Special Issue is to update knowledge vis-à-vis the role of bioactive natural dietary and synthetic compounds on healthy and diseased skin, including the breast, and to shed light on the global relevance of scientific research findings on their usages. This may range from skin health promotion and cosmetic tanning, disease prevention and treatment, to reduction of adverse side effects, misuse, and purposeless spending.

To help bridge the current knowledge gap, this Special Issue of Nutrients invites the submission of manuscripts describing original research, short communication, legislative documentations or quality reviews of scientific literature in skin health promotion and disease prevention and treatment. These conditions may include but not be limited to infection, environment/oxidative stress, chronic inflammatory skin diseases like acne, atopic dermatitis, psoriasis, diabetic wounds, and various kinds of skin and breast cancers. Submissions addressing a broad range of topics are welcome, including studies covering bioavailability, understanding physiological functional processes, molecular targets, pathways and mechanisms of action from in vitro, preclinical animal models, human population, and dietary intervention studies to impacts on skin health, disease prevention and management, and advice on intake/usage and their outcomes are welcome.

We look forward to your exciting submissions.

Assist. Prof. Dr. Jean Christopher Chamcheu
Assoc. Prof. Dr. Anthony L. Walker
Assist. Prof. Dr. Felicite Noubissi-Kamdem
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Acne, atopic dermatitis, and psoriasis
  • Antioxidants and phenolic compounds
  • Breast cancer
  • Bioavailability and bioactivity
  • Environmental factors and skin health
  • Skin beauty and biology
  • Skin aging and disease
  • Skin infection, immunity, and inflammation
  • Skin cancer
  • Skin care and wounds
  • Natural dietary bioactives and Food supplement
  • Nutraceuticals and synthetic bioactive products
  • Natural dietary products as alternative medicine
  • Natural/synthetic bioactive agents for chemoprevention
  • Nanoformulations and nanomedicine
  • Human intervention trials
  • Natural products, preclinical and clinical trials in skin health
  • Natural/synthetic Antimicrobials and immune-modulatory agents
  • Phytonutrients for human skin health and disease

Published Papers (19 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Editorial

Jump to: Research, Review

6 pages, 203 KiB  
Editorial
Natural and Synthetic Bioactives for Skin Health, Disease and Management
by Jean Christopher Chamcheu, Anthony Lynn. Walker and Felicite Kamdem Noubissi
Nutrients 2021, 13(12), 4383; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13124383 - 08 Dec 2021
Cited by 1 | Viewed by 2537
Abstract
The skin is the largest organ of the integumentary system, strategically located at the interface of the body’s internal and external environment. [...] Full article
(This article belongs to the Special Issue Natural and Synthetic Bioactives for Skin Health, Disease and Management)

Research

Jump to: Editorial, Review

21 pages, 7698 KiB  
Article
Lithospermum erythrorhizon Alleviates Atopic Dermatitis-like Skin Lesions by Restoring Immune Balance and Skin Barrier Function in 2.4-Dinitrochlorobenzene-Induced NC/Nga Mice
by Jin-Su Oh, Sang-Jun Lee and Se-Young Choung
Nutrients 2021, 13(9), 3209; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13093209 - 15 Sep 2021
Cited by 10 | Viewed by 6006
Abstract
The incidence of atopic dermatitis (AD), a disease characterized by an abnormal immune balance and skin barrier function, has increased rapidly in developed countries. This study investigated the anti-atopic effect of Lithospermum erythrorhizon (LE) using NC/Nga mice induced by 2,4-dinitrochlorobenzene. LE reduced AD [...] Read more.
The incidence of atopic dermatitis (AD), a disease characterized by an abnormal immune balance and skin barrier function, has increased rapidly in developed countries. This study investigated the anti-atopic effect of Lithospermum erythrorhizon (LE) using NC/Nga mice induced by 2,4-dinitrochlorobenzene. LE reduced AD clinical symptoms, including inflammatory cell infiltration, epidermal thickness, ear thickness, and scratching behavior, in the mice. Additionally, LE reduced serum IgE and histamine levels, and restored the T helper (Th) 1/Th2 immune balance through regulation of the IgG1/IgG2a ratio. LE also reduced the levels of AD-related cytokines and chemokines, including interleukin (IL)-1β, IL-4, IL-6, tumor necrosis factor-α (TNF-α), thymic stromal lymphopoietin, thymus and activation-regulated chemokine, macrophage-derived chemokine, regulated on activation, normal T cell expressed and secreted, and monocyte chemoattractant protein-1 in the serum. Moreover, LE modulated AD-related cytokines and chemokines expressed and secreted by Th1, Th2, Th17, and Th22 cells in the dorsal skin and splenocytes. Furthermore, LE restored skin barrier function by increasing pro-filaggrin gene expression and levels of skin barrier-related proteins filaggrin, involucrin, loricrin, occludin, and zonula occludens-1. These results suggest that LE is a potential therapeutic agent that can alleviate AD by modulating Th1/Th2 immune balance and restoring skin barrier function. Full article
(This article belongs to the Special Issue Natural and Synthetic Bioactives for Skin Health, Disease and Management)
►▼ Show Figures

Graphical abstract

13 pages, 1747 KiB  
Article
Effects of Eggshell Membrane on Keratinocyte Differentiation and Skin Aging In Vitro and In Vivo
by Kyohei Furukawa, Masaya Kono, Tetsuro Kataoka, Yukio Hasebe, Huijuan Jia and Hisanori Kato
Nutrients 2021, 13(7), 2144; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13072144 - 22 Jun 2021
Cited by 7 | Viewed by 4397
Abstract
Skin aging is one of the hallmarks of the aging process that causes physiological and morphological changes. Recently, several nutritional studies were conducted to delay or suppress the aging process. This study investigated whether nutritional supplementation of the eggshell membrane (ESM) has a [...] Read more.
Skin aging is one of the hallmarks of the aging process that causes physiological and morphological changes. Recently, several nutritional studies were conducted to delay or suppress the aging process. This study investigated whether nutritional supplementation of the eggshell membrane (ESM) has a beneficial effect on maintaining skin health and improving the skin aging process in vitro using neonatal normal human epidermal keratinocytes (NHEK-Neo) and in vivo using interleukin-10 knockout (IL-10 KO) mice. In NHEK-Neo cells, 1 mg/mL of enzymatically hydrolyzed ESM (eESM) upregulated the expression of keratinocyte differentiation markers, including keratin 1, filaggrin and involucrin, and changed the keratinocyte morphology. In IL-10 KO mice, oral supplementation of 8% powdered-ESM (pESM) upregulated the expression of growth factors, including transforming growth factor β1, platelet-derived growth factor-β and connective tissue growth factor, and suppressed skin thinning. Furthermore, voltage-gated calcium channel, transient receptor potential cation channel subfamily V members were upregulated by eESM treatment in NHEK-Neo cells and pESM supplementation in IL-10 KO mice. Collectively, these data suggest that ESM has an important role in improving skin health and aging, possibly via upregulating calcium signaling. Full article
(This article belongs to the Special Issue Natural and Synthetic Bioactives for Skin Health, Disease and Management)
►▼ Show Figures

Graphical abstract

15 pages, 1685 KiB  
Article
Effects of Lactobacillus plantarum CJLP55 on Clinical Improvement, Skin Condition and Urine Bacterial Extracellular Vesicles in Patients with Acne Vulgaris: A Randomized, Double-Blind, Placebo-Controlled Study
by Mi-Ju Kim, Kun-Pyo Kim, Eunhye Choi, June-Hyuck Yim, Chunpil Choi, Hyun-Sun Yun, Hee-Yoon Ahn, Ji-Young Oh and Yunhi Cho
Nutrients 2021, 13(4), 1368; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13041368 - 19 Apr 2021
Cited by 22 | Viewed by 6233
Abstract
Lactobacillus plantarum CJLP55 has anti-pathogenic bacterial and anti-inflammatory activities in vitro. We investigated the dietary effect of CJLP55 supplement in patients with acne vulgaris, a prevalent inflammatory skin condition. Subjects ingested CJLP55 or placebo (n = 14 per group) supplements for 12 [...] Read more.
Lactobacillus plantarum CJLP55 has anti-pathogenic bacterial and anti-inflammatory activities in vitro. We investigated the dietary effect of CJLP55 supplement in patients with acne vulgaris, a prevalent inflammatory skin condition. Subjects ingested CJLP55 or placebo (n = 14 per group) supplements for 12 weeks in this double-blind, placebo-controlled randomized study. Acne lesion count and grade, skin sebum, hydration, pH and surface lipids were assessed. Metagenomic DNA analysis was performed on urine extracellular vesicles (EV), which indirectly reflect systemic bacterial flora. Compared to the placebo supplement, CJLP55 supplement improved acne lesion count and grade, decreased sebum triglycerides (TG), and increased hydration and ceramide 2, the major ceramide species that maintains the epidermal lipid barrier for hydration. In addition, CJLP55 supplement decreased the prevalence of Proteobacteria and increased Firmicutes, which were correlated with decreased TG, the major skin surface lipid of sebum origin. CJLP55 supplement further decreased the Bacteroidetes:Firmicutes ratio, a relevant marker of bacterial dysbiosis. No differences in skin pH, other skin surface lipids or urine bacterial EV phylum were noted between CJLP55 and placebo supplements. Dietary Lactobacillus plantarum CJLP55 was beneficial to clinical state, skin sebum, and hydration and urine bacterial EV phylum flora in patients with acne vulgaris. Full article
(This article belongs to the Special Issue Natural and Synthetic Bioactives for Skin Health, Disease and Management)
►▼ Show Figures

Graphical abstract

13 pages, 3438 KiB  
Article
Perilla frutescens Extracts Enhance DNA Repair Response in UVB Damaged HaCaT Cells
by Hyuna Lee and Eunmi Park
Nutrients 2021, 13(4), 1263; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13041263 - 12 Apr 2021
Cited by 6 | Viewed by 3520
Abstract
Physiological processes in skin are associated with exposure to UV light and are essential for skin maintenance and regeneration. Here, we investigated whether the leaf and callus extracts of Perilla frutescens (Perilla), a well-known Asian herb, affect DNA damage response and repair [...] Read more.
Physiological processes in skin are associated with exposure to UV light and are essential for skin maintenance and regeneration. Here, we investigated whether the leaf and callus extracts of Perilla frutescens (Perilla), a well-known Asian herb, affect DNA damage response and repair in skin and keratinocytes exposed to Untraviolet B (UVB) light. First, we examined the protective effects of Perilla leaf extracts in UVB damaged mouse skin in vivo. Second, we cultured calluses using plant tissue culture technology, from Perilla leaf explant and then examined the effects of the leaf and callus extracts of Perilla on UVB exposed keratinocytes. HaCaT cells treated with leaf and callus Perilla extracts exhibited antioxidant activities, smaller DNA fragment tails, and enhanced colony formation after UVB exposure. Interestingly, keratinocytes treated with the leaf and callus extracts of Perilla showed G1/S cell cycle arrest, reduced protein levels of cyclin D1, Cyclin Dependent Kinase 6 (CDK6), and γH2AX, and enhanced levels of phosphorylated checkpoint kinase 1 (pCHK1) following UVB exposure. These observations suggest that the leaf and callus extracts of Perilla are candidate nutraceuticals for the prevention of keratinocyte aging. Full article
(This article belongs to the Special Issue Natural and Synthetic Bioactives for Skin Health, Disease and Management)
►▼ Show Figures

Figure 1

12 pages, 2621 KiB  
Article
Propolis Suppresses UV-Induced Photoaging in Human Skin through Directly Targeting Phosphoinositide 3-Kinase
by Da Hyun Kim, Joong-Hyuck Auh, Jeongyeon Oh, Seungpyo Hong, Sungbin Choi, Eun Ju Shin, Soon Ok Woo, Tae-Gyu Lim and Sanguine Byun
Nutrients 2020, 12(12), 3790; https://0-doi-org.brum.beds.ac.uk/10.3390/nu12123790 - 10 Dec 2020
Cited by 11 | Viewed by 4900
Abstract
Propolis is a resinous substance generated by bees using materials from various plant sources. It has been known to exhibit diverse bioactivities including anti-oxidative, anti-microbial, anti-inflammatory, and anti-cancer effects. However, the direct molecular target of propolis and its therapeutic potential against skin aging [...] Read more.
Propolis is a resinous substance generated by bees using materials from various plant sources. It has been known to exhibit diverse bioactivities including anti-oxidative, anti-microbial, anti-inflammatory, and anti-cancer effects. However, the direct molecular target of propolis and its therapeutic potential against skin aging in humans is not fully understood. Herein, we investigated the effect of propolis on ultraviolet (UV)-mediated skin aging and its underlying molecular mechanism. Propolis suppressed UV-induced matrix metalloproteinase (MMP)-1 production in human dermal fibroblasts. More importantly, propolis treatment reduced UV-induced MMP-1 expression and blocked collagen degradation in human skin tissues, suggesting that the anti-skin-aging activity of propolis can be recapitulated in clinically relevant conditions. While propolis treatment did not display any noticeable effects against extracellular signal-regulated kinase (ERK), p38, and c-jun N-terminal kinase (JNK) pathways, propolis exerted significant inhibitory activity specifically against phosphorylations of phosphoinositide-dependent protein kinase-1 (PDK1) and protein kinase B (Akt). Kinase assay results demonstrated that propolis can directly suppress phosphoinositide 3-kinase (PI3K) activity, with preferential selectivity towards PI3K with p110α and p110δ catalytic subunits over other kinases. The content of active compounds was quantified, and among the compounds identified from the propolis extract, caffeic acid phenethyl ester, quercetin, and apigenin were shown to attenuate PI3K activity. These results demonstrate that propolis shows anti-skin-aging effects through direct inhibition of PI3K activity. Full article
(This article belongs to the Special Issue Natural and Synthetic Bioactives for Skin Health, Disease and Management)
►▼ Show Figures

Figure 1

17 pages, 3313 KiB  
Article
Anti-Melanogenesis Effects of Lotus Seedpod In Vitro and In Vivo
by Jen-Ying Hsu, Hui-Hsuan Lin, Ting-Shuan Li, Chaio-Yun Tseng, Yueching Wong and Jing-Hsien Chen
Nutrients 2020, 12(11), 3535; https://0-doi-org.brum.beds.ac.uk/10.3390/nu12113535 - 18 Nov 2020
Cited by 13 | Viewed by 4746
Abstract
Melanogenesis has many important physiological functions. However, abnormal melanin production causes various pigmentation disorders. Melanin synthesis is stimulated by α-melanocyte stimulating hormone (α-MSH) and ultraviolet (UV) irradiation. Lotus seedpod extract (LSE) has been reported as possessing antioxidative, anti-aging, and anticancer activities. The present [...] Read more.
Melanogenesis has many important physiological functions. However, abnormal melanin production causes various pigmentation disorders. Melanin synthesis is stimulated by α-melanocyte stimulating hormone (α-MSH) and ultraviolet (UV) irradiation. Lotus seedpod extract (LSE) has been reported as possessing antioxidative, anti-aging, and anticancer activities. The present study examined the effect of LSE on melanogenesis and the involved signaling pathways in vitro and in vivo. Results showed that non-cytotoxic doses of LSE and its main component epigallocatechin (EGC) reduced both tyrosinase activity and melanin production in the α-MSH-induced melanoma cells. Western blotting data revealed that LSE and EGC inhibited expressions of tyrosinase and tyrosinase-related protein 1 (TRP-1). Phosphorylation of p38 and protein kinase A (PKA) stimulated by α-MSH was efficiently blocked by LSE treatment. Furthermore, LSE suppressed the nuclear level of cAMP-response element binding protein (CREB) and disturbed the activation of melanocyte inducing transcription factor (MITF) in the α-MSH-stimulated B16F0 cells. The in vivo study revealed that LSE inhibited melanin production in the ear skin of C57BL/6 mice after exposure to UVB. These findings suggested that the anti-melanogenesis of LSE involved both PKA and p38 signaling pathways. LSE is a potent novo natural depigmenting agent for cosmetics or pharmaceutical applications. Full article
(This article belongs to the Special Issue Natural and Synthetic Bioactives for Skin Health, Disease and Management)
►▼ Show Figures

Graphical abstract

13 pages, 1578 KiB  
Article
Cornus officinalis Ethanolic Extract with Potential Anti-Allergic, Anti-Inflammatory, and Antioxidant Activities
by Yixian Quah, Seung-Jin Lee, Eon-Bee Lee, Biruk Tesfaye Birhanu, Md. Sekendar Ali, Muhammad Aleem Abbas, Naila Boby, Zi-Eum Im and Seung-Chun Park
Nutrients 2020, 12(11), 3317; https://0-doi-org.brum.beds.ac.uk/10.3390/nu12113317 - 29 Oct 2020
Cited by 42 | Viewed by 5027
Abstract
Atopic dermatitis (AD) is an allergic and chronic inflammatory skin disease. The present study investigates the anti-allergic, antioxidant, and anti-inflammatory activities of the ethanolic extract of Cornus officinalis (COFE) for possible applications in the treatment of AD. COFE inhibits the release of β-hexosaminidase [...] Read more.
Atopic dermatitis (AD) is an allergic and chronic inflammatory skin disease. The present study investigates the anti-allergic, antioxidant, and anti-inflammatory activities of the ethanolic extract of Cornus officinalis (COFE) for possible applications in the treatment of AD. COFE inhibits the release of β-hexosaminidase from RBL-2H3 cells sensitized with the dinitrophenyl-immunoglobulin E (IgE-DNP) antibody after stimulation with dinitrophenyl-human serum albumin (DNP-HSA) in a concentration-dependent manner (IC50 = 0.178 mg/mL). Antioxidant activity determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, ferric reducing antioxidant power assay, and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) scavenging activity, result in EC50 values of 1.82, 10.76, and 0.6 mg/mL, respectively. Moreover, the extract significantly inhibits lipopolysaccharide (LPS)-induced nitric oxide (NO) production and the mRNA expression of iNOS and pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) through attenuation of NF-κB activation in RAW 264.7 cells. COFE significantly inhibits TNF-α-induced apoptosis in HaCaT cells without cytotoxic effects (p < 0.05). Furthermore, 2-furancarboxaldehyde and loganin are identified by gas chromatography/mass spectrometry (GC-MS) and liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis, respectively, as the major compounds. Molecular docking analysis shows that loganin, cornuside, and naringenin 7-O-β-D-glucoside could potentially disrupt the binding of IgE to human high-affinity IgE receptors (FceRI). Our results suggest that COFE might possess potential inhibitory effects on allergic responses, oxidative stress, and inflammatory responses. Full article
(This article belongs to the Special Issue Natural and Synthetic Bioactives for Skin Health, Disease and Management)
►▼ Show Figures

Graphical abstract

13 pages, 2397 KiB  
Article
Effect of Konjac Glucomannan (KGM) on the Reconstitution of the Dermal Environment against UVB-Induced Condition
by Kyung Ho Choi, Sung Tae Kim, Bum Ho Bin and Phil June Park
Nutrients 2020, 12(9), 2779; https://0-doi-org.brum.beds.ac.uk/10.3390/nu12092779 - 11 Sep 2020
Cited by 6 | Viewed by 4171
Abstract
Skin layers serve as a barrier against unexpected critical changes in the body due to environmental factors. Excessive ultraviolet (UV) B exposure increases the levels of age-related factors, leading to senescent cells and damaged skin tissues. Widely used as a dietary supplement, konjac [...] Read more.
Skin layers serve as a barrier against unexpected critical changes in the body due to environmental factors. Excessive ultraviolet (UV) B exposure increases the levels of age-related factors, leading to senescent cells and damaged skin tissues. Widely used as a dietary supplement, konjac (Amorphophallus konjac) glucomannan (KGM) has shown skin regeneration potential in patch or sheet form with anti-inflammatory or immunosuppressive effects. However, the ability of KGM to reconstitute senescent/damaged skin following UV radiation has not been explored. Here, we demonstrate that KGM alleviates skin damage by increasing the proportion of young cell populations in UVB-exposed senescent human epidermal primary melanocytes. Young cell numbers increased depending on KGM dosage, but the senescent cells were not removed. Real-time quantitative polymerase chain reaction (RT-qPCR) and Western blot analysis showed that mRNA and protein levels of age- and pigmentation-related factors decreased in a manner dependent on the rate at which new cells were generated. Moreover, an analysis of mRNA and protein levels indicated that KGM facilitated youth by increasing cell proliferation in UVB-damaged human fibroblasts. Thus, KGM is a highly effective natural agent for maintaining skin homeostasis by promoting the reconstitution of the dermal environment against UVB-induced acute senescence or skin damage. Full article
(This article belongs to the Special Issue Natural and Synthetic Bioactives for Skin Health, Disease and Management)
►▼ Show Figures

Figure 1

16 pages, 2383 KiB  
Article
Thymocid®, a Standardized Black Cumin (Nigella sativa) Seed Extract, Modulates Collagen Cross-Linking, Collagenase and Elastase Activities, and Melanogenesis in Murine B16F10 Melanoma Cells
by Huifang Li, Nicholas A. DaSilva, Weixi Liu, Jialin Xu, George W. Dombi, Joel A. Dain, Dongli Li, Jean Christopher Chamcheu, Navindra P. Seeram and Hang Ma
Nutrients 2020, 12(7), 2146; https://0-doi-org.brum.beds.ac.uk/10.3390/nu12072146 - 19 Jul 2020
Cited by 22 | Viewed by 6404
Abstract
Black cumin (Nigella sativa) seed extract has been shown to improve dermatological conditions, yet its beneficial effects for skin are not fully elucidated. Herein, Thymocid®, a chemically standardized black cumin seed extract, was investigated for its cosmeceutical potential including [...] Read more.
Black cumin (Nigella sativa) seed extract has been shown to improve dermatological conditions, yet its beneficial effects for skin are not fully elucidated. Herein, Thymocid®, a chemically standardized black cumin seed extract, was investigated for its cosmeceutical potential including anti-aging properties associated with modulation of glycation, collagen cross-linking, and collagenase and elastase activities, as well as antimelanogenic effect in murine melanoma B16F10 cells. Thymocid® (50, 100, and 300 µg/mL) inhibited the formation of advanced glycation end-products (by 16.7–70.7%), collagen cross-linking (by 45.1–93.3%), collagenase activity (by 10.4–92.4%), and elastases activities (type I and III by 25.3–75.4% and 36.0–91.1%, respectively). In addition, Thymocid® (2.5–20 µg/mL) decreased melanin content in B16F10 cells by 42.5–61.6% and reduced cellular tyrosinase activity by 20.9% (at 20 µg/mL). Furthermore, Thymocid® (20 µg/mL for 72 h) markedly suppressed the mRNA expression levels of melanogenesis-related genes including microphthalmia-associated transcription factor (MITF), tyrosinase-related protein 1 (TYRP1), and TYRP2 to 78.9%, 0.3%, and 0.2%, respectively. Thymocid® (10 µg/mL) also suppressed the protein expression levels of MITF (by 15.2%) and TYRP1 (by 97.7%). Findings from this study support the anti-aging and antimelanogenic potential of Thymocid® as a bioactive cosmeceutical ingredient for skin care products. Full article
(This article belongs to the Special Issue Natural and Synthetic Bioactives for Skin Health, Disease and Management)
►▼ Show Figures

Graphical abstract

11 pages, 1750 KiB  
Article
Lactobacillus helveticus-Fermented Milk Whey Suppresses Melanin Production by Inhibiting Tyrosinase through Decreasing MITF Expression
by Nobutomo Ikarashi, Natsuko Fukuda, Makiba Ochiai, Mami Sasaki, Risako Kon, Hiroyasu Sakai, Misaki Hatanaka and Junzo Kamei
Nutrients 2020, 12(7), 2082; https://0-doi-org.brum.beds.ac.uk/10.3390/nu12072082 - 14 Jul 2020
Cited by 10 | Viewed by 3552
Abstract
Whey obtained from milk fermented by the Lactobacillus helveticus CM4 strain (LHMW) has been shown to improve skin barrier function and increase skin-moisturizing factors. In this study, we investigated the effects of LHMW on melanin production to explore the additional impacts of LHMW [...] Read more.
Whey obtained from milk fermented by the Lactobacillus helveticus CM4 strain (LHMW) has been shown to improve skin barrier function and increase skin-moisturizing factors. In this study, we investigated the effects of LHMW on melanin production to explore the additional impacts of LHMW on the skin. We treated mouse B16 melanoma cells with α-melanocyte-stimulating hormone (α-MSH) alone or simultaneously with LHMW and measured the amount of melanin. The amount of melanin in B16 cells treated with α-MSH significantly increased by 2-fold compared with that in control cells, and tyrosinase activity was also elevated. Moreover, treatment with LHMW significantly suppressed the increase in melanin content and elevation of tyrosinase activity due to α-MSH. LHMW also suppressed the α-MSH-induced increased expression of tyrosinase, tyrosinase-related protein 1 (TRP1), and dopachrome tautomerase (DCT) at the protein and mRNA levels. Furthermore, the mRNA and protein microphthalmia-associated transcription factor (MITF) expression levels were significantly increased with treatment with α-MSH alone, which were also suppressed by LHMW addition. LHMW suppression of melanin production is suggested to involve inhibition of the expression of the tyrosinase gene family by lowering the MITF expression level. LHMW may have promise as a material for cosmetics with expected clinical application in humans. Full article
(This article belongs to the Special Issue Natural and Synthetic Bioactives for Skin Health, Disease and Management)
►▼ Show Figures

Figure 1

15 pages, 2313 KiB  
Article
A Glycosaminoglycan-Rich Fraction from Sea Cucumber Isostichopus badionotus Has Potent Anti-Inflammatory Properties In Vitro and In Vivo
by Leticia Olivera-Castillo, George Grant, Nuvia Kantún-Moreno, Hirian A. Barrera-Pérez, Jorge Montero, Miguel A. Olvera-Novoa, Leydi M. Carrillo-Cocom, Juan J. Acevedo, Cesar Puerto-Castillo, Victor May Solís, Juan A. Pérez-Vega, Judit Gil-Zamorano, Enrique Hernández-Garibay, María A. Fernández-Herrera, Mayra Pérez-Tapia, Oscar Medina-Contreras, Jairo R. Villanueva-Toledo, Rossanna Rodriguez-Canul and Alberto Dávalos
Nutrients 2020, 12(6), 1698; https://0-doi-org.brum.beds.ac.uk/10.3390/nu12061698 - 06 Jun 2020
Cited by 14 | Viewed by 4384
Abstract
Sea cucumber body wall contains several naturally occurring bioactive components that possess health-promoting properties. Isostichopus badionotus from Yucatan, Mexico is heavily fished, but little is known about its bioactive constituents. We previously established that I. badionotus meal had potent anti-inflammatory properties in vivo. [...] Read more.
Sea cucumber body wall contains several naturally occurring bioactive components that possess health-promoting properties. Isostichopus badionotus from Yucatan, Mexico is heavily fished, but little is known about its bioactive constituents. We previously established that I. badionotus meal had potent anti-inflammatory properties in vivo. We have now screened some of its constituents for anti-inflammatory activity in vitro. Glycosaminoglycan and soluble protein preparations reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammatory responses in HaCaT cells while an ethanol extract had a limited effect. The primary glycosaminoglycan (fucosylated chondroitin sulfate; FCS) was purified and tested for anti-inflammatory activity in vivo. FCS modulated the expression of critical genes, including NF-ĸB, TNFα, iNOS, and COX-2, and attenuated inflammation and tissue damage caused by TPA in a mouse ear inflammation model. It also mitigated colonic colitis caused in mice by dextran sodium sulfate. FCS from I. badionotus of the Yucatan Peninsula thus had strong anti-inflammatory properties in vivo. Full article
(This article belongs to the Special Issue Natural and Synthetic Bioactives for Skin Health, Disease and Management)
►▼ Show Figures

Graphical abstract

21 pages, 6478 KiB  
Article
Treatment with Modified Extracts of the Microalga Planktochlorella nurekis Attenuates the Development of Stress-Induced Senescence in Human Skin Cells
by Jagoda Adamczyk-Grochala, Maciej Wnuk, Magdalena Duda, Janusz Zuczek and Anna Lewinska
Nutrients 2020, 12(4), 1005; https://0-doi-org.brum.beds.ac.uk/10.3390/nu12041005 - 06 Apr 2020
Cited by 7 | Viewed by 2926
Abstract
More recently, we have proposed a safe non-vector approach to modifying the biochemical profiles of the microalga Planktochlorella nurekis and obtained twelve clones with improved content of lipids and selected pigments and B vitamins and antioxidant activity compared to unaffected cells. In the [...] Read more.
More recently, we have proposed a safe non-vector approach to modifying the biochemical profiles of the microalga Planktochlorella nurekis and obtained twelve clones with improved content of lipids and selected pigments and B vitamins and antioxidant activity compared to unaffected cells. In the present study, the biological activity of water and ethanolic extracts of modified clones is investigated in the context of their applications in the cosmetic industry and regenerative medicine. Extract-mediated effects on cell cycle progression, proliferation, migration, mitogenic response, apoptosis induction, and oxidative and nitrosative stress promotion were analyzed in normal human fibroblasts and keratinocytes in vitro. Microalgal extracts did not promote cell proliferation and were relatively non-cytotoxic when short-term treatment was considered. Long-term stimulation with selected microalgal extracts attenuated the development of oxidative stress-induced senescence in skin cells that, at least in part, was correlated with nitric oxide signaling and increased niacin and biotin levels compared to an unmodified microalgal clone. We postulate that selected microalgal extracts of Planktochlorella nurekis can be considered to be used in skin anti-aging therapy. Full article
(This article belongs to the Special Issue Natural and Synthetic Bioactives for Skin Health, Disease and Management)
►▼ Show Figures

Figure 1

10 pages, 1240 KiB  
Article
Expression Profiles of Genes Encoding Cornified Envelope Proteins in Atopic Dermatitis and Cutaneous T-Cell Lymphomas
by Magdalena Trzeciak, Berenika Olszewska, Monika Sakowicz-Burkiewicz, Małgorzata Sokołowska-Wojdyło, Jerzy Jankau, Roman Janusz Nowicki and Tadeusz Pawełczyk
Nutrients 2020, 12(3), 862; https://0-doi-org.brum.beds.ac.uk/10.3390/nu12030862 - 24 Mar 2020
Cited by 17 | Viewed by 3781
Abstract
The skin barrier defect in cutaneous T-cell lymphomas (CTCL) was recently confirmed to be similar to the one observed in atopic dermatitis (AD). We have examined the expression level of cornified envelope (CE) proteins in CTCL, AD and healthy skin, to search for [...] Read more.
The skin barrier defect in cutaneous T-cell lymphomas (CTCL) was recently confirmed to be similar to the one observed in atopic dermatitis (AD). We have examined the expression level of cornified envelope (CE) proteins in CTCL, AD and healthy skin, to search for the differences and their relation to the courses of both diseases. The levels of FLG, FLG2, RPTN, HRNR, SPRR1A, SPRR1B, SPRR3 and LELP-1 mRNA were determined by qRT-PCR, while protein levels were examined using the ELISA method in skin samples. We have found that mRNA levels of FLG, FLG2, LOR, CRNN and SPRR3v1 were decreased (p ≤ 0.04), whereas mRNA levels of RPTN, HRNR and SPRR1Av1 were increased in lesional and nonlesional AD skin compared to the healthy control group (p ≤ 0.04). The levels of FLG, FLG2, CRNN, SPRR3v1 mRNA increased (p ≤ 0.02) and RPTN, HRNR and SPRR1Av1 mRNA decreased (p ≤ 0.005) in CTCL skin compared to the lesional AD skin. There was a strong correlation between the stage of CTCL and increased SPRR1Av1 gene expression at both mRNA (R = 0.89; p ≤ 0.05) and protein levels (R = 0.94; p ≤ 0.05). FLG, FLG2, RPTN, HRNR and SPRR1A seem to play a key role in skin barrier dysfunction in CTCL and could be considered a biomarker for differential diagnosis of AD and CTCL. SPRR1Av1 transcript levels seem to be a possible marker of CTCL stage, however, further studies on a larger study group are needed to confirm our findings. Full article
(This article belongs to the Special Issue Natural and Synthetic Bioactives for Skin Health, Disease and Management)
►▼ Show Figures

Figure 1

15 pages, 3773 KiB  
Article
Anti-Melanogenic Effect of Ethanolic Extract of Sorghum bicolor on IBMX–Induced Melanogenesis in B16/F10 Melanoma Cells
by Hye Ju Han, Seon Kyeong Park, Jin Yong Kang, Jong Min Kim, Seul Ki Yoo and Ho Jin Heo
Nutrients 2020, 12(3), 832; https://0-doi-org.brum.beds.ac.uk/10.3390/nu12030832 - 20 Mar 2020
Cited by 26 | Viewed by 4671
Abstract
To evaluate possibility as a skin whitening agent of Sorghum bicolor (S. bicolor), its antioxidant activity and anti-melanogenic effect on 3-isobutyl-1-methylxanthine (IBMX)-induced melanogenesis in B16/F10 melanoma cells were investigated. The result of total phenolic contents (TPC) indicated that 60% ethanol extract [...] Read more.
To evaluate possibility as a skin whitening agent of Sorghum bicolor (S. bicolor), its antioxidant activity and anti-melanogenic effect on 3-isobutyl-1-methylxanthine (IBMX)-induced melanogenesis in B16/F10 melanoma cells were investigated. The result of total phenolic contents (TPC) indicated that 60% ethanol extract of S. bicolor (ESB) has the highest contents than other ethanol extracts. Antioxidant activity was evaluated using the 2,2’-azino-bis-(3-ethylbenzothiazolin-6-sulfonic acid) diammonium salt (ABTS)/1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging activities and malondialdehyde (MDA) inhibitory effect. These results showed ESB has significant antioxidant activities. Inhibitory effect against tyrosinase was also assessed using L-tyrosine (IC50 value = 89.25 μg/mL) and 3,4-dihydroxy-L-phenylalanine (L-DOPA) as substrates. In addition, ESB treatment effectively inhibited melanin production in IBMX-induced B16/F10 melanoma cells. To confirm the mechanism on anti-melanogenic effect of ESB, we examined melanogenesis-related proteins. ESB downregulated melanogenesis by decreasing expression of microphthalmia-associated transcription factor (MITF), tyrosinase and tyrosinase-related protein (TRP)-1. Finally, 9-hydroxyoctadecadienoic acid (9-HODE), 1,3-O-dicaffeoylglycerol and tricin as the main compounds of ESB were analyzed using the ultra-performance liquid chromatography-ion mobility separation-quadrupole time of flight/tandem mass spectrometry (UPLC-IMS-QTOF/MS2). These findings suggest that ESB may have physiological potential to be used skin whitening material. Full article
(This article belongs to the Special Issue Natural and Synthetic Bioactives for Skin Health, Disease and Management)
►▼ Show Figures

Graphical abstract

7 pages, 636 KiB  
Communication
Enhanced Triacylglycerol Content and Gene Expression for Triacylglycerol Metabolism, Acyl-Ceramide Synthesis, and Corneocyte Lipid Formation in the Epidermis of Borage Oil Fed Guinea Pigs
by Ju-Young Lee, Kwang-Hyeon Liu, Yunhi Cho and Kun-Pyo Kim
Nutrients 2019, 11(11), 2818; https://0-doi-org.brum.beds.ac.uk/10.3390/nu11112818 - 18 Nov 2019
Cited by 6 | Viewed by 3407
Abstract
Triacylglycerol (TAG) metabolism is related to the acyl-ceramide (Cer) synthesis and corneocyte lipid envelope (CLE) formation involved in maintaining the epidermal barrier. Prompted by the recovery of a disrupted epidermal barrier with dietary borage oil (BO: 40.9% linoleic acid (LNA) and 24.0% γ-linolenic [...] Read more.
Triacylglycerol (TAG) metabolism is related to the acyl-ceramide (Cer) synthesis and corneocyte lipid envelope (CLE) formation involved in maintaining the epidermal barrier. Prompted by the recovery of a disrupted epidermal barrier with dietary borage oil (BO: 40.9% linoleic acid (LNA) and 24.0% γ-linolenic acid (GLA)) in essential fatty acid (EFA) deficiency, lipidomic and transcriptome analyses and subsequent quantitative RT-PCR were performed to determine the effects of borage oil (BO) on TAG content and species, and the gene expression related to overall lipid metabolism. Dietary BO for 2 weeks in EFA-deficient guinea pigs increased the total TAG content, including the TAG species esterified LNA, GLA, and their C20 metabolized fatty acids. Moreover, the expression levels of genes in the monoacylglycerol and glycerol-3-phosphate pathways, two major pathways of TAG synthesis, increased, along with those of TAG lipase, acyl-Cer synthesis, and CLE formation. Dietary BO enhanced TAG content, the gene expression of TAG metabolism, acyl-Cer synthesis, and CLE formation. Full article
(This article belongs to the Special Issue Natural and Synthetic Bioactives for Skin Health, Disease and Management)
►▼ Show Figures

Figure 1

12 pages, 2510 KiB  
Article
Synergistic Cytoprotective Effects of Rutin and Ascorbic Acid on the Proteomic Profile of 3D-Cultured Keratinocytes Exposed to UVA or UVB Radiation
by Agnieszka Gęgotek, Iwona Jarocka-Karpowicz and Elżbieta Skrzydlewska
Nutrients 2019, 11(11), 2672; https://0-doi-org.brum.beds.ac.uk/10.3390/nu11112672 - 05 Nov 2019
Cited by 21 | Viewed by 3731
Abstract
The combination of ascorbic acid and rutin, often used in oral preparations, due to antioxidant and anti-inflammatory properties, can be used to protect skin cells against the effects of UV radiation from sunlight. Therefore, the aim of this study was to investigate the [...] Read more.
The combination of ascorbic acid and rutin, often used in oral preparations, due to antioxidant and anti-inflammatory properties, can be used to protect skin cells against the effects of UV radiation from sunlight. Therefore, the aim of this study was to investigate the synergistic effect of rutin and ascorbic acid on the proteomic profile of UVA and UVB irradiated keratinocytes cultured in a three-dimensional (3D) system. Results showed that the combination of rutin and ascorbic acid protects skin cells against UV-induced changes. In particular, alterations were observed in the expression of proteins involved in the antioxidant response, DNA repairing, inflammation, apoptosis, and protein biosynthesis. The combination of rutin and ascorbic acid also showed a stronger cytoprotective effect than when using either compound alone. Significant differences were visible between rutin and ascorbic acid single treatments in the case of protein carboxymethylation/carboxyethylation. Ascorbic acid prevented UV or rutin-induced protein modifications. Therefore, the synergistic effect of rutin and ascorbic acid creates a potentially effective protective system against skin damages caused by UVA and UVB radiation. Full article
(This article belongs to the Special Issue Natural and Synthetic Bioactives for Skin Health, Disease and Management)
►▼ Show Figures

Figure 1

Review

Jump to: Editorial, Research

26 pages, 6203 KiB  
Review
A Review on Antifungal Efficiency of Plant Extracts Entrenched Polysaccharide-Based Nanohydrogels
by Navkiranjeet Kaur, Aarti Bains, Ravinder Kaushik, Sanju B. Dhull, Fogarasi Melinda and Prince Chawla
Nutrients 2021, 13(6), 2055; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13062055 - 15 Jun 2021
Cited by 31 | Viewed by 9992
Abstract
Human skin acts as a physical barrier; however, sometimes the skin gets infected by fungi, which becomes more severe if the infection occurs on the third layer of the skin. Azole derivative-based antifungal creams, liquids, or sprays are available to treat fungal infections; [...] Read more.
Human skin acts as a physical barrier; however, sometimes the skin gets infected by fungi, which becomes more severe if the infection occurs on the third layer of the skin. Azole derivative-based antifungal creams, liquids, or sprays are available to treat fungal infections; however, these formulations show various side effects on the application site. Over the past few years, herbal extracts and various essential oils have shown effective antifungal activity. Additionally, autoxidation and epimerization are significant problems with the direct use of herbal extracts. Hence, to overcome these obstacles, polysaccharide-based nanohydrogels embedded with natural plant extracts and oils have become the primary choice of pharmaceutical scientists. These gels protect plant-based bioactive compounds and are effective delivery agents because they release multiple bioactive compounds in the targeted area. Nanohydrogels can be applied to infected areas, and due to their contagious nature and penetration power, they get directly absorbed through the skin, quickly reaching the skin’s third layer and effectively reducing the fungal infection. In this review, we explain various skin fungal infections, possible treatments, and the effective utilization of plant extract and oil-embedded polysaccharide-based nanohydrogels. Full article
(This article belongs to the Special Issue Natural and Synthetic Bioactives for Skin Health, Disease and Management)
►▼ Show Figures

Graphical abstract

31 pages, 3582 KiB  
Review
Bioactive Compounds for Skin Health: A Review
by Monika Michalak, Monika Pierzak, Beata Kręcisz and Edyta Suliga
Nutrients 2021, 13(1), 203; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13010203 - 12 Jan 2021
Cited by 100 | Viewed by 30470
Abstract
Human skin is continually changing. The condition of the skin largely depends on the individual’s overall state of health. A balanced diet plays an important role in the proper functioning of the human body, including the skin. The present study draws attention to [...] Read more.
Human skin is continually changing. The condition of the skin largely depends on the individual’s overall state of health. A balanced diet plays an important role in the proper functioning of the human body, including the skin. The present study draws attention to bioactive substances, i.e., vitamins, minerals, fatty acids, polyphenols, and carotenoids, with a particular focus on their effects on the condition of the skin. The aim of the study was to review the literature on the effects of bioactive substances on skin parameters such as elasticity, firmness, wrinkles, senile dryness, hydration and color, and to define their role in the process of skin ageing. Full article
(This article belongs to the Special Issue Natural and Synthetic Bioactives for Skin Health, Disease and Management)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-19
Back to TopTop