Special Issue "The Efficacy and Role of Dietary Polyphenols"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: 1 July 2021.

Special Issue Editor

Special Issue Information

Dear Colleagues,

In the last several years, the importance of balanced dietary patterns in human health has been widely recognized. Dietary guidelines around the world recommend the increased consumption of fruits and vegetables, as good sources of dietary fiber, essential nutrients, and phytochemicals, to improve health and reduce the  risk of several chronic diseases, including metabolic disorder, diabetes, obesity, cardiovascular diseases, and some types of cancer. In this context, numerous studies have demonstrated the wide biological properties exerted by dietary phytochemicals, highlighting their beneficial role both in the prevention and in the treatment of several pathological conditions.

This Special Issue will include manuscripts, in the form of original research or review articles, that cover all aspects of the complex relationship between dietary polyphenols and human health, ranging from their bioavailability and gut microbiota interaction to the molecular mechanisms through which these compounds exert their health benefits. Studies with multidisciplinary input, offering new mechanisms or insights, are particularly welcome.

Dr. Francesca Giampieri
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrition
  • human health
  • dietary intake
  • bioactive compounds
  • dietary phytochemicals
  • nutraceuticals
  • functional foods
  • medicinal products
  • natural antioxidants
  • nutrigenetics
  • nutrigenomics
  • bioavailability
  • pharmacodynamics and pharmacokinetics of polyphenols
  • gut microbiota
  • molecular mechanisms
  • safety and efficacy

Published Papers (1 paper)

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Research

Article
The Metabolomic-Gut-Clinical Axis of Mankai Plant-Derived Dietary Polyphenols
Nutrients 2021, 13(6), 1866; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13061866 - 30 May 2021
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Abstract
Background: Polyphenols are secondary metabolites produced by plants to defend themselves from environmental stressors. We explored the effect of Wolffia globosa ‘Mankai’, a novel cultivated strain of a polyphenol-rich aquatic plant, on the metabolomic-gut clinical axis in vitro, in-vivo and in a clinical [...] Read more.
Background: Polyphenols are secondary metabolites produced by plants to defend themselves from environmental stressors. We explored the effect of Wolffia globosa ‘Mankai’, a novel cultivated strain of a polyphenol-rich aquatic plant, on the metabolomic-gut clinical axis in vitro, in-vivo and in a clinical trial. Methods: We used mass-spectrometry-based metabolomics methods from three laboratories to detect Mankai phenolic metabolites and examined predicted functional pathways in a Mankai artificial-gut bioreactor. Plasma and urine polyphenols were assessed among the 294 DIRECT-PLUS 18-month trial participants, comparing the effect of a polyphenol-rich green-Mediterranean diet (+1240 mg/polyphenols/day, provided by Mankai, green tea and walnuts) to a walnuts-enriched (+440 mg/polyphenols/day) Mediterranean diet and a healthy controlled diet. Results: Approximately 200 different phenolic compounds were specifically detected in the Mankai plant. The Mankai-supplemented bioreactor artificial gut displayed a significantly higher relative-abundance of 16S-rRNA bacterial gene sequences encoding for enzymes involved in phenolic compound degradation. In humans, several Mankai-related plasma and urine polyphenols were differentially elevated in the green Mediterranean group compared with the other groups (p < 0.05) after six and 18 months of intervention (e.g., urine hydroxy-phenyl-acetic-acid and urolithin-A; plasma Naringenin and 2,5-diOH-benzoic-acid). Specific polyphenols, such as urolithin-A and 4-ethylphenol, were directly involved with clinical weight-related changes. Conclusions: The Mankai new plant is rich in various unique potent polyphenols, potentially affecting the metabolomic-gut-clinical axis. Full article
(This article belongs to the Special Issue The Efficacy and Role of Dietary Polyphenols)
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